Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells

Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.

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Autores principales:	Ana Filipa Gonçalves, Mojca Adlesic, Simone Brandt, Tomas Hejhal, Sabine Harlander, Lukas Sommer, Olga Shakhova, Peter J. Wild, Ian J. Frew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f63d8e6ed024233ba49cb91bfbd8004
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spelling	oai:doaj.org-article:7f63d8e6ed024233ba49cb91bfbd80042021-12-02T14:40:36ZEvidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells10.1038/s41467-017-01514-32041-1723https://doaj.org/article/7f63d8e6ed024233ba49cb91bfbd80042017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01514-3https://doaj.org/toc/2041-1723Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.Ana Filipa GonçalvesMojca AdlesicSimone BrandtTomas HejhalSabine HarlanderLukas SommerOlga ShakhovaPeter J. WildIan J. FrewNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ana Filipa Gonçalves Mojca Adlesic Simone Brandt Tomas Hejhal Sabine Harlander Lukas Sommer Olga Shakhova Peter J. Wild Ian J. Frew Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
description	Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.
format	article
author	Ana Filipa Gonçalves Mojca Adlesic Simone Brandt Tomas Hejhal Sabine Harlander Lukas Sommer Olga Shakhova Peter J. Wild Ian J. Frew
author_facet	Ana Filipa Gonçalves Mojca Adlesic Simone Brandt Tomas Hejhal Sabine Harlander Lukas Sommer Olga Shakhova Peter J. Wild Ian J. Frew
author_sort	Ana Filipa Gonçalves
title	Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
title_short	Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
title_full	Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
title_fullStr	Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
title_full_unstemmed	Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
title_sort	evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f63d8e6ed024233ba49cb91bfbd8004
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Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells

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