Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, le...

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Autores principales:	Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a
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spelling	oai:doaj.org-article:7f62f67aa840473d94edc1b8db9c890a2021-12-02T17:06:05ZPiezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance10.1038/s41467-017-00429-32041-1723https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00429-3https://doaj.org/toc/2041-1723The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.Baptiste RodeJian ShiNaima EndeshMark J. DrinkhillPeter J. WebsterSabine J. LotteauMarc A. BaileyNadira Y. YuldashevaMelanie J. LudlowRichard M. CubbonJing LiT. Simon FutersLara MorleyHannah J. GauntKatarzyna MarszalekHema ViswambharanKevin CuthbertsonPaul D. BaxterRichard FosterPiruthivi SukumarAndrew WeightmanSarah C. CalaghanStephen B. WheatcroftMark T. KearneyDavid J. BeechNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baptiste Rode Jian Shi Naima Endesh Mark J. Drinkhill Peter J. Webster Sabine J. Lotteau Marc A. Bailey Nadira Y. Yuldasheva Melanie J. Ludlow Richard M. Cubbon Jing Li T. Simon Futers Lara Morley Hannah J. Gaunt Katarzyna Marszalek Hema Viswambharan Kevin Cuthbertson Paul D. Baxter Richard Foster Piruthivi Sukumar Andrew Weightman Sarah C. Calaghan Stephen B. Wheatcroft Mark T. Kearney David J. Beech Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
description	The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.
format	article
author	Baptiste Rode Jian Shi Naima Endesh Mark J. Drinkhill Peter J. Webster Sabine J. Lotteau Marc A. Bailey Nadira Y. Yuldasheva Melanie J. Ludlow Richard M. Cubbon Jing Li T. Simon Futers Lara Morley Hannah J. Gaunt Katarzyna Marszalek Hema Viswambharan Kevin Cuthbertson Paul D. Baxter Richard Foster Piruthivi Sukumar Andrew Weightman Sarah C. Calaghan Stephen B. Wheatcroft Mark T. Kearney David J. Beech
author_facet	Baptiste Rode Jian Shi Naima Endesh Mark J. Drinkhill Peter J. Webster Sabine J. Lotteau Marc A. Bailey Nadira Y. Yuldasheva Melanie J. Ludlow Richard M. Cubbon Jing Li T. Simon Futers Lara Morley Hannah J. Gaunt Katarzyna Marszalek Hema Viswambharan Kevin Cuthbertson Paul D. Baxter Richard Foster Piruthivi Sukumar Andrew Weightman Sarah C. Calaghan Stephen B. Wheatcroft Mark T. Kearney David J. Beech
author_sort	Baptiste Rode
title	Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
title_short	Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
title_full	Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
title_fullStr	Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
title_full_unstemmed	Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
title_sort	piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a
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Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

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