Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Identifying and enumerating tumor-specific CD8 T cells are important for assessing cancer prognosis and therapy efficacy. Here the authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit characteristics of exhausted or tissue-resident memo...

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Autores principales:	Thomas Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, Tarsem Moudgil, Noel F. de Miranda, Cheri P. Goodall, Tiffany C. Blair, Bernard A. Fox, Jason E. McDermott, Shu-Ching Chang, Gary Grunkemeier, Rom Leidner, Richard Bryan Bell, Andrew D. Weinberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f90edfb8d4e4077bb1febd57a7e1381
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spelling	oai:doaj.org-article:7f90edfb8d4e4077bb1febd57a7e13812021-12-02T17:33:01ZCo-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors10.1038/s41467-018-05072-02041-1723https://doaj.org/article/7f90edfb8d4e4077bb1febd57a7e13812018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05072-0https://doaj.org/toc/2041-1723Identifying and enumerating tumor-specific CD8 T cells are important for assessing cancer prognosis and therapy efficacy. Here the authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit characteristics of exhausted or tissue-resident memory T cells.Thomas DuhenRebekka DuhenRyan MontlerJake MosesTarsem MoudgilNoel F. de MirandaCheri P. GoodallTiffany C. BlairBernard A. FoxJason E. McDermottShu-Ching ChangGary GrunkemeierRom LeidnerRichard Bryan BellAndrew D. WeinbergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Duhen Rebekka Duhen Ryan Montler Jake Moses Tarsem Moudgil Noel F. de Miranda Cheri P. Goodall Tiffany C. Blair Bernard A. Fox Jason E. McDermott Shu-Ching Chang Gary Grunkemeier Rom Leidner Richard Bryan Bell Andrew D. Weinberg Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
description	Identifying and enumerating tumor-specific CD8 T cells are important for assessing cancer prognosis and therapy efficacy. Here the authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit characteristics of exhausted or tissue-resident memory T cells.
format	article
author	Thomas Duhen Rebekka Duhen Ryan Montler Jake Moses Tarsem Moudgil Noel F. de Miranda Cheri P. Goodall Tiffany C. Blair Bernard A. Fox Jason E. McDermott Shu-Ching Chang Gary Grunkemeier Rom Leidner Richard Bryan Bell Andrew D. Weinberg
author_facet	Thomas Duhen Rebekka Duhen Ryan Montler Jake Moses Tarsem Moudgil Noel F. de Miranda Cheri P. Goodall Tiffany C. Blair Bernard A. Fox Jason E. McDermott Shu-Ching Chang Gary Grunkemeier Rom Leidner Richard Bryan Bell Andrew D. Weinberg
author_sort	Thomas Duhen
title	Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
title_short	Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
title_full	Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
title_fullStr	Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
title_full_unstemmed	Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
title_sort	co-expression of cd39 and cd103 identifies tumor-reactive cd8 t cells in human solid tumors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7f90edfb8d4e4077bb1febd57a7e1381
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Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

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