Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.

<h4>Objective</h4>To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA).<h4>Methods</h4>Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects w...

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Autores principales:	Kee Sup Park, Hyung Bin Lim, Yong Il Shin, Gi Seok Park, Woo Hyuk Lee, Jung-Yeul Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f91dd48c53f479c8e136ada7189d1fc
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spelling	oai:doaj.org-article:7f91dd48c53f479c8e136ada7189d1fc2021-12-02T20:19:14ZEffect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.1932-620310.1371/journal.pone.0258479https://doaj.org/article/7f91dd48c53f479c8e136ada7189d1fc2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258479https://doaj.org/toc/1932-6203<h4>Objective</h4>To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA).<h4>Methods</h4>Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: < 24.0 mm; 35 eyes), Group 2 (AL: 24.0-25.99 mm; 37 eyes), and Group 3 (AL: ≥ 26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6× 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated automatically. VD and PD were compared among the three groups according to the distance from the optic disc (inner and outer rings). Linear regression analyses were also performed to identify clinical factors associated with average VD.<h4>Results</h4>The average ALs of Groups 1-3 were 23.33± 0.57, 25.05± 0.60, and 27.42± 0.82, respectively. Average VD (P = 0.009) and PD (P = 0.029) in the inner ring increased with increasing AL. However, average VD (P < 0.001) and PD (P < 0.001) in the outer ring decreased with AL increased; the same trends were found for the full areas (VD, p<0.001; PD, p = 0.001). Average VDs in the inner and outer rings were not associated (P = 0.938).<h4>Conclusions</h4>Peripapillary VD and PD were significantly associated with AL. Depending on the distance from the disc, peripapillary VDs and PDs of the inner and outer rings were differentially affected by AL. Physicians should therefore consider the effects of AL in the analyses of peripapillary microvasculature.Kee Sup ParkHyung Bin LimYong Il ShinGi Seok ParkWoo Hyuk LeeJung-Yeul KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258479 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kee Sup Park Hyung Bin Lim Yong Il Shin Gi Seok Park Woo Hyuk Lee Jung-Yeul Kim Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.
description	<h4>Objective</h4>To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA).<h4>Methods</h4>Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: < 24.0 mm; 35 eyes), Group 2 (AL: 24.0-25.99 mm; 37 eyes), and Group 3 (AL: ≥ 26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6× 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated automatically. VD and PD were compared among the three groups according to the distance from the optic disc (inner and outer rings). Linear regression analyses were also performed to identify clinical factors associated with average VD.<h4>Results</h4>The average ALs of Groups 1-3 were 23.33± 0.57, 25.05± 0.60, and 27.42± 0.82, respectively. Average VD (P = 0.009) and PD (P = 0.029) in the inner ring increased with increasing AL. However, average VD (P < 0.001) and PD (P < 0.001) in the outer ring decreased with AL increased; the same trends were found for the full areas (VD, p<0.001; PD, p = 0.001). Average VDs in the inner and outer rings were not associated (P = 0.938).<h4>Conclusions</h4>Peripapillary VD and PD were significantly associated with AL. Depending on the distance from the disc, peripapillary VDs and PDs of the inner and outer rings were differentially affected by AL. Physicians should therefore consider the effects of AL in the analyses of peripapillary microvasculature.
format	article
author	Kee Sup Park Hyung Bin Lim Yong Il Shin Gi Seok Park Woo Hyuk Lee Jung-Yeul Kim
author_facet	Kee Sup Park Hyung Bin Lim Yong Il Shin Gi Seok Park Woo Hyuk Lee Jung-Yeul Kim
author_sort	Kee Sup Park
title	Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.
title_short	Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.
title_full	Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.
title_fullStr	Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.
title_full_unstemmed	Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.
title_sort	effect of axial length on peripapillary microvasculature: an optical coherence tomography angiography study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7f91dd48c53f479c8e136ada7189d1fc
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Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.

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