Orchestrated efforts on host network hijacking: Processes governing virus replication

With the high pervasiveness of viral diseases, the battle against viruses has never ceased. Here we discuss five cellular processes, namely “autophagy”, “programmed cell death”, “immune response”, “cell cycle alteration”, and “lipid metabolic reprogramming”, that considerably guide viral replication...

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Autores principales:	Xiaofeng Dai, Olivier Hakizimana, Xuanhao Zhang, Aman Chandra Kaushik, Jianying Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	virus replication autophagy programmed cell death immune response cell cycle alteration lipid metabolic reprogramming Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/7f92403d6b56459ca7a41ec1a641bc6a
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spelling	oai:doaj.org-article:7f92403d6b56459ca7a41ec1a641bc6a2021-11-17T14:21:58ZOrchestrated efforts on host network hijacking: Processes governing virus replication2150-55942150-560810.1080/21505594.2020.1726594https://doaj.org/article/7f92403d6b56459ca7a41ec1a641bc6a2020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1726594https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608With the high pervasiveness of viral diseases, the battle against viruses has never ceased. Here we discuss five cellular processes, namely “autophagy”, “programmed cell death”, “immune response”, “cell cycle alteration”, and “lipid metabolic reprogramming”, that considerably guide viral replication after host infection in an orchestrated manner. On viral infection, “autophagy” and “programmed cell death” are two dynamically synchronized cell survival programs; “immune response” is a cell defense program typically suppressed by viruses; “cell cycle alteration” and “lipid metabolic reprogramming” are two altered cell housekeeping programs tunable in both directions. We emphasize on their functionalities in modulating viral replication, strategies viruses have evolved to tune these processes for their benefit, and how these processes orchestrate and govern cell fate upon viral infection. Understanding how viruses hijack host networks has both academic and industrial values in providing insights toward therapeutic strategy design for viral disease control, offering useful information in applications that aim to use viral vectors to improve human health such as gene therapy, and providing guidelines to maximize viral particle yield for improved vaccine production at a reduced cost.Xiaofeng DaiOlivier HakizimanaXuanhao ZhangAman Chandra KaushikJianying ZhangTaylor & Francis Grouparticlevirus replicationautophagyprogrammed cell deathimmune responsecell cycle alterationlipid metabolic reprogrammingInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 183-198 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	virus replication autophagy programmed cell death immune response cell cycle alteration lipid metabolic reprogramming Infectious and parasitic diseases RC109-216
spellingShingle	virus replication autophagy programmed cell death immune response cell cycle alteration lipid metabolic reprogramming Infectious and parasitic diseases RC109-216 Xiaofeng Dai Olivier Hakizimana Xuanhao Zhang Aman Chandra Kaushik Jianying Zhang Orchestrated efforts on host network hijacking: Processes governing virus replication
description	With the high pervasiveness of viral diseases, the battle against viruses has never ceased. Here we discuss five cellular processes, namely “autophagy”, “programmed cell death”, “immune response”, “cell cycle alteration”, and “lipid metabolic reprogramming”, that considerably guide viral replication after host infection in an orchestrated manner. On viral infection, “autophagy” and “programmed cell death” are two dynamically synchronized cell survival programs; “immune response” is a cell defense program typically suppressed by viruses; “cell cycle alteration” and “lipid metabolic reprogramming” are two altered cell housekeeping programs tunable in both directions. We emphasize on their functionalities in modulating viral replication, strategies viruses have evolved to tune these processes for their benefit, and how these processes orchestrate and govern cell fate upon viral infection. Understanding how viruses hijack host networks has both academic and industrial values in providing insights toward therapeutic strategy design for viral disease control, offering useful information in applications that aim to use viral vectors to improve human health such as gene therapy, and providing guidelines to maximize viral particle yield for improved vaccine production at a reduced cost.
format	article
author	Xiaofeng Dai Olivier Hakizimana Xuanhao Zhang Aman Chandra Kaushik Jianying Zhang
author_facet	Xiaofeng Dai Olivier Hakizimana Xuanhao Zhang Aman Chandra Kaushik Jianying Zhang
author_sort	Xiaofeng Dai
title	Orchestrated efforts on host network hijacking: Processes governing virus replication
title_short	Orchestrated efforts on host network hijacking: Processes governing virus replication
title_full	Orchestrated efforts on host network hijacking: Processes governing virus replication
title_fullStr	Orchestrated efforts on host network hijacking: Processes governing virus replication
title_full_unstemmed	Orchestrated efforts on host network hijacking: Processes governing virus replication
title_sort	orchestrated efforts on host network hijacking: processes governing virus replication
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/7f92403d6b56459ca7a41ec1a641bc6a
work_keys_str_mv	AT xiaofengdai orchestratedeffortsonhostnetworkhijackingprocessesgoverningvirusreplication AT olivierhakizimana orchestratedeffortsonhostnetworkhijackingprocessesgoverningvirusreplication AT xuanhaozhang orchestratedeffortsonhostnetworkhijackingprocessesgoverningvirusreplication AT amanchandrakaushik orchestratedeffortsonhostnetworkhijackingprocessesgoverningvirusreplication AT jianyingzhang orchestratedeffortsonhostnetworkhijackingprocessesgoverningvirusreplication
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Orchestrated efforts on host network hijacking: Processes governing virus replication

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