Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner

Magnetic actuation of medical devices is of great interest in improving minimally invasive surgery and enabling targeted drug delivery. With untethered, magnetically coated swimmers it is aimed at reaching regions of the body difficult to access with catheters. Such a swimmer was previously presente...

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Autores principales:	Bakenecker Anna C., Chinchilla Carlos, Buzug Thorsten M.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	magnetic actuation magnetic manipulation magnetic particle imaging mpi magnetic nanoparticles magnetic swimmer Medicine R
Acceso en línea:	https://doaj.org/article/7f8f0de10ea14a10b11045304ff3a340
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spelling	oai:doaj.org-article:7f8f0de10ea14a10b11045304ff3a3402021-12-05T14:10:42ZActuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner2364-550410.1515/cdbme-2020-3090https://doaj.org/article/7f8f0de10ea14a10b11045304ff3a3402020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3090https://doaj.org/toc/2364-5504Magnetic actuation of medical devices is of great interest in improving minimally invasive surgery and enabling targeted drug delivery. With untethered, magnetically coated swimmers it is aimed at reaching regions of the body difficult to access with catheters. Such a swimmer was previously presented, which is suitable for the navigation by the magnetic fields of a magnetic particle imaging (MPI) scanner. The swimmer could be imaged with MPI as well, enabling the tomographic real-time tracking of the actuation process. In this work the steerability of the swimmer is further investigated in media of varying viscosities. For this, glycerol-water-mixtures of different mixing ratios were used. The velocities of the swimmer were measured for viscosities between those of pure glycerol and pure water. The experiments were performed with an MPI scanner at maximal magnetic field strength of the actuating fields. A viscosity range was found in which the swimmer is steerable by the fields of an MPI scanner, which leads to a prediction of the applicability of the swimmer in different body fluids.Bakenecker Anna C.Chinchilla CarlosBuzug Thorsten M.De Gruyterarticlemagnetic actuationmagnetic manipulationmagnetic particle imagingmpimagnetic nanoparticlesmagnetic swimmerMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 349-352 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic actuation magnetic manipulation magnetic particle imaging mpi magnetic nanoparticles magnetic swimmer Medicine R
spellingShingle	magnetic actuation magnetic manipulation magnetic particle imaging mpi magnetic nanoparticles magnetic swimmer Medicine R Bakenecker Anna C. Chinchilla Carlos Buzug Thorsten M. Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner
description	Magnetic actuation of medical devices is of great interest in improving minimally invasive surgery and enabling targeted drug delivery. With untethered, magnetically coated swimmers it is aimed at reaching regions of the body difficult to access with catheters. Such a swimmer was previously presented, which is suitable for the navigation by the magnetic fields of a magnetic particle imaging (MPI) scanner. The swimmer could be imaged with MPI as well, enabling the tomographic real-time tracking of the actuation process. In this work the steerability of the swimmer is further investigated in media of varying viscosities. For this, glycerol-water-mixtures of different mixing ratios were used. The velocities of the swimmer were measured for viscosities between those of pure glycerol and pure water. The experiments were performed with an MPI scanner at maximal magnetic field strength of the actuating fields. A viscosity range was found in which the swimmer is steerable by the fields of an MPI scanner, which leads to a prediction of the applicability of the swimmer in different body fluids.
format	article
author	Bakenecker Anna C. Chinchilla Carlos Buzug Thorsten M.
author_facet	Bakenecker Anna C. Chinchilla Carlos Buzug Thorsten M.
author_sort	Bakenecker Anna C.
title	Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner
title_short	Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner
title_full	Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner
title_fullStr	Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner
title_full_unstemmed	Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner
title_sort	actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/7f8f0de10ea14a10b11045304ff3a340
work_keys_str_mv	AT bakeneckerannac actuationofamagneticallycoatedswimmerinviscousmediawithamagneticparticleimagingscanner AT chinchillacarlos actuationofamagneticallycoatedswimmerinviscousmediawithamagneticparticleimagingscanner AT buzugthorstenm actuationofamagneticallycoatedswimmerinviscousmediawithamagneticparticleimagingscanner
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Actuation of a magnetically coated swimmer in viscous media with a magnetic particle imaging scanner

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