Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?

Drew H Barzman1, Avni Patel2, Loretta Sonnier1, Jeffrey R Strawn31Division of Child and Adolescent Psychiatry, Cincinnati Children&rsquo;s Hospital Medical Center, Cincinnati, OH, USA; 2Miami University, Oxford, OH, USA; 3Department of Psychiatry, University of Cincinnati, College of Medicin...

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Autores principales:	Drew H Barzman, Avni Patel, Loretta Sonnier, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7f82edd77c104e898d9838c870555944
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spelling	oai:doaj.org-article:7f82edd77c104e898d9838c8705559442021-12-02T03:16:32ZNeuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?1176-63281178-2021https://doaj.org/article/7f82edd77c104e898d9838c8705559442010-10-01T00:00:00Zhttp://www.dovepress.com/neuroendocrine-aspects-of-pediatric-aggression-can-hormone-measures-be-a5467https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Drew H Barzman1, Avni Patel2, Loretta Sonnier1, Jeffrey R Strawn31Division of Child and Adolescent Psychiatry, Cincinnati Children&rsquo;s Hospital Medical Center, Cincinnati, OH, USA; 2Miami University, Oxford, OH, USA; 3Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH, USAAbstract: Pediatric aggression is common in human societies, mainly presenting as impulsive aggression or predatory aggression. Numerous psychiatric disorders can contain aggression as a symptom, leading to difficulties in diagnosis and treatment. This review focuses on the biological systems that affect pediatric aggression. We review the hypothalamic&ndash;pituitary&ndash;adrenal (HPA) axis, the hypothalamic&ndash;pituitary&ndash;gonadal (HPG) axis, and the mechanisms by which these axes influence the body and mind of aggressive children and adolescents. Although this review focuses on the HPA and HPG axes, it is important to note that other biological systems have relationships with these two axes. Based on the results of the studies reviewed, elevated cortisol concentrations were associated with impulsive aggression, whereas, low levels of cortisol were associated with callous-unemotional traits similar to predatory aggression. Higher levels of dehydroepiandrosterone were correlated with higher levels of aggression as were higher levels of testosterone. However, there have been discrepancies in the results between various studies, indicating the need for more research on hormonal levels and pediatric aggression. In the future, hormonal levels may be useful in determining what treatments will work best for certain pediatric patients.Keywords: youth, cortisol, adrenocorticotropin-releasing hormone, corticotropin-releasing hormone, HPA axis, HPG axis Drew H BarzmanAvni PatelLoretta Sonnieret alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 691-697 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Drew H Barzman Avni Patel Loretta Sonnier et al Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?
description	Drew H Barzman1, Avni Patel2, Loretta Sonnier1, Jeffrey R Strawn31Division of Child and Adolescent Psychiatry, Cincinnati Children&rsquo;s Hospital Medical Center, Cincinnati, OH, USA; 2Miami University, Oxford, OH, USA; 3Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH, USAAbstract: Pediatric aggression is common in human societies, mainly presenting as impulsive aggression or predatory aggression. Numerous psychiatric disorders can contain aggression as a symptom, leading to difficulties in diagnosis and treatment. This review focuses on the biological systems that affect pediatric aggression. We review the hypothalamic&ndash;pituitary&ndash;adrenal (HPA) axis, the hypothalamic&ndash;pituitary&ndash;gonadal (HPG) axis, and the mechanisms by which these axes influence the body and mind of aggressive children and adolescents. Although this review focuses on the HPA and HPG axes, it is important to note that other biological systems have relationships with these two axes. Based on the results of the studies reviewed, elevated cortisol concentrations were associated with impulsive aggression, whereas, low levels of cortisol were associated with callous-unemotional traits similar to predatory aggression. Higher levels of dehydroepiandrosterone were correlated with higher levels of aggression as were higher levels of testosterone. However, there have been discrepancies in the results between various studies, indicating the need for more research on hormonal levels and pediatric aggression. In the future, hormonal levels may be useful in determining what treatments will work best for certain pediatric patients.Keywords: youth, cortisol, adrenocorticotropin-releasing hormone, corticotropin-releasing hormone, HPA axis, HPG axis
format	article
author	Drew H Barzman Avni Patel Loretta Sonnier et al
author_facet	Drew H Barzman Avni Patel Loretta Sonnier et al
author_sort	Drew H Barzman
title	Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?
title_short	Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?
title_full	Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?
title_fullStr	Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?
title_full_unstemmed	Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?
title_sort	neuroendocrine aspects of pediatric aggression: can hormone measures be clinically useful?
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/7f82edd77c104e898d9838c870555944
work_keys_str_mv	AT drewhbarzman neuroendocrineaspectsofpediatricaggressioncanhormonemeasuresbeclinicallyuseful AT avnipatel neuroendocrineaspectsofpediatricaggressioncanhormonemeasuresbeclinicallyuseful AT lorettasonnier neuroendocrineaspectsofpediatricaggressioncanhormonemeasuresbeclinicallyuseful AT etal neuroendocrineaspectsofpediatricaggressioncanhormonemeasuresbeclinicallyuseful
_version_	1718401866248749056

Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful?

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