Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls

Constanze Kortuem,1,&ast; Johannes Dietter,2,&ast; Yagmur Bozkurt,2 Friederike Charlotte Kortuem,1 Annegret Abaza,1 Siegfried Wahl,2,3 Iliya V Ivanov,2,3 Marius Ueffing,2 Bogomil Voykov1 1Department of Ophthalmology, University Eye Hospital, Eberhard Karls University Tuebingen, Tuebingen, Ge...

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Autores principales:	Kortuem C, Dietter J, Bozkurt Y, Kortuem FC, Abaza A, Wahl S, Ivanov IV, Ueffing M, Voykov B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	avr crae crve tortuosity of vessels fractal dimensions Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7f60ac5b3909426a8e5d722202f8cb41
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spelling	oai:doaj.org-article:7f60ac5b3909426a8e5d722202f8cb412021-12-02T16:52:25ZVessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls1177-5483https://doaj.org/article/7f60ac5b3909426a8e5d722202f8cb412021-10-01T00:00:00Zhttps://www.dovepress.com/vessel-evaluation-in-patients-with-primary-open-angle-glaucoma-normal--peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Constanze Kortuem,1,&ast; Johannes Dietter,2,&ast; Yagmur Bozkurt,2 Friederike Charlotte Kortuem,1 Annegret Abaza,1 Siegfried Wahl,2,3 Iliya V Ivanov,2,3 Marius Ueffing,2 Bogomil Voykov1 1Department of Ophthalmology, University Eye Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany; 2Department of Ophthalmology, Institute for Ophthalmic Research University of Tuebingen, Tuebingen, Germany; 3Carl Zeiss Vision International GmbH, Aalen, Germany&ast;These authors contributed equally to this workCorrespondence: Constanze KortuemDepartment of Ophthalmology, Eberhard Karls University Tuebingen, Elfriede-Aulhorn-Str. 7, Tuebingen, 72076, GermanyTel +49 7071 29-88687Fax +49 7071 293749Email Constanze.kortuem@med.uni-tuebingen.dePurpose: To compare changes in central retinal arterial equivalent (CRAE), central retinal vein equivalent (CRVE), arteriovenous ratio (AVR), tortuosity and fractal dimension in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and in a control group (CG) on fundus photographs. Further, to provide further evidence of vascular change in glaucoma patients using a novel method of tortuosity.Patients and Methods: The primary endpoint was the change in CRAE, CRVE, AVR, fractal dimension and tortuosity of the retinal vasculature from baseline, retrospectively analyzed from 2011 to 2017 at the University Eye Hospital Tuebingen. Fundus photos of POAG (N = 49), NTG (N = 38) and CG (N = 18) were computer evaluated and analyzed in the quantities mentioned above.Results: CRAE in NTG and POAG and CRVE in NTG significantly decreased (P = 0.02, P = 0.01; P = 0.03) whereas CRVE in POAG increased insignificantly (P = 0.72). In NTG, AVR decreased significantly (P = 0.05), but to a lesser extent than in POAG (P < 0.001). In CG, CRAE decreased insignificantly (P = 0.10), CRVE decreased significantly (P = 0.03) and AVR increased insignificantly (P = 0.77). In POAG tortuosity calculated using standard methods as well as our novel method, increased significantly (P = 0.015– 0.04), whereas it did not occur in NTG (P = 0.18– 0.57) and CG (P = 0.11– 0.21). Fractal dimensions in POAG decreased significantly (P = 0.001– 0.002), whereas in NTG and CG changes were insignificant (P = 0.33– 0.92).Conclusion: Based on a retrospective analysis of fundus photographs, specific retinal vasculature features of the retinal vasculature display significant alterations associated with NTG and POAG. The assessment of tortuosity using our novel method was consistent with previously established methods for analyzing tortuosity.Keywords: AVR, CRAE, CRVE, tortuosity of vessels, fractal dimensionsKortuem CDietter JBozkurt YKortuem FCAbaza AWahl SIvanov IVUeffing MVoykov BDove Medical Pressarticleavrcraecrvetortuosity of vesselsfractal dimensionsOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4269-4280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	avr crae crve tortuosity of vessels fractal dimensions Ophthalmology RE1-994
spellingShingle	avr crae crve tortuosity of vessels fractal dimensions Ophthalmology RE1-994 Kortuem C Dietter J Bozkurt Y Kortuem FC Abaza A Wahl S Ivanov IV Ueffing M Voykov B Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls
description	Constanze Kortuem,1,&ast; Johannes Dietter,2,&ast; Yagmur Bozkurt,2 Friederike Charlotte Kortuem,1 Annegret Abaza,1 Siegfried Wahl,2,3 Iliya V Ivanov,2,3 Marius Ueffing,2 Bogomil Voykov1 1Department of Ophthalmology, University Eye Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany; 2Department of Ophthalmology, Institute for Ophthalmic Research University of Tuebingen, Tuebingen, Germany; 3Carl Zeiss Vision International GmbH, Aalen, Germany&ast;These authors contributed equally to this workCorrespondence: Constanze KortuemDepartment of Ophthalmology, Eberhard Karls University Tuebingen, Elfriede-Aulhorn-Str. 7, Tuebingen, 72076, GermanyTel +49 7071 29-88687Fax +49 7071 293749Email Constanze.kortuem@med.uni-tuebingen.dePurpose: To compare changes in central retinal arterial equivalent (CRAE), central retinal vein equivalent (CRVE), arteriovenous ratio (AVR), tortuosity and fractal dimension in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and in a control group (CG) on fundus photographs. Further, to provide further evidence of vascular change in glaucoma patients using a novel method of tortuosity.Patients and Methods: The primary endpoint was the change in CRAE, CRVE, AVR, fractal dimension and tortuosity of the retinal vasculature from baseline, retrospectively analyzed from 2011 to 2017 at the University Eye Hospital Tuebingen. Fundus photos of POAG (N = 49), NTG (N = 38) and CG (N = 18) were computer evaluated and analyzed in the quantities mentioned above.Results: CRAE in NTG and POAG and CRVE in NTG significantly decreased (P = 0.02, P = 0.01; P = 0.03) whereas CRVE in POAG increased insignificantly (P = 0.72). In NTG, AVR decreased significantly (P = 0.05), but to a lesser extent than in POAG (P < 0.001). In CG, CRAE decreased insignificantly (P = 0.10), CRVE decreased significantly (P = 0.03) and AVR increased insignificantly (P = 0.77). In POAG tortuosity calculated using standard methods as well as our novel method, increased significantly (P = 0.015– 0.04), whereas it did not occur in NTG (P = 0.18– 0.57) and CG (P = 0.11– 0.21). Fractal dimensions in POAG decreased significantly (P = 0.001– 0.002), whereas in NTG and CG changes were insignificant (P = 0.33– 0.92).Conclusion: Based on a retrospective analysis of fundus photographs, specific retinal vasculature features of the retinal vasculature display significant alterations associated with NTG and POAG. The assessment of tortuosity using our novel method was consistent with previously established methods for analyzing tortuosity.Keywords: AVR, CRAE, CRVE, tortuosity of vessels, fractal dimensions
format	article
author	Kortuem C Dietter J Bozkurt Y Kortuem FC Abaza A Wahl S Ivanov IV Ueffing M Voykov B
author_facet	Kortuem C Dietter J Bozkurt Y Kortuem FC Abaza A Wahl S Ivanov IV Ueffing M Voykov B
author_sort	Kortuem C
title	Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls
title_short	Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls
title_full	Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls
title_fullStr	Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls
title_full_unstemmed	Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls
title_sort	vessel evaluation in patients with primary open-angle glaucoma, normal tension glaucoma and healthy controls
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7f60ac5b3909426a8e5d722202f8cb41
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Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls

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