Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

Understanding how transplanted cells interact with the host nervous system will be important for cell based neural regeneration approaches. Here, the authors study the sensory fate of neural progenitor cell grafts transplanted to the injured spinal cord, and show that host axons retain the ability t...

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Autores principales:	Jennifer N. Dulin, Andrew F. Adler, Hiromi Kumamaru, Gunnar H. D. Poplawski, Corinne Lee-Kubli, Hans Strobl, Daniel Gibbs, Ken Kadoya, James W. Fawcett, Paul Lu, Mark H. Tuszynski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f9b4eafb46245958438aafcbd21521f
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spelling	oai:doaj.org-article:7f9b4eafb46245958438aafcbd21521f2021-12-02T17:31:43ZInjured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts10.1038/s41467-017-02613-x2041-1723https://doaj.org/article/7f9b4eafb46245958438aafcbd21521f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02613-xhttps://doaj.org/toc/2041-1723Understanding how transplanted cells interact with the host nervous system will be important for cell based neural regeneration approaches. Here, the authors study the sensory fate of neural progenitor cell grafts transplanted to the injured spinal cord, and show that host axons retain the ability to distinguish appropriate and inappropriate graft targets.Jennifer N. DulinAndrew F. AdlerHiromi KumamaruGunnar H. D. PoplawskiCorinne Lee-KubliHans StroblDaniel GibbsKen KadoyaJames W. FawcettPaul LuMark H. TuszynskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer N. Dulin Andrew F. Adler Hiromi Kumamaru Gunnar H. D. Poplawski Corinne Lee-Kubli Hans Strobl Daniel Gibbs Ken Kadoya James W. Fawcett Paul Lu Mark H. Tuszynski Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
description	Understanding how transplanted cells interact with the host nervous system will be important for cell based neural regeneration approaches. Here, the authors study the sensory fate of neural progenitor cell grafts transplanted to the injured spinal cord, and show that host axons retain the ability to distinguish appropriate and inappropriate graft targets.
format	article
author	Jennifer N. Dulin Andrew F. Adler Hiromi Kumamaru Gunnar H. D. Poplawski Corinne Lee-Kubli Hans Strobl Daniel Gibbs Ken Kadoya James W. Fawcett Paul Lu Mark H. Tuszynski
author_facet	Jennifer N. Dulin Andrew F. Adler Hiromi Kumamaru Gunnar H. D. Poplawski Corinne Lee-Kubli Hans Strobl Daniel Gibbs Ken Kadoya James W. Fawcett Paul Lu Mark H. Tuszynski
author_sort	Jennifer N. Dulin
title	Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
title_short	Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
title_full	Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
title_fullStr	Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
title_full_unstemmed	Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
title_sort	injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7f9b4eafb46245958438aafcbd21521f
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Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

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