Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases

Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease recurrence is common and the available preoperative stratification strategies are often imprecise to identify the ideal candidates for surgical tre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sven H. Loosen, Christoph Roderburg, Patrick H. Alizai, Anjali A. Roeth, Sophia M. Schmitz, Mihael Vucur, Mark Luedde, David Schöler, Pia Paffenholz, Frank Tacke, Christian Trautwein, Tom Luedde, Ulf P. Neumann, Tom F. Ulmer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CRLM CRC cancer liver resection CEA CA19-9 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7f92f981670b4cadb7eb16bf1ca2c6a8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7f92f981670b4cadb7eb16bf1ca2c6a8
record_format	dspace
spelling	oai:doaj.org-article:7f92f981670b4cadb7eb16bf1ca2c6a82021-11-25T17:20:37ZComparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases10.3390/diagnostics111119992075-4418https://doaj.org/article/7f92f981670b4cadb7eb16bf1ca2c6a82021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1999https://doaj.org/toc/2075-4418Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease recurrence is common and the available preoperative stratification strategies are often imprecise to identify the ideal candidates for surgical treatment, resulting in a postoperative 5-year survival rate below 50%. Data on the prognostic value of CEA, CA19-9 and other common laboratory parameters after CRLM resection are scarce and partly inconclusive. Here, we analyzed the prognostic potential of circulating CEA and CA19-9 in comparison to other standard laboratory markers in resectable CRLM patients. Serum levels of tumor markers and other laboratory parameters were analyzed in 125 patients with CRLM undergoing tumor resection at a tertiary referral center. Results were correlated with clinical data and outcome. Both tumor markers were significantly elevated in CRLM patients compared to healthy controls. Interestingly, elevated levels of CEA, CA19-9 and C-reactive protein (CRP) were associated with an unfavorable prognosis after CRLM resection in Kaplan–Meier curve analysis. However, only CEA and not CA19-9 or CRP serum levels were an independent prognostic marker in multivariate Cox regression analysis. Our data demonstrate that circulating levels of CEA rather than CA19-9 might be a valuable addition to the existing preoperative stratification algorithms to identify patients with a poor prognosis after CRLM resection.Sven H. LoosenChristoph RoderburgPatrick H. AlizaiAnjali A. RoethSophia M. SchmitzMihael VucurMark LueddeDavid SchölerPia PaffenholzFrank TackeChristian TrautweinTom LueddeUlf P. NeumannTom F. UlmerMDPI AGarticleCRLMCRCcancerliver resectionCEACA19-9Medicine (General)R5-920ENDiagnostics, Vol 11, Iss 1999, p 1999 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CRLM CRC cancer liver resection CEA CA19-9 Medicine (General) R5-920
spellingShingle	CRLM CRC cancer liver resection CEA CA19-9 Medicine (General) R5-920 Sven H. Loosen Christoph Roderburg Patrick H. Alizai Anjali A. Roeth Sophia M. Schmitz Mihael Vucur Mark Luedde David Schöler Pia Paffenholz Frank Tacke Christian Trautwein Tom Luedde Ulf P. Neumann Tom F. Ulmer Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases
description	Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease recurrence is common and the available preoperative stratification strategies are often imprecise to identify the ideal candidates for surgical treatment, resulting in a postoperative 5-year survival rate below 50%. Data on the prognostic value of CEA, CA19-9 and other common laboratory parameters after CRLM resection are scarce and partly inconclusive. Here, we analyzed the prognostic potential of circulating CEA and CA19-9 in comparison to other standard laboratory markers in resectable CRLM patients. Serum levels of tumor markers and other laboratory parameters were analyzed in 125 patients with CRLM undergoing tumor resection at a tertiary referral center. Results were correlated with clinical data and outcome. Both tumor markers were significantly elevated in CRLM patients compared to healthy controls. Interestingly, elevated levels of CEA, CA19-9 and C-reactive protein (CRP) were associated with an unfavorable prognosis after CRLM resection in Kaplan–Meier curve analysis. However, only CEA and not CA19-9 or CRP serum levels were an independent prognostic marker in multivariate Cox regression analysis. Our data demonstrate that circulating levels of CEA rather than CA19-9 might be a valuable addition to the existing preoperative stratification algorithms to identify patients with a poor prognosis after CRLM resection.
format	article
author	Sven H. Loosen Christoph Roderburg Patrick H. Alizai Anjali A. Roeth Sophia M. Schmitz Mihael Vucur Mark Luedde David Schöler Pia Paffenholz Frank Tacke Christian Trautwein Tom Luedde Ulf P. Neumann Tom F. Ulmer
author_facet	Sven H. Loosen Christoph Roderburg Patrick H. Alizai Anjali A. Roeth Sophia M. Schmitz Mihael Vucur Mark Luedde David Schöler Pia Paffenholz Frank Tacke Christian Trautwein Tom Luedde Ulf P. Neumann Tom F. Ulmer
author_sort	Sven H. Loosen
title	Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases
title_short	Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases
title_full	Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases
title_fullStr	Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases
title_full_unstemmed	Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases
title_sort	comparative analysis of circulating biomarkers for patients undergoing resection of colorectal liver metastases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f92f981670b4cadb7eb16bf1ca2c6a8
work_keys_str_mv	AT svenhloosen comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT christophroderburg comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT patrickhalizai comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT anjaliaroeth comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT sophiamschmitz comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT mihaelvucur comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT markluedde comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT davidscholer comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT piapaffenholz comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT franktacke comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT christiantrautwein comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT tomluedde comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT ulfpneumann comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases AT tomfulmer comparativeanalysisofcirculatingbiomarkersforpatientsundergoingresectionofcolorectallivermetastases
_version_	1718412480516980736

Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases

Ejemplares similares