Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting

Abstract Introduction Oxytocin receptor (OXTR) gene polymorphism reportedly moderates effects of negative environments during childhood on mental function and behavior such as depressive symptoms and externalizing problems. This study examined OXTR gene polymorphism effects on personality traits in...

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Autores principales:	Keisuke Noto, Akihito Suzuki, Toshinori Shirata, Yoshihiko Matsumoto, Haruka Muraosa, Kaoru Goto, Koichi Otani
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	oxytocin parenting personality polymorphism receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/7f705adb9fc94391895011f1295c0138
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spelling	oai:doaj.org-article:7f705adb9fc94391895011f1295c01382021-11-25T06:06:36ZOxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting2162-327910.1002/brb3.2393https://doaj.org/article/7f705adb9fc94391895011f1295c01382021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2393https://doaj.org/toc/2162-3279Abstract Introduction Oxytocin receptor (OXTR) gene polymorphism reportedly moderates effects of negative environments during childhood on mental function and behavior such as depressive symptoms and externalizing problems. This study examined OXTR gene polymorphism effects on personality traits in healthy participants, considering interaction effects of polymorphism with affectionless control (AC) parenting which is one of the dysfunctional and pathogenic parenting styles. Methods For 496 Japanese volunteers, personality was evaluated using the Temperament and Character Inventory. The Parental Bonding Instrument, which has subscales of care and protection, was used to assess perceived parental rearing. AC parenting was defined as low care and high protection. A/G polymorphism of the OXTR gene (rs53576) was detected using TaqMan SNP Genotyping Assay. Results Two‐way analysis of covariance revealed significant interaction effects between the genotype and the number of AC parents on scores of harm avoidance, with no significant main effect of genotype on any personality. Post‐hoc analysis revealed that the harm avoidance scores were increased in a stepwise manner with respect to the increase of the number of AC parents in the A allele carriers. No similar association was observed in the A allele noncarriers. Conclusion The results of this study suggest that OXTR polymorphism influences characterization of harm avoidance by moderating susceptibility to AC parenting.Keisuke NotoAkihito SuzukiToshinori ShirataYoshihiko MatsumotoHaruka MuraosaKaoru GotoKoichi OtaniWileyarticleoxytocinparentingpersonalitypolymorphismreceptorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxytocin parenting personality polymorphism receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	oxytocin parenting personality polymorphism receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Keisuke Noto Akihito Suzuki Toshinori Shirata Yoshihiko Matsumoto Haruka Muraosa Kaoru Goto Koichi Otani Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
description	Abstract Introduction Oxytocin receptor (OXTR) gene polymorphism reportedly moderates effects of negative environments during childhood on mental function and behavior such as depressive symptoms and externalizing problems. This study examined OXTR gene polymorphism effects on personality traits in healthy participants, considering interaction effects of polymorphism with affectionless control (AC) parenting which is one of the dysfunctional and pathogenic parenting styles. Methods For 496 Japanese volunteers, personality was evaluated using the Temperament and Character Inventory. The Parental Bonding Instrument, which has subscales of care and protection, was used to assess perceived parental rearing. AC parenting was defined as low care and high protection. A/G polymorphism of the OXTR gene (rs53576) was detected using TaqMan SNP Genotyping Assay. Results Two‐way analysis of covariance revealed significant interaction effects between the genotype and the number of AC parents on scores of harm avoidance, with no significant main effect of genotype on any personality. Post‐hoc analysis revealed that the harm avoidance scores were increased in a stepwise manner with respect to the increase of the number of AC parents in the A allele carriers. No similar association was observed in the A allele noncarriers. Conclusion The results of this study suggest that OXTR polymorphism influences characterization of harm avoidance by moderating susceptibility to AC parenting.
format	article
author	Keisuke Noto Akihito Suzuki Toshinori Shirata Yoshihiko Matsumoto Haruka Muraosa Kaoru Goto Koichi Otani
author_facet	Keisuke Noto Akihito Suzuki Toshinori Shirata Yoshihiko Matsumoto Haruka Muraosa Kaoru Goto Koichi Otani
author_sort	Keisuke Noto
title	Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
title_short	Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
title_full	Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
title_fullStr	Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
title_full_unstemmed	Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
title_sort	oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/7f705adb9fc94391895011f1295c0138
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Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting

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