The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice

Abstract Vaginitis is very common among women, especially women of childbearing age, and is associated with significantly increased risk of preterm birth and pelvic inflammatory diseases. An imbalance in the vaginal flora, the primary cause of vaginitis, promotes the initiation and progression of va...

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Autores principales:	Lisha Jiang, Lingling Zhang, Can Rui, Xia Liu, Zhiyuan Mao, Lina Yan, Ting Luan, Xinyan Wang, Ying Wu, Ping Li, Xin Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f71858855bf4eec83454035fac2b6e1
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spelling	oai:doaj.org-article:7f71858855bf4eec83454035fac2b6e12021-12-02T15:10:04ZThe role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice10.1038/s41598-019-50902-w2045-2322https://doaj.org/article/7f71858855bf4eec83454035fac2b6e12019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50902-whttps://doaj.org/toc/2045-2322Abstract Vaginitis is very common among women, especially women of childbearing age, and is associated with significantly increased risk of preterm birth and pelvic inflammatory diseases. An imbalance in the vaginal flora, the primary cause of vaginitis, promotes the initiation and progression of vaginal infections. However, the responsible mechanisms are still poorly understood. Using a murine vaginitis model of Escherichia coli infection, we demonstrated that decreased expression of microRNA1976 and increased expression of CD105 and integrin αvβ6 were closely associated with the progression of vaginal infection. Importantly, we demonstrated for the first time that the microRNA1976/CD105/integrin αvβ6 axis regulates E. coli-mediated vaginal infection in mice, as evidenced by the finding that E. coli-induced vaginal infection was reversed by microRNA1976 overexpression and exacerbated by CD105 overexpression. The regulation of CD105 and integrin αvβ6 by microRNA1976 was further confirmed in a murine model of vaginitis with adenoviral vector treatment. Taken together, our data suggested that microRNA1976 negatively regulates E. coli-induced vaginal infection in mice at least in part by suppressing CD105 and integrin αvβ6 expression. These findings may provide new insight into the mechanisms of E. coli-induced vaginitis, identify a novel diagnostic biomarker and a potential therapeutic target for flora imbalance-associated vaginitis.Lisha JiangLingling ZhangCan RuiXia LiuZhiyuan MaoLina YanTing LuanXinyan WangYing WuPing LiXin ZengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisha Jiang Lingling Zhang Can Rui Xia Liu Zhiyuan Mao Lina Yan Ting Luan Xinyan Wang Ying Wu Ping Li Xin Zeng The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice
description	Abstract Vaginitis is very common among women, especially women of childbearing age, and is associated with significantly increased risk of preterm birth and pelvic inflammatory diseases. An imbalance in the vaginal flora, the primary cause of vaginitis, promotes the initiation and progression of vaginal infections. However, the responsible mechanisms are still poorly understood. Using a murine vaginitis model of Escherichia coli infection, we demonstrated that decreased expression of microRNA1976 and increased expression of CD105 and integrin αvβ6 were closely associated with the progression of vaginal infection. Importantly, we demonstrated for the first time that the microRNA1976/CD105/integrin αvβ6 axis regulates E. coli-mediated vaginal infection in mice, as evidenced by the finding that E. coli-induced vaginal infection was reversed by microRNA1976 overexpression and exacerbated by CD105 overexpression. The regulation of CD105 and integrin αvβ6 by microRNA1976 was further confirmed in a murine model of vaginitis with adenoviral vector treatment. Taken together, our data suggested that microRNA1976 negatively regulates E. coli-induced vaginal infection in mice at least in part by suppressing CD105 and integrin αvβ6 expression. These findings may provide new insight into the mechanisms of E. coli-induced vaginitis, identify a novel diagnostic biomarker and a potential therapeutic target for flora imbalance-associated vaginitis.
format	article
author	Lisha Jiang Lingling Zhang Can Rui Xia Liu Zhiyuan Mao Lina Yan Ting Luan Xinyan Wang Ying Wu Ping Li Xin Zeng
author_facet	Lisha Jiang Lingling Zhang Can Rui Xia Liu Zhiyuan Mao Lina Yan Ting Luan Xinyan Wang Ying Wu Ping Li Xin Zeng
author_sort	Lisha Jiang
title	The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice
title_short	The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice
title_full	The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice
title_fullStr	The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice
title_full_unstemmed	The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice
title_sort	role of the mir1976/cd105/integrin αvβ6 axis in vaginitis induced by escherichia coli infection in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7f71858855bf4eec83454035fac2b6e1
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The role of the miR1976/CD105/integrin αvβ6 axis in vaginitis induced by Escherichia coli infection in mice

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