Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis

BackgroundCystatin C (CysC) is often used to diagnose and monitor renal diseases. Although some studies have investigated the association between serum CysC levels and thyroid diseases, their reported results were inconsistent. Therefore, the relationship between CysC levels and thyroid diseases rem...

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Autores principales:	Caihong Xin, Jing Xie, Huaying Fan, Xin Sun, Bimin Shi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cystatin C CysC thyroid disease systematic review meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/7f9ba0aa3fa04dd68584268a751c90be
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spelling	oai:doaj.org-article:7f9ba0aa3fa04dd68584268a751c90be2021-11-19T05:24:09ZAssociation Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis1664-239210.3389/fendo.2021.766516https://doaj.org/article/7f9ba0aa3fa04dd68584268a751c90be2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.766516/fullhttps://doaj.org/toc/1664-2392BackgroundCystatin C (CysC) is often used to diagnose and monitor renal diseases. Although some studies have investigated the association between serum CysC levels and thyroid diseases, their reported results were inconsistent. Therefore, the relationship between CysC levels and thyroid diseases remains controversial.AimThis meta-analysis aimed to statistically evaluate serum CysC levels in patients with thyroid diseases.MethodsA literature search was conducted using the PubMed, Web of Science, Embase, EBSCO, and Wiley Online Library databases. The following search terms were used for the title or abstract: “Cystatin C” or “CysC” in combination with the terms “thyroid disease”, “thyroid function”, “hypothyroidism”, or “hyperthyroidism”. The results of the systematic analysis were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).ResultsEleven articles (1,265 cases and 894 controls) were included in the meta-analysis. The results of the meta-analysis showed that the serum CysC levels of patients with hyperthyroidism were significantly higher than those of the controls (SMD: 1.79, 95% CI [1.34, 2.25]), and the serum CysC levels of patients with hypothyroidism were significantly lower than those of the controls (SMD −0.59, 95% CI [−0.82, −0.36]). Moreover, the treatment of thyroid diseases significantly affected serum CysC levels.ConclusionsTo the best of our knowledge, this meta-analysis is the first to evaluate serum CysC levels in patients with thyroid diseases. Our findings suggest that thyroid function affects serum CysC levels and that serum CysC may be an effective marker for monitoring thyroid diseases.Systematic Review RegistrationPROSPERO [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=258022], identifier CRD42021258022].Caihong XinJing XieHuaying FanXin SunBimin ShiFrontiers Media S.A.articlecystatin CCysCthyroid diseasesystematic reviewmeta-analysisDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystatin C CysC thyroid disease systematic review meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	cystatin C CysC thyroid disease systematic review meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Caihong Xin Jing Xie Huaying Fan Xin Sun Bimin Shi Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis
description	BackgroundCystatin C (CysC) is often used to diagnose and monitor renal diseases. Although some studies have investigated the association between serum CysC levels and thyroid diseases, their reported results were inconsistent. Therefore, the relationship between CysC levels and thyroid diseases remains controversial.AimThis meta-analysis aimed to statistically evaluate serum CysC levels in patients with thyroid diseases.MethodsA literature search was conducted using the PubMed, Web of Science, Embase, EBSCO, and Wiley Online Library databases. The following search terms were used for the title or abstract: “Cystatin C” or “CysC” in combination with the terms “thyroid disease”, “thyroid function”, “hypothyroidism”, or “hyperthyroidism”. The results of the systematic analysis were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).ResultsEleven articles (1,265 cases and 894 controls) were included in the meta-analysis. The results of the meta-analysis showed that the serum CysC levels of patients with hyperthyroidism were significantly higher than those of the controls (SMD: 1.79, 95% CI [1.34, 2.25]), and the serum CysC levels of patients with hypothyroidism were significantly lower than those of the controls (SMD −0.59, 95% CI [−0.82, −0.36]). Moreover, the treatment of thyroid diseases significantly affected serum CysC levels.ConclusionsTo the best of our knowledge, this meta-analysis is the first to evaluate serum CysC levels in patients with thyroid diseases. Our findings suggest that thyroid function affects serum CysC levels and that serum CysC may be an effective marker for monitoring thyroid diseases.Systematic Review RegistrationPROSPERO [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=258022], identifier CRD42021258022].
format	article
author	Caihong Xin Jing Xie Huaying Fan Xin Sun Bimin Shi
author_facet	Caihong Xin Jing Xie Huaying Fan Xin Sun Bimin Shi
author_sort	Caihong Xin
title	Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis
title_short	Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis
title_full	Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis
title_fullStr	Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis
title_full_unstemmed	Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis
title_sort	association between serum cystatin c and thyroid diseases: a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7f9ba0aa3fa04dd68584268a751c90be
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Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis

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