Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

The treatment of skin wounds poses significant clinical challenges, including the risk of bacterial infection. In particular due to its antimicrobial and tissue regeneration abilities chitosan (a polymeric biomaterial obtained by the deacetylation of chitin) has received extensive attention for its...

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Autores principales:	Laura Lozano Chamizo, Yurena Luengo Morato, Karina Ovejero Paredes, Rafael Contreras Caceres, Marco Filice, Marzia Marciello
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chitosan gold silver iron oxide nanoparticles biomedical applications Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/7f955d1e984e415f8164d6dae0fad4fc
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spelling	oai:doaj.org-article:7f955d1e984e415f8164d6dae0fad4fc2021-11-25T18:48:12ZIonotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities10.3390/polym132239102073-4360https://doaj.org/article/7f955d1e984e415f8164d6dae0fad4fc2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3910https://doaj.org/toc/2073-4360The treatment of skin wounds poses significant clinical challenges, including the risk of bacterial infection. In particular due to its antimicrobial and tissue regeneration abilities chitosan (a polymeric biomaterial obtained by the deacetylation of chitin) has received extensive attention for its effectiveness in promoting skin wound repair. On the other hand, due to their intrinsic characteristics, metal nanoparticles (e.g., silver (Ag), gold (Au) or iron oxide (Fe<sub>3</sub>O<sub>4</sub>)) have demonstrated therapeutic properties potentially useful in the field of skin care. Therefore, the combination of these two promising materials (chitosan plus metal oxide NPs) could permit the achievement of a promising nanohybrid with enhanced properties that could be applied in advanced skin treatment. In this work, we have optimized the synthesis protocol of chitosan/metal hybrid nanoparticles by means of a straightforward synthetic method, ionotropic gelation, which presents a wide set of advantages. The synthesized hybrid NPs have undergone to a full physicochemical characterization. After that, the in vitro antibacterial and tissue regenerative activities of the achieved hybrids have been assessed in comparison to their individual constituent. As result, we have demonstrated the synergistic antibacterial plus the tissue regeneration enhancement of these nanohybrids as a consequence of the fusion between chitosan and metallic nanoparticles, especially in the case of chitosan/Fe<sub>3</sub>O<sub>4</sub> hybrid nanoparticles.Laura Lozano ChamizoYurena Luengo MoratoKarina Ovejero ParedesRafael Contreras CaceresMarco FiliceMarzia MarcielloMDPI AGarticlechitosangoldsilveriron oxidenanoparticlesbiomedical applicationsOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3910, p 3910 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan gold silver iron oxide nanoparticles biomedical applications Organic chemistry QD241-441
spellingShingle	chitosan gold silver iron oxide nanoparticles biomedical applications Organic chemistry QD241-441 Laura Lozano Chamizo Yurena Luengo Morato Karina Ovejero Paredes Rafael Contreras Caceres Marco Filice Marzia Marciello Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities
description	The treatment of skin wounds poses significant clinical challenges, including the risk of bacterial infection. In particular due to its antimicrobial and tissue regeneration abilities chitosan (a polymeric biomaterial obtained by the deacetylation of chitin) has received extensive attention for its effectiveness in promoting skin wound repair. On the other hand, due to their intrinsic characteristics, metal nanoparticles (e.g., silver (Ag), gold (Au) or iron oxide (Fe<sub>3</sub>O<sub>4</sub>)) have demonstrated therapeutic properties potentially useful in the field of skin care. Therefore, the combination of these two promising materials (chitosan plus metal oxide NPs) could permit the achievement of a promising nanohybrid with enhanced properties that could be applied in advanced skin treatment. In this work, we have optimized the synthesis protocol of chitosan/metal hybrid nanoparticles by means of a straightforward synthetic method, ionotropic gelation, which presents a wide set of advantages. The synthesized hybrid NPs have undergone to a full physicochemical characterization. After that, the in vitro antibacterial and tissue regenerative activities of the achieved hybrids have been assessed in comparison to their individual constituent. As result, we have demonstrated the synergistic antibacterial plus the tissue regeneration enhancement of these nanohybrids as a consequence of the fusion between chitosan and metallic nanoparticles, especially in the case of chitosan/Fe<sub>3</sub>O<sub>4</sub> hybrid nanoparticles.
format	article
author	Laura Lozano Chamizo Yurena Luengo Morato Karina Ovejero Paredes Rafael Contreras Caceres Marco Filice Marzia Marciello
author_facet	Laura Lozano Chamizo Yurena Luengo Morato Karina Ovejero Paredes Rafael Contreras Caceres Marco Filice Marzia Marciello
author_sort	Laura Lozano Chamizo
title	Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities
title_short	Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities
title_full	Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities
title_fullStr	Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities
title_full_unstemmed	Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities
title_sort	ionotropic gelation-based synthesis of chitosan-metal hybrid nanoparticles showing combined antimicrobial and tissue regenerative activities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f955d1e984e415f8164d6dae0fad4fc
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Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

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