Shifting the optimal stiffness for cell migration

Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches, and verify their model in two cell types.

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Detalles Bibliográficos
Autores principales:	Benjamin L. Bangasser, Ghaidan A. Shamsan, Clarence E. Chan, Kwaku N. Opoku, Erkan Tüzel, Benjamin W. Schlichtmann, Jesse A. Kasim, Benjamin J. Fuller, Brannon R. McCullough, Steven S. Rosenfeld, David J. Odde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f8be4a890ad4dfa87e307c6843951c7
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spelling	oai:doaj.org-article:7f8be4a890ad4dfa87e307c6843951c72021-12-02T14:40:34ZShifting the optimal stiffness for cell migration10.1038/ncomms153132041-1723https://doaj.org/article/7f8be4a890ad4dfa87e307c6843951c72017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15313https://doaj.org/toc/2041-1723Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches, and verify their model in two cell types.Benjamin L. BangasserGhaidan A. ShamsanClarence E. ChanKwaku N. OpokuErkan TüzelBenjamin W. SchlichtmannJesse A. KasimBenjamin J. FullerBrannon R. McCulloughSteven S. RosenfeldDavid J. OddeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin L. Bangasser Ghaidan A. Shamsan Clarence E. Chan Kwaku N. Opoku Erkan Tüzel Benjamin W. Schlichtmann Jesse A. Kasim Benjamin J. Fuller Brannon R. McCullough Steven S. Rosenfeld David J. Odde Shifting the optimal stiffness for cell migration
description	Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches, and verify their model in two cell types.
format	article
author	Benjamin L. Bangasser Ghaidan A. Shamsan Clarence E. Chan Kwaku N. Opoku Erkan Tüzel Benjamin W. Schlichtmann Jesse A. Kasim Benjamin J. Fuller Brannon R. McCullough Steven S. Rosenfeld David J. Odde
author_facet	Benjamin L. Bangasser Ghaidan A. Shamsan Clarence E. Chan Kwaku N. Opoku Erkan Tüzel Benjamin W. Schlichtmann Jesse A. Kasim Benjamin J. Fuller Brannon R. McCullough Steven S. Rosenfeld David J. Odde
author_sort	Benjamin L. Bangasser
title	Shifting the optimal stiffness for cell migration
title_short	Shifting the optimal stiffness for cell migration
title_full	Shifting the optimal stiffness for cell migration
title_fullStr	Shifting the optimal stiffness for cell migration
title_full_unstemmed	Shifting the optimal stiffness for cell migration
title_sort	shifting the optimal stiffness for cell migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f8be4a890ad4dfa87e307c6843951c7
work_keys_str_mv	AT benjaminlbangasser shiftingtheoptimalstiffnessforcellmigration AT ghaidanashamsan shiftingtheoptimalstiffnessforcellmigration AT clarenceechan shiftingtheoptimalstiffnessforcellmigration AT kwakunopoku shiftingtheoptimalstiffnessforcellmigration AT erkantuzel shiftingtheoptimalstiffnessforcellmigration AT benjaminwschlichtmann shiftingtheoptimalstiffnessforcellmigration AT jesseakasim shiftingtheoptimalstiffnessforcellmigration AT benjaminjfuller shiftingtheoptimalstiffnessforcellmigration AT brannonrmccullough shiftingtheoptimalstiffnessforcellmigration AT stevensrosenfeld shiftingtheoptimalstiffnessforcellmigration AT davidjodde shiftingtheoptimalstiffnessforcellmigration
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Shifting the optimal stiffness for cell migration

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