Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

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Autores principales:	Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J. Ramus, Qiyuan Li, Melissa K. Delgado, Janet M. Lee, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K. Arun, Brita Arver, Elisa V. Bandera, Monica Barile, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalia Bogdanova, Anders Bojesen, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fiona Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Saundra S. Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Canniotto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B. M. Claes, GEMO Study Collaborators, Linda S. Cook, Angela Cox, Daniel W. Cramer, Simon S. Cross, Cezary Cybulski, Kamila Czene, Mary B. Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diez, Jennifer A. Doherty, Susan M. Domchek, Cecilia M. Dorfling, Thilo Dörk, Martine Dumont, Hans Ehrencrona, Bent Ejlertsen, Steve Ellis, EMBRACE, Christoph Engel, Eunjung Lee, D. Gareth Evans, Peter A. Fasching, Lidia Feliubadalo, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lenka Foretova, Florentia Fostira, William D. Foulkes, Brooke L. Fridley, Eitan Friedman, Debra Frost, Gaetana Gambino, Patricia A. Ganz, Judy Garber, Montserrat García-Closas, Aleksandra Gentry-Maharaj, Maya Ghoussaini, Graham G. Giles, Rosalind Glasspool, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González-Neira, Ellen L. Goode, Marc T. Goodman, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Christopher A. Haiman, Per Hall, Emily Hallberg, Ute Hamann, Thomas V. O. Hansen, Patricia A. Harrington, Mikael Hartman, Norhashimah Hassan, Sue Healey, The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Florian Heitz, Josef Herzog, Estrid Høgdall, Claus K. Høgdall, Frans B. L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Peter J. Hulick, Tomasz Huzarski, Evgeny N. Imyanitov, KConFab Investigators, Australian Ovarian Cancer Study Group, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Allan Jensen, Esther M. John, Nichola Johnson, Maria Kabisch, Daehee Kang, Miroslav Kapuscinski, Beth Y. Karlan, Sofia Khan, Lambertus A. Kiemeney, Susanne Kruger Kjaer, Julia A. Knight, Irene Konstantopoulou, Veli-Matti Kosma, Vessela Kristensen, Jolanta Kupryjanczyk, Ava Kwong, Miguel de la Hoya, Yael Laitman, Diether Lambrechts, Nhu Le, Kim De Leeneer, Jenny Lester, Douglas A. Levine, Jingmei Li, Annika Lindblom, Jirong Long, Artitaya Lophatananon, Jennifer T. Loud, Karen Lu, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Loic Le Marchand, Sara Margolin, Frederik Marme, Leon F. A. G. Massuger, Keitaro Matsuo, Sylvie Mazoyer, Lesley McGuffog, Catriona McLean, Iain McNeish, Alfons Meindl, Usha Menon, Arjen R. Mensenkamp, Roger L. Milne, Marco Montagna, Kirsten B. Moysich, Kenneth Muir, Anna Marie Mulligan, Katherine L. Nathanson, Roberta B. Ness, Susan L. Neuhausen, Heli Nevanlinna, Silje Nord, Robert L. Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Janet E. Olson, Curtis Olswold, David O’Malley, Irene Orlow, Nick Orr, Ana Osorio, Sue Kyung Park, Celeste L. Pearce, Tanja Pejovic, Paolo Peterlongo, Georg Pfeiler, Catherine M. Phelan, Elizabeth M. Poole, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Valerie Rhenius, Kerstin Rhiem, Harvey A. Risch, Gus Rodriguez, Mary Anne Rossing, Anja Rudolph, Helga B. Salvesen, Suleeporn Sangrajrang, Elinor J. Sawyer, Joellen M. Schildkraut, Marjanka K. Schmidt, Rita K. Schmutzler, Thomas A. Sellers, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Weiva Sieh, Christian F. Singer, Olga M. Sinilnikova, Susan Slager, Honglin Song, Penny Soucy, Melissa C. Southey, Marie Stenmark-Askmalm, Dominique Stoppa-Lyonnet, Christian Sutter, Anthony Swerdlow, Sandrine Tchatchou, Manuel R. Teixeira, Soo H. Teo, Kathryn L. Terry, Mary Beth Terry, Mads Thomassen, Maria Grazia Tibiletti, Laima Tihomirova, Silvia Tognazzo, Amanda Ewart Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-chen Tseng, Nadine Tung, Shelley S. Tworoger, Celine Vachon, Ans M. W. van den Ouweland, Helena C. van Doorn, Elizabeth J. van Rensburg, Laura J. Van't Veer, Adriaan Vanderstichele, Ignace Vergote, Joseph Vijai, Qin Wang, Shan Wang-Gohrke, Jeffrey N. Weitzel, Nicolas Wentzensen, Alice S. Whittemore, Hans Wildiers, Robert Winqvist, Anna H. Wu, Drakoulis Yannoukakos, Sook-Yee Yoon, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Kum Kum Khanna, Jacques Simard, Alvaro N. Monteiro, Juliet D. French, Fergus J. Couch, Matthew L. Freedman, Douglas F. Easton, Alison M. Dunning, Paul D. Pharoah, Stacey L. Edwards, Georgia Chenevix-Trench, Antonis C. Antoniou, Simon A. Gayther
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f7ca2a3e022413db18aa0dafbffc2d4
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record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kate Lawrenson Siddhartha Kar Karen McCue Karoline Kuchenbaeker Kyriaki Michailidou Jonathan Tyrer Jonathan Beesley Susan J. Ramus Qiyuan Li Melissa K. Delgado Janet M. Lee Kristiina Aittomäki Irene L. Andrulis Hoda Anton-Culver Volker Arndt Banu K. Arun Brita Arver Elisa V. Bandera Monica Barile Rosa B. Barkardottir Daniel Barrowdale Matthias W. Beckmann Javier Benitez Andrew Berchuck Maria Bisogna Line Bjorge Carl Blomqvist William Blot Natalia Bogdanova Anders Bojesen Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Paul Brennan Hermann Brenner Fiona Bruinsma Joan Brunet Shaik Ahmad Buhari Barbara Burwinkel Ralf Butzow Saundra S. Buys Qiuyin Cai Trinidad Caldes Ian Campbell Rikki Canniotto Jenny Chang-Claude Jocelyne Chiquette Ji-Yeob Choi Kathleen B. M. Claes GEMO Study Collaborators Linda S. Cook Angela Cox Daniel W. Cramer Simon S. Cross Cezary Cybulski Kamila Czene Mary B. Daly Francesca Damiola Agnieszka Dansonka-Mieszkowska Hatef Darabi Joe Dennis Peter Devilee Orland Diez Jennifer A. Doherty Susan M. Domchek Cecilia M. Dorfling Thilo Dörk Martine Dumont Hans Ehrencrona Bent Ejlertsen Steve Ellis EMBRACE Christoph Engel Eunjung Lee D. Gareth Evans Peter A. Fasching Lidia Feliubadalo Jonine Figueroa Dieter Flesch-Janys Olivia Fletcher Henrik Flyger Lenka Foretova Florentia Fostira William D. Foulkes Brooke L. Fridley Eitan Friedman Debra Frost Gaetana Gambino Patricia A. Ganz Judy Garber Montserrat García-Closas Aleksandra Gentry-Maharaj Maya Ghoussaini Graham G. Giles Rosalind Glasspool Andrew K. Godwin Mark S. Goldberg David E. Goldgar Anna González-Neira Ellen L. Goode Marc T. Goodman Mark H. Greene Jacek Gronwald Pascal Guénel Christopher A. Haiman Per Hall Emily Hallberg Ute Hamann Thomas V. O. Hansen Patricia A. Harrington Mikael Hartman Norhashimah Hassan Sue Healey The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) Florian Heitz Josef Herzog Estrid Høgdall Claus K. Høgdall Frans B. L. Hogervorst Antoinette Hollestelle John L. Hopper Peter J. Hulick Tomasz Huzarski Evgeny N. Imyanitov KConFab Investigators Australian Ovarian Cancer Study Group Claudine Isaacs Hidemi Ito Anna Jakubowska Ramunas Janavicius Allan Jensen Esther M. John Nichola Johnson Maria Kabisch Daehee Kang Miroslav Kapuscinski Beth Y. Karlan Sofia Khan Lambertus A. Kiemeney Susanne Kruger Kjaer Julia A. Knight Irene Konstantopoulou Veli-Matti Kosma Vessela Kristensen Jolanta Kupryjanczyk Ava Kwong Miguel de la Hoya Yael Laitman Diether Lambrechts Nhu Le Kim De Leeneer Jenny Lester Douglas A. Levine Jingmei Li Annika Lindblom Jirong Long Artitaya Lophatananon Jennifer T. Loud Karen Lu Jan Lubinski Arto Mannermaa Siranoush Manoukian Loic Le Marchand Sara Margolin Frederik Marme Leon F. A. G. Massuger Keitaro Matsuo Sylvie Mazoyer Lesley McGuffog Catriona McLean Iain McNeish Alfons Meindl Usha Menon Arjen R. Mensenkamp Roger L. Milne Marco Montagna Kirsten B. Moysich Kenneth Muir Anna Marie Mulligan Katherine L. Nathanson Roberta B. Ness Susan L. Neuhausen Heli Nevanlinna Silje Nord Robert L. Nussbaum Kunle Odunsi Kenneth Offit Edith Olah Olufunmilayo I. Olopade Janet E. Olson Curtis Olswold David O’Malley Irene Orlow Nick Orr Ana Osorio Sue Kyung Park Celeste L. Pearce Tanja Pejovic Paolo Peterlongo Georg Pfeiler Catherine M. Phelan Elizabeth M. Poole Katri Pylkäs Paolo Radice Johanna Rantala Muhammad Usman Rashid Gad Rennert Valerie Rhenius Kerstin Rhiem Harvey A. Risch Gus Rodriguez Mary Anne Rossing Anja Rudolph Helga B. Salvesen Suleeporn Sangrajrang Elinor J. Sawyer Joellen M. Schildkraut Marjanka K. Schmidt Rita K. Schmutzler Thomas A. Sellers Caroline Seynaeve Mitul Shah Chen-Yang Shen Xiao-Ou Shu Weiva Sieh Christian F. Singer Olga M. Sinilnikova Susan Slager Honglin Song Penny Soucy Melissa C. Southey Marie Stenmark-Askmalm Dominique Stoppa-Lyonnet Christian Sutter Anthony Swerdlow Sandrine Tchatchou Manuel R. Teixeira Soo H. Teo Kathryn L. Terry Mary Beth Terry Mads Thomassen Maria Grazia Tibiletti Laima Tihomirova Silvia Tognazzo Amanda Ewart Toland Ian Tomlinson Diana Torres Thérèse Truong Chiu-chen Tseng Nadine Tung Shelley S. Tworoger Celine Vachon Ans M. W. van den Ouweland Helena C. van Doorn Elizabeth J. van Rensburg Laura J. Van't Veer Adriaan Vanderstichele Ignace Vergote Joseph Vijai Qin Wang Shan Wang-Gohrke Jeffrey N. Weitzel Nicolas Wentzensen Alice S. Whittemore Hans Wildiers Robert Winqvist Anna H. Wu Drakoulis Yannoukakos Sook-Yee Yoon Jyh-Cherng Yu Wei Zheng Ying Zheng Kum Kum Khanna Jacques Simard Alvaro N. Monteiro Juliet D. French Fergus J. Couch Matthew L. Freedman Douglas F. Easton Alison M. Dunning Paul D. Pharoah Stacey L. Edwards Georgia Chenevix-Trench Antonis C. Antoniou Simon A. Gayther Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
description	A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.
format	article
author	Kate Lawrenson Siddhartha Kar Karen McCue Karoline Kuchenbaeker Kyriaki Michailidou Jonathan Tyrer Jonathan Beesley Susan J. Ramus Qiyuan Li Melissa K. Delgado Janet M. Lee Kristiina Aittomäki Irene L. Andrulis Hoda Anton-Culver Volker Arndt Banu K. Arun Brita Arver Elisa V. Bandera Monica Barile Rosa B. Barkardottir Daniel Barrowdale Matthias W. Beckmann Javier Benitez Andrew Berchuck Maria Bisogna Line Bjorge Carl Blomqvist William Blot Natalia Bogdanova Anders Bojesen Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Paul Brennan Hermann Brenner Fiona Bruinsma Joan Brunet Shaik Ahmad Buhari Barbara Burwinkel Ralf Butzow Saundra S. Buys Qiuyin Cai Trinidad Caldes Ian Campbell Rikki Canniotto Jenny Chang-Claude Jocelyne Chiquette Ji-Yeob Choi Kathleen B. M. Claes GEMO Study Collaborators Linda S. Cook Angela Cox Daniel W. Cramer Simon S. Cross Cezary Cybulski Kamila Czene Mary B. Daly Francesca Damiola Agnieszka Dansonka-Mieszkowska Hatef Darabi Joe Dennis Peter Devilee Orland Diez Jennifer A. Doherty Susan M. Domchek Cecilia M. Dorfling Thilo Dörk Martine Dumont Hans Ehrencrona Bent Ejlertsen Steve Ellis EMBRACE Christoph Engel Eunjung Lee D. Gareth Evans Peter A. Fasching Lidia Feliubadalo Jonine Figueroa Dieter Flesch-Janys Olivia Fletcher Henrik Flyger Lenka Foretova Florentia Fostira William D. Foulkes Brooke L. Fridley Eitan Friedman Debra Frost Gaetana Gambino Patricia A. Ganz Judy Garber Montserrat García-Closas Aleksandra Gentry-Maharaj Maya Ghoussaini Graham G. Giles Rosalind Glasspool Andrew K. Godwin Mark S. Goldberg David E. Goldgar Anna González-Neira Ellen L. Goode Marc T. Goodman Mark H. Greene Jacek Gronwald Pascal Guénel Christopher A. Haiman Per Hall Emily Hallberg Ute Hamann Thomas V. O. Hansen Patricia A. Harrington Mikael Hartman Norhashimah Hassan Sue Healey The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) Florian Heitz Josef Herzog Estrid Høgdall Claus K. Høgdall Frans B. L. Hogervorst Antoinette Hollestelle John L. Hopper Peter J. Hulick Tomasz Huzarski Evgeny N. Imyanitov KConFab Investigators Australian Ovarian Cancer Study Group Claudine Isaacs Hidemi Ito Anna Jakubowska Ramunas Janavicius Allan Jensen Esther M. John Nichola Johnson Maria Kabisch Daehee Kang Miroslav Kapuscinski Beth Y. Karlan Sofia Khan Lambertus A. Kiemeney Susanne Kruger Kjaer Julia A. Knight Irene Konstantopoulou Veli-Matti Kosma Vessela Kristensen Jolanta Kupryjanczyk Ava Kwong Miguel de la Hoya Yael Laitman Diether Lambrechts Nhu Le Kim De Leeneer Jenny Lester Douglas A. Levine Jingmei Li Annika Lindblom Jirong Long Artitaya Lophatananon Jennifer T. Loud Karen Lu Jan Lubinski Arto Mannermaa Siranoush Manoukian Loic Le Marchand Sara Margolin Frederik Marme Leon F. A. G. Massuger Keitaro Matsuo Sylvie Mazoyer Lesley McGuffog Catriona McLean Iain McNeish Alfons Meindl Usha Menon Arjen R. Mensenkamp Roger L. Milne Marco Montagna Kirsten B. Moysich Kenneth Muir Anna Marie Mulligan Katherine L. Nathanson Roberta B. Ness Susan L. Neuhausen Heli Nevanlinna Silje Nord Robert L. Nussbaum Kunle Odunsi Kenneth Offit Edith Olah Olufunmilayo I. Olopade Janet E. Olson Curtis Olswold David O’Malley Irene Orlow Nick Orr Ana Osorio Sue Kyung Park Celeste L. Pearce Tanja Pejovic Paolo Peterlongo Georg Pfeiler Catherine M. Phelan Elizabeth M. Poole Katri Pylkäs Paolo Radice Johanna Rantala Muhammad Usman Rashid Gad Rennert Valerie Rhenius Kerstin Rhiem Harvey A. Risch Gus Rodriguez Mary Anne Rossing Anja Rudolph Helga B. Salvesen Suleeporn Sangrajrang Elinor J. Sawyer Joellen M. Schildkraut Marjanka K. Schmidt Rita K. Schmutzler Thomas A. Sellers Caroline Seynaeve Mitul Shah Chen-Yang Shen Xiao-Ou Shu Weiva Sieh Christian F. Singer Olga M. Sinilnikova Susan Slager Honglin Song Penny Soucy Melissa C. Southey Marie Stenmark-Askmalm Dominique Stoppa-Lyonnet Christian Sutter Anthony Swerdlow Sandrine Tchatchou Manuel R. Teixeira Soo H. Teo Kathryn L. Terry Mary Beth Terry Mads Thomassen Maria Grazia Tibiletti Laima Tihomirova Silvia Tognazzo Amanda Ewart Toland Ian Tomlinson Diana Torres Thérèse Truong Chiu-chen Tseng Nadine Tung Shelley S. Tworoger Celine Vachon Ans M. W. van den Ouweland Helena C. van Doorn Elizabeth J. van Rensburg Laura J. Van't Veer Adriaan Vanderstichele Ignace Vergote Joseph Vijai Qin Wang Shan Wang-Gohrke Jeffrey N. Weitzel Nicolas Wentzensen Alice S. Whittemore Hans Wildiers Robert Winqvist Anna H. Wu Drakoulis Yannoukakos Sook-Yee Yoon Jyh-Cherng Yu Wei Zheng Ying Zheng Kum Kum Khanna Jacques Simard Alvaro N. Monteiro Juliet D. French Fergus J. Couch Matthew L. Freedman Douglas F. Easton Alison M. Dunning Paul D. Pharoah Stacey L. Edwards Georgia Chenevix-Trench Antonis C. Antoniou Simon A. Gayther
author_facet	Kate Lawrenson Siddhartha Kar Karen McCue Karoline Kuchenbaeker Kyriaki Michailidou Jonathan Tyrer Jonathan Beesley Susan J. Ramus Qiyuan Li Melissa K. Delgado Janet M. Lee Kristiina Aittomäki Irene L. Andrulis Hoda Anton-Culver Volker Arndt Banu K. Arun Brita Arver Elisa V. Bandera Monica Barile Rosa B. Barkardottir Daniel Barrowdale Matthias W. Beckmann Javier Benitez Andrew Berchuck Maria Bisogna Line Bjorge Carl Blomqvist William Blot Natalia Bogdanova Anders Bojesen Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Paul Brennan Hermann Brenner Fiona Bruinsma Joan Brunet Shaik Ahmad Buhari Barbara Burwinkel Ralf Butzow Saundra S. Buys Qiuyin Cai Trinidad Caldes Ian Campbell Rikki Canniotto Jenny Chang-Claude Jocelyne Chiquette Ji-Yeob Choi Kathleen B. M. Claes GEMO Study Collaborators Linda S. Cook Angela Cox Daniel W. Cramer Simon S. Cross Cezary Cybulski Kamila Czene Mary B. Daly Francesca Damiola Agnieszka Dansonka-Mieszkowska Hatef Darabi Joe Dennis Peter Devilee Orland Diez Jennifer A. Doherty Susan M. Domchek Cecilia M. Dorfling Thilo Dörk Martine Dumont Hans Ehrencrona Bent Ejlertsen Steve Ellis EMBRACE Christoph Engel Eunjung Lee D. Gareth Evans Peter A. Fasching Lidia Feliubadalo Jonine Figueroa Dieter Flesch-Janys Olivia Fletcher Henrik Flyger Lenka Foretova Florentia Fostira William D. Foulkes Brooke L. Fridley Eitan Friedman Debra Frost Gaetana Gambino Patricia A. Ganz Judy Garber Montserrat García-Closas Aleksandra Gentry-Maharaj Maya Ghoussaini Graham G. Giles Rosalind Glasspool Andrew K. Godwin Mark S. Goldberg David E. Goldgar Anna González-Neira Ellen L. Goode Marc T. Goodman Mark H. Greene Jacek Gronwald Pascal Guénel Christopher A. Haiman Per Hall Emily Hallberg Ute Hamann Thomas V. O. Hansen Patricia A. Harrington Mikael Hartman Norhashimah Hassan Sue Healey The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) Florian Heitz Josef Herzog Estrid Høgdall Claus K. Høgdall Frans B. L. Hogervorst Antoinette Hollestelle John L. Hopper Peter J. Hulick Tomasz Huzarski Evgeny N. Imyanitov KConFab Investigators Australian Ovarian Cancer Study Group Claudine Isaacs Hidemi Ito Anna Jakubowska Ramunas Janavicius Allan Jensen Esther M. John Nichola Johnson Maria Kabisch Daehee Kang Miroslav Kapuscinski Beth Y. Karlan Sofia Khan Lambertus A. Kiemeney Susanne Kruger Kjaer Julia A. Knight Irene Konstantopoulou Veli-Matti Kosma Vessela Kristensen Jolanta Kupryjanczyk Ava Kwong Miguel de la Hoya Yael Laitman Diether Lambrechts Nhu Le Kim De Leeneer Jenny Lester Douglas A. Levine Jingmei Li Annika Lindblom Jirong Long Artitaya Lophatananon Jennifer T. Loud Karen Lu Jan Lubinski Arto Mannermaa Siranoush Manoukian Loic Le Marchand Sara Margolin Frederik Marme Leon F. A. G. Massuger Keitaro Matsuo Sylvie Mazoyer Lesley McGuffog Catriona McLean Iain McNeish Alfons Meindl Usha Menon Arjen R. Mensenkamp Roger L. Milne Marco Montagna Kirsten B. Moysich Kenneth Muir Anna Marie Mulligan Katherine L. Nathanson Roberta B. Ness Susan L. Neuhausen Heli Nevanlinna Silje Nord Robert L. Nussbaum Kunle Odunsi Kenneth Offit Edith Olah Olufunmilayo I. Olopade Janet E. Olson Curtis Olswold David O’Malley Irene Orlow Nick Orr Ana Osorio Sue Kyung Park Celeste L. Pearce Tanja Pejovic Paolo Peterlongo Georg Pfeiler Catherine M. Phelan Elizabeth M. Poole Katri Pylkäs Paolo Radice Johanna Rantala Muhammad Usman Rashid Gad Rennert Valerie Rhenius Kerstin Rhiem Harvey A. Risch Gus Rodriguez Mary Anne Rossing Anja Rudolph Helga B. Salvesen Suleeporn Sangrajrang Elinor J. Sawyer Joellen M. Schildkraut Marjanka K. Schmidt Rita K. Schmutzler Thomas A. Sellers Caroline Seynaeve Mitul Shah Chen-Yang Shen Xiao-Ou Shu Weiva Sieh Christian F. Singer Olga M. Sinilnikova Susan Slager Honglin Song Penny Soucy Melissa C. Southey Marie Stenmark-Askmalm Dominique Stoppa-Lyonnet Christian Sutter Anthony Swerdlow Sandrine Tchatchou Manuel R. Teixeira Soo H. Teo Kathryn L. Terry Mary Beth Terry Mads Thomassen Maria Grazia Tibiletti Laima Tihomirova Silvia Tognazzo Amanda Ewart Toland Ian Tomlinson Diana Torres Thérèse Truong Chiu-chen Tseng Nadine Tung Shelley S. Tworoger Celine Vachon Ans M. W. van den Ouweland Helena C. van Doorn Elizabeth J. van Rensburg Laura J. Van't Veer Adriaan Vanderstichele Ignace Vergote Joseph Vijai Qin Wang Shan Wang-Gohrke Jeffrey N. Weitzel Nicolas Wentzensen Alice S. Whittemore Hans Wildiers Robert Winqvist Anna H. Wu Drakoulis Yannoukakos Sook-Yee Yoon Jyh-Cherng Yu Wei Zheng Ying Zheng Kum Kum Khanna Jacques Simard Alvaro N. Monteiro Juliet D. French Fergus J. Couch Matthew L. Freedman Douglas F. Easton Alison M. Dunning Paul D. Pharoah Stacey L. Edwards Georgia Chenevix-Trench Antonis C. Antoniou Simon A. Gayther
author_sort	Kate Lawrenson
title	Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
title_short	Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
title_full	Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
title_fullStr	Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
title_full_unstemmed	Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
title_sort	functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7f7ca2a3e022413db18aa0dafbffc2d4
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spelling	oai:doaj.org-article:7f7ca2a3e022413db18aa0dafbffc2d42021-12-02T15:35:25ZFunctional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus10.1038/ncomms126752041-1723https://doaj.org/article/7f7ca2a3e022413db18aa0dafbffc2d42016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12675https://doaj.org/toc/2041-1723A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.Kate LawrensonSiddhartha KarKaren McCueKaroline KuchenbaekerKyriaki MichailidouJonathan TyrerJonathan BeesleySusan J. RamusQiyuan LiMelissa K. DelgadoJanet M. LeeKristiina AittomäkiIrene L. AndrulisHoda Anton-CulverVolker ArndtBanu K. ArunBrita ArverElisa V. BanderaMonica BarileRosa B. BarkardottirDaniel BarrowdaleMatthias W. BeckmannJavier BenitezAndrew BerchuckMaria BisognaLine BjorgeCarl BlomqvistWilliam BlotNatalia BogdanovaAnders BojesenStig E. BojesenManjeet K. BollaBernardo BonanniAnne-Lise Børresen-DaleHiltrud BrauchPaul BrennanHermann BrennerFiona BruinsmaJoan BrunetShaik Ahmad BuhariBarbara BurwinkelRalf ButzowSaundra S. BuysQiuyin CaiTrinidad CaldesIan CampbellRikki CanniottoJenny Chang-ClaudeJocelyne ChiquetteJi-Yeob ChoiKathleen B. M. ClaesGEMO Study CollaboratorsLinda S. CookAngela CoxDaniel W. CramerSimon S. CrossCezary CybulskiKamila CzeneMary B. DalyFrancesca DamiolaAgnieszka Dansonka-MieszkowskaHatef DarabiJoe DennisPeter DevileeOrland DiezJennifer A. DohertySusan M. DomchekCecilia M. DorflingThilo DörkMartine DumontHans EhrencronaBent EjlertsenSteve EllisEMBRACEChristoph EngelEunjung LeeD. Gareth EvansPeter A. FaschingLidia FeliubadaloJonine FigueroaDieter Flesch-JanysOlivia FletcherHenrik FlygerLenka ForetovaFlorentia FostiraWilliam D. FoulkesBrooke L. FridleyEitan FriedmanDebra FrostGaetana GambinoPatricia A. GanzJudy GarberMontserrat García-ClosasAleksandra Gentry-MaharajMaya GhoussainiGraham G. GilesRosalind GlasspoolAndrew K. GodwinMark S. GoldbergDavid E. GoldgarAnna González-NeiraEllen L. GoodeMarc T. GoodmanMark H. GreeneJacek GronwaldPascal GuénelChristopher A. HaimanPer HallEmily HallbergUte HamannThomas V. O. HansenPatricia A. HarringtonMikael HartmanNorhashimah HassanSue HealeyThe Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)Florian HeitzJosef HerzogEstrid HøgdallClaus K. HøgdallFrans B. L. HogervorstAntoinette HollestelleJohn L. HopperPeter J. HulickTomasz HuzarskiEvgeny N. ImyanitovKConFab InvestigatorsAustralian Ovarian Cancer Study GroupClaudine IsaacsHidemi ItoAnna JakubowskaRamunas JanaviciusAllan JensenEsther M. JohnNichola JohnsonMaria KabischDaehee KangMiroslav KapuscinskiBeth Y. KarlanSofia KhanLambertus A. KiemeneySusanne Kruger KjaerJulia A. KnightIrene KonstantopoulouVeli-Matti KosmaVessela KristensenJolanta KupryjanczykAva KwongMiguel de la HoyaYael LaitmanDiether LambrechtsNhu LeKim De LeeneerJenny LesterDouglas A. LevineJingmei LiAnnika LindblomJirong LongArtitaya LophatananonJennifer T. LoudKaren LuJan LubinskiArto MannermaaSiranoush ManoukianLoic Le MarchandSara MargolinFrederik MarmeLeon F. A. G. MassugerKeitaro MatsuoSylvie MazoyerLesley McGuffogCatriona McLeanIain McNeishAlfons MeindlUsha MenonArjen R. MensenkampRoger L. MilneMarco MontagnaKirsten B. MoysichKenneth MuirAnna Marie MulliganKatherine L. NathansonRoberta B. NessSusan L. NeuhausenHeli NevanlinnaSilje NordRobert L. NussbaumKunle OdunsiKenneth OffitEdith OlahOlufunmilayo I. OlopadeJanet E. OlsonCurtis OlswoldDavid O’MalleyIrene OrlowNick OrrAna OsorioSue Kyung ParkCeleste L. PearceTanja PejovicPaolo PeterlongoGeorg PfeilerCatherine M. PhelanElizabeth M. PooleKatri PylkäsPaolo RadiceJohanna RantalaMuhammad Usman RashidGad RennertValerie RheniusKerstin RhiemHarvey A. RischGus RodriguezMary Anne RossingAnja RudolphHelga B. SalvesenSuleeporn SangrajrangElinor J. SawyerJoellen M. SchildkrautMarjanka K. SchmidtRita K. SchmutzlerThomas A. SellersCaroline SeynaeveMitul ShahChen-Yang ShenXiao-Ou ShuWeiva SiehChristian F. SingerOlga M. SinilnikovaSusan SlagerHonglin SongPenny SoucyMelissa C. SoutheyMarie Stenmark-AskmalmDominique Stoppa-LyonnetChristian SutterAnthony SwerdlowSandrine TchatchouManuel R. TeixeiraSoo H. TeoKathryn L. TerryMary Beth TerryMads ThomassenMaria Grazia TibilettiLaima TihomirovaSilvia TognazzoAmanda Ewart TolandIan TomlinsonDiana TorresThérèse TruongChiu-chen TsengNadine TungShelley S. TworogerCeline VachonAns M. W. van den OuwelandHelena C. van DoornElizabeth J. van RensburgLaura J. Van't VeerAdriaan VandersticheleIgnace VergoteJoseph VijaiQin WangShan Wang-GohrkeJeffrey N. WeitzelNicolas WentzensenAlice S. WhittemoreHans WildiersRobert WinqvistAnna H. WuDrakoulis YannoukakosSook-Yee YoonJyh-Cherng YuWei ZhengYing ZhengKum Kum KhannaJacques SimardAlvaro N. MonteiroJuliet D. FrenchFergus J. CouchMatthew L. FreedmanDouglas F. EastonAlison M. DunningPaul D. PharoahStacey L. EdwardsGeorgia Chenevix-TrenchAntonis C. AntoniouSimon A. GaytherNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-22 (2016)

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

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