Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD.
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Nature Portfolio
2019
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oai:doaj.org-article:7f973dabdbee4e05bfa82fda5c334da72021-12-02T14:39:59ZInvolvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis10.1038/s41467-019-10991-72041-1723https://doaj.org/article/7f973dabdbee4e05bfa82fda5c334da72019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10991-7https://doaj.org/toc/2041-1723Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD.Masahiro YoshidaShunsuke MinagawaJun ArayaTaro SakamotoHiromichi HaraKazuya TsubouchiYusuke HosakaAkihiro IchikawaNayuta SaitoTsukasa KadotaNahoko SatoYusuke KuritaKenji KobayashiSaburo ItoHirohumi UtsumiHiroshi WakuiTakanori NumataYumi KanekoShohei MoriHisatoshi AsanoMakoto YamashitaMakoto OdakaToshiaki MorikawaKatsutoshi NakayamaTakeo IwamotoHirotaka ImaiKazuyoshi KuwanoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Masahiro Yoshida Shunsuke Minagawa Jun Araya Taro Sakamoto Hiromichi Hara Kazuya Tsubouchi Yusuke Hosaka Akihiro Ichikawa Nayuta Saito Tsukasa Kadota Nahoko Sato Yusuke Kurita Kenji Kobayashi Saburo Ito Hirohumi Utsumi Hiroshi Wakui Takanori Numata Yumi Kaneko Shohei Mori Hisatoshi Asano Makoto Yamashita Makoto Odaka Toshiaki Morikawa Katsutoshi Nakayama Takeo Iwamoto Hirotaka Imai Kazuyoshi Kuwano Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| description |
Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD. |
| format |
article |
| author |
Masahiro Yoshida Shunsuke Minagawa Jun Araya Taro Sakamoto Hiromichi Hara Kazuya Tsubouchi Yusuke Hosaka Akihiro Ichikawa Nayuta Saito Tsukasa Kadota Nahoko Sato Yusuke Kurita Kenji Kobayashi Saburo Ito Hirohumi Utsumi Hiroshi Wakui Takanori Numata Yumi Kaneko Shohei Mori Hisatoshi Asano Makoto Yamashita Makoto Odaka Toshiaki Morikawa Katsutoshi Nakayama Takeo Iwamoto Hirotaka Imai Kazuyoshi Kuwano |
| author_facet |
Masahiro Yoshida Shunsuke Minagawa Jun Araya Taro Sakamoto Hiromichi Hara Kazuya Tsubouchi Yusuke Hosaka Akihiro Ichikawa Nayuta Saito Tsukasa Kadota Nahoko Sato Yusuke Kurita Kenji Kobayashi Saburo Ito Hirohumi Utsumi Hiroshi Wakui Takanori Numata Yumi Kaneko Shohei Mori Hisatoshi Asano Makoto Yamashita Makoto Odaka Toshiaki Morikawa Katsutoshi Nakayama Takeo Iwamoto Hirotaka Imai Kazuyoshi Kuwano |
| author_sort |
Masahiro Yoshida |
| title |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_short |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_full |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_fullStr |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_full_unstemmed |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_sort |
involvement of cigarette smoke-induced epithelial cell ferroptosis in copd pathogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7f973dabdbee4e05bfa82fda5c334da7 |
| work_keys_str_mv |
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| _version_ |
1718390425597771776 |