Environmental enrichment modulates cortico-cortical interactions in the mouse.

Environmental enrichment (EE) is an experimental protocol based on a complex sensorimotor stimulation that dramatically affects brain development. While it is widely believed that the effects of EE result from the unique combination of different sensory and motor stimuli, it is not known whether and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Angelo Di Garbo, Marco Mainardi, Santi Chillemi, Lamberto Maffei, Matteo Caleo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f9065bd5c6a41929281224c874a440d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7f9065bd5c6a41929281224c874a440d
record_format	dspace
spelling	oai:doaj.org-article:7f9065bd5c6a41929281224c874a440d2021-11-04T06:07:58ZEnvironmental enrichment modulates cortico-cortical interactions in the mouse.1932-620310.1371/journal.pone.0025285https://doaj.org/article/7f9065bd5c6a41929281224c874a440d2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966482/?tool=EBIhttps://doaj.org/toc/1932-6203Environmental enrichment (EE) is an experimental protocol based on a complex sensorimotor stimulation that dramatically affects brain development. While it is widely believed that the effects of EE result from the unique combination of different sensory and motor stimuli, it is not known whether and how cortico-cortical interactions are shaped by EE. Since the primary visual cortex (V1) is one of the best characterized targets of EE, we looked for direct cortico-cortical projections impinging on V1, and we identified a direct monosynaptic connection between motor cortex and V1 in the mouse brain. To measure the interactions between these areas under standard and EE rearing conditions, we used simultaneous recordings of local field potentials (LFPs) in awake, freely moving animals. LFP signals were analyzed by using different methods of linear and nonlinear analysis of time series (cross-correlation, mutual information, phase synchronization). We found that EE decreases the level of coupling between the electrical activities of the two cortical regions with respect to the control group. From a functional point of view, our results indicate, for the first time, that an enhanced sensorimotor experience impacts on the brain by affecting the functional crosstalk between different cortical areas.Angelo Di GarboMarco MainardiSanti ChillemiLamberto MaffeiMatteo CaleoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e25285 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angelo Di Garbo Marco Mainardi Santi Chillemi Lamberto Maffei Matteo Caleo Environmental enrichment modulates cortico-cortical interactions in the mouse.
description	Environmental enrichment (EE) is an experimental protocol based on a complex sensorimotor stimulation that dramatically affects brain development. While it is widely believed that the effects of EE result from the unique combination of different sensory and motor stimuli, it is not known whether and how cortico-cortical interactions are shaped by EE. Since the primary visual cortex (V1) is one of the best characterized targets of EE, we looked for direct cortico-cortical projections impinging on V1, and we identified a direct monosynaptic connection between motor cortex and V1 in the mouse brain. To measure the interactions between these areas under standard and EE rearing conditions, we used simultaneous recordings of local field potentials (LFPs) in awake, freely moving animals. LFP signals were analyzed by using different methods of linear and nonlinear analysis of time series (cross-correlation, mutual information, phase synchronization). We found that EE decreases the level of coupling between the electrical activities of the two cortical regions with respect to the control group. From a functional point of view, our results indicate, for the first time, that an enhanced sensorimotor experience impacts on the brain by affecting the functional crosstalk between different cortical areas.
format	article
author	Angelo Di Garbo Marco Mainardi Santi Chillemi Lamberto Maffei Matteo Caleo
author_facet	Angelo Di Garbo Marco Mainardi Santi Chillemi Lamberto Maffei Matteo Caleo
author_sort	Angelo Di Garbo
title	Environmental enrichment modulates cortico-cortical interactions in the mouse.
title_short	Environmental enrichment modulates cortico-cortical interactions in the mouse.
title_full	Environmental enrichment modulates cortico-cortical interactions in the mouse.
title_fullStr	Environmental enrichment modulates cortico-cortical interactions in the mouse.
title_full_unstemmed	Environmental enrichment modulates cortico-cortical interactions in the mouse.
title_sort	environmental enrichment modulates cortico-cortical interactions in the mouse.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/7f9065bd5c6a41929281224c874a440d
work_keys_str_mv	AT angelodigarbo environmentalenrichmentmodulatescorticocorticalinteractionsinthemouse AT marcomainardi environmentalenrichmentmodulatescorticocorticalinteractionsinthemouse AT santichillemi environmentalenrichmentmodulatescorticocorticalinteractionsinthemouse AT lambertomaffei environmentalenrichmentmodulatescorticocorticalinteractionsinthemouse AT matteocaleo environmentalenrichmentmodulatescorticocorticalinteractionsinthemouse
_version_	1718445157824593920

Environmental enrichment modulates cortico-cortical interactions in the mouse.

Ejemplares similares