Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours
Tumours can escape CD8 T-cell immunity by down-regulating antigen presentation machinery components, such as TAP. Here the authors describe tumour antigenic peptides processed by TAP-independent and -dependent pathways and show in mouse models that these peptides can be exploited to induce antitumor...
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Nature Portfolio
2018
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oai:doaj.org-article:7f6d68fe1b834788afc4ae75e54774382021-12-02T15:34:28ZHuman preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours10.1038/s41467-018-07603-12041-1723https://doaj.org/article/7f6d68fe1b834788afc4ae75e54774382018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07603-1https://doaj.org/toc/2041-1723Tumours can escape CD8 T-cell immunity by down-regulating antigen presentation machinery components, such as TAP. Here the authors describe tumour antigenic peptides processed by TAP-independent and -dependent pathways and show in mouse models that these peptides can be exploited to induce antitumor T-cell activity when TAP expression is downregulated.Aurélie DurgeauYasemin VirkGwendoline GrosElodie VoilinStéphanie CorgnacFayçal DjenidiJérôme SalmonJulien AdamVincent de MontprévillePierre ValidireSoldano FerroneSalem ChouaibAlexander EggermontJean-Charles SoriaFrançois LemonnierEric TartourNathalie ChaputBenjamin BesseFathia Mami-ChouaibNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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Science Q Aurélie Durgeau Yasemin Virk Gwendoline Gros Elodie Voilin Stéphanie Corgnac Fayçal Djenidi Jérôme Salmon Julien Adam Vincent de Montpréville Pierre Validire Soldano Ferrone Salem Chouaib Alexander Eggermont Jean-Charles Soria François Lemonnier Eric Tartour Nathalie Chaput Benjamin Besse Fathia Mami-Chouaib Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours |
| description |
Tumours can escape CD8 T-cell immunity by down-regulating antigen presentation machinery components, such as TAP. Here the authors describe tumour antigenic peptides processed by TAP-independent and -dependent pathways and show in mouse models that these peptides can be exploited to induce antitumor T-cell activity when TAP expression is downregulated. |
| format |
article |
| author |
Aurélie Durgeau Yasemin Virk Gwendoline Gros Elodie Voilin Stéphanie Corgnac Fayçal Djenidi Jérôme Salmon Julien Adam Vincent de Montpréville Pierre Validire Soldano Ferrone Salem Chouaib Alexander Eggermont Jean-Charles Soria François Lemonnier Eric Tartour Nathalie Chaput Benjamin Besse Fathia Mami-Chouaib |
| author_facet |
Aurélie Durgeau Yasemin Virk Gwendoline Gros Elodie Voilin Stéphanie Corgnac Fayçal Djenidi Jérôme Salmon Julien Adam Vincent de Montpréville Pierre Validire Soldano Ferrone Salem Chouaib Alexander Eggermont Jean-Charles Soria François Lemonnier Eric Tartour Nathalie Chaput Benjamin Besse Fathia Mami-Chouaib |
| author_sort |
Aurélie Durgeau |
| title |
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours |
| title_short |
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours |
| title_full |
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours |
| title_fullStr |
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours |
| title_full_unstemmed |
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours |
| title_sort |
human preprocalcitonin self-antigen generates tap-dependent and -independent epitopes triggering optimised t-cell responses toward immune-escaped tumours |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/7f6d68fe1b834788afc4ae75e5477438 |
| work_keys_str_mv |
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