Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands

Abstract This retrospective study investigated the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients with histopathologically confirmed SCSG between January 2010 and December 2020. In total, 13 males and 10 females (ratio, 1.3:1) aged 10 − 69 years (...

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Autores principales:	Jingjing Sun, Sirui Liu, Kun Fu, Ning Gao, Rui Li, Wei He, Zhenjie Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f718fbd44e74ca58e30cabea57a1b71
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spelling	oai:doaj.org-article:7f718fbd44e74ca58e30cabea57a1b712021-11-28T12:16:05ZClinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands10.1038/s41598-021-01970-42045-2322https://doaj.org/article/7f718fbd44e74ca58e30cabea57a1b712021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01970-4https://doaj.org/toc/2045-2322Abstract This retrospective study investigated the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients with histopathologically confirmed SCSG between January 2010 and December 2020. In total, 13 males and 10 females (ratio, 1.3:1) aged 10 − 69 years (median, 45 years) were enrolled in this study; the average disease duration was 2.44 years (0.25–20 years). Twenty-one patients (91.3%) had SCSG in the parotid gland, and two (8.7%) in the submandibular gland. All patients had single nodules of diameters 0.8–4.8 cm (average 2.6 cm); five with lymph node metastases, and two with distant metastases. Immunohistochemically, tumors stained positive for S-100, mammaglobin, CK7, GATA3 and pan-Trk, and negative for DOG1, P63, and calponin, with Ki-67 positivity from 1 to 50%. ETV6 gene rearrangement was confirmed in 15 patients. All patients underwent oncological resection, four had radioactive particles implanted postoperatively, one received chemotherapy, and seven underwent chemoradiotherapy. Six patients had regional recurrences, two distant metastases, and one died before the last follow-up. SCSGs are typically indolent, with a low locoregional recurrence rate and excellent survival. Prognosis is correlated to clinical stage, pathological grade, and surgical procedures.Jingjing SunSirui LiuKun FuNing GaoRui LiWei HeZhenjie GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jingjing Sun Sirui Liu Kun Fu Ning Gao Rui Li Wei He Zhenjie Gao Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands
description	Abstract This retrospective study investigated the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients with histopathologically confirmed SCSG between January 2010 and December 2020. In total, 13 males and 10 females (ratio, 1.3:1) aged 10 − 69 years (median, 45 years) were enrolled in this study; the average disease duration was 2.44 years (0.25–20 years). Twenty-one patients (91.3%) had SCSG in the parotid gland, and two (8.7%) in the submandibular gland. All patients had single nodules of diameters 0.8–4.8 cm (average 2.6 cm); five with lymph node metastases, and two with distant metastases. Immunohistochemically, tumors stained positive for S-100, mammaglobin, CK7, GATA3 and pan-Trk, and negative for DOG1, P63, and calponin, with Ki-67 positivity from 1 to 50%. ETV6 gene rearrangement was confirmed in 15 patients. All patients underwent oncological resection, four had radioactive particles implanted postoperatively, one received chemotherapy, and seven underwent chemoradiotherapy. Six patients had regional recurrences, two distant metastases, and one died before the last follow-up. SCSGs are typically indolent, with a low locoregional recurrence rate and excellent survival. Prognosis is correlated to clinical stage, pathological grade, and surgical procedures.
format	article
author	Jingjing Sun Sirui Liu Kun Fu Ning Gao Rui Li Wei He Zhenjie Gao
author_facet	Jingjing Sun Sirui Liu Kun Fu Ning Gao Rui Li Wei He Zhenjie Gao
author_sort	Jingjing Sun
title	Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands
title_short	Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands
title_full	Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands
title_fullStr	Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands
title_full_unstemmed	Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands
title_sort	clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f718fbd44e74ca58e30cabea57a1b71
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Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands

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