ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples

The lack of interest in the determination of toxic elements in liquids for electronic cigarettes (e-liquids) has so far been reflected in the scarce number of accurate and validated analytical methods devoted to this aim. Since the strong matrix effects observed for e-liquids constitute an exciting...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrea Mara, Ilaria Langasco, Sara Deidda, Marco Caredda, Paola Meloni, Mario Deroma, Maria I. Pilo, Nadia Spano, Gavino Sanna
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	e-cigarettes e-liquids toxic elements trace elements ICP-MS Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/7f6ca69f817546a68a6a13de43909948
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7f6ca69f817546a68a6a13de43909948
record_format	dspace
spelling	oai:doaj.org-article:7f6ca69f817546a68a6a13de439099482021-11-11T18:38:15ZICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples10.3390/molecules262166801420-3049https://doaj.org/article/7f6ca69f817546a68a6a13de439099482021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6680https://doaj.org/toc/1420-3049The lack of interest in the determination of toxic elements in liquids for electronic cigarettes (e-liquids) has so far been reflected in the scarce number of accurate and validated analytical methods devoted to this aim. Since the strong matrix effects observed for e-liquids constitute an exciting analytical challenge, the main goal of this study was to develop and validate an ICP-MS method aimed to quantify 23 elements in 37 e-liquids of different flavors. Great attention has been paid to the critical phases of sample pre-treatment, as well as to the optimization of the ICP-MS conditions for each element and of the quantification. All samples exhibited a very low amount of the elements under investigation. Indeed, the sum of their average concentration was of ca. 0.6 mg kg<sup>−1</sup>. Toxic elements were always below a few tens of a μg per kg<sup>−1</sup> and, very often, their amount was below the relevant quantification limits. Tobacco and tonic flavors showed the highest and the lowest concentration of elements, respectively. The most abundant elements came frequently from propylene glycol and vegetal glycerin, as confirmed by PCA. A proper choice of these substances could further decrease the elemental concentration in e-liquids, which are probably barely involved as potential sources of toxic elements inhaled by vapers.Andrea MaraIlaria LangascoSara DeiddaMarco CareddaPaola MeloniMario DeromaMaria I. PiloNadia SpanoGavino SannaMDPI AGarticlee-cigarettese-liquidstoxic elementstrace elementsICP-MSOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6680, p 6680 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	e-cigarettes e-liquids toxic elements trace elements ICP-MS Organic chemistry QD241-441
spellingShingle	e-cigarettes e-liquids toxic elements trace elements ICP-MS Organic chemistry QD241-441 Andrea Mara Ilaria Langasco Sara Deidda Marco Caredda Paola Meloni Mario Deroma Maria I. Pilo Nadia Spano Gavino Sanna ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples
description	The lack of interest in the determination of toxic elements in liquids for electronic cigarettes (e-liquids) has so far been reflected in the scarce number of accurate and validated analytical methods devoted to this aim. Since the strong matrix effects observed for e-liquids constitute an exciting analytical challenge, the main goal of this study was to develop and validate an ICP-MS method aimed to quantify 23 elements in 37 e-liquids of different flavors. Great attention has been paid to the critical phases of sample pre-treatment, as well as to the optimization of the ICP-MS conditions for each element and of the quantification. All samples exhibited a very low amount of the elements under investigation. Indeed, the sum of their average concentration was of ca. 0.6 mg kg<sup>−1</sup>. Toxic elements were always below a few tens of a μg per kg<sup>−1</sup> and, very often, their amount was below the relevant quantification limits. Tobacco and tonic flavors showed the highest and the lowest concentration of elements, respectively. The most abundant elements came frequently from propylene glycol and vegetal glycerin, as confirmed by PCA. A proper choice of these substances could further decrease the elemental concentration in e-liquids, which are probably barely involved as potential sources of toxic elements inhaled by vapers.
format	article
author	Andrea Mara Ilaria Langasco Sara Deidda Marco Caredda Paola Meloni Mario Deroma Maria I. Pilo Nadia Spano Gavino Sanna
author_facet	Andrea Mara Ilaria Langasco Sara Deidda Marco Caredda Paola Meloni Mario Deroma Maria I. Pilo Nadia Spano Gavino Sanna
author_sort	Andrea Mara
title	ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples
title_short	ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples
title_full	ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples
title_fullStr	ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples
title_full_unstemmed	ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples
title_sort	icp-ms determination of 23 elements of potential health concern in liquids of e-cigarettes. method development, validation, and application to 37 real samples
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f6ca69f817546a68a6a13de43909948
work_keys_str_mv	AT andreamara icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT ilarialangasco icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT saradeidda icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT marcocaredda icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT paolameloni icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT marioderoma icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT mariaipilo icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT nadiaspano icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples AT gavinosanna icpmsdeterminationof23elementsofpotentialhealthconcerninliquidsofecigarettesmethoddevelopmentvalidationandapplicationto37realsamples
_version_	1718431772053602304

ICP-MS Determination of 23 Elements of Potential Health Concern in Liquids of e-Cigarettes. Method Development, Validation, and Application to 37 Real Samples

Ejemplares similares