A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens

Preparation of xanthene-containing compounds has been limited due to structural bias existing methods pose. Here, the authors developed a mild, diversity-oriented method for rhodamines synthesis, leading to the finding of compounds with antibacterial potency against a variety of bacterial species.

Guardado en:
Detalles Bibliográficos
Autores principales: Xiao Luo, Liujia Qian, Yansheng Xiao, Yao Tang, Yang Zhao, Xia Wang, Luyan Gu, Zuhai Lei, Jianming Bao, Jiahui Wu, Tingting He, Fupin Hu, Jing Zheng, Honglin Li, Weiping Zhu, Lei Shao, Xiaojing Dong, Daijie Chen, Xuhong Qian, Youjun Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/7f9e3e4ad4f24fdba7bc585c570c4c6f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:7f9e3e4ad4f24fdba7bc585c570c4c6f
record_format dspace
spelling oai:doaj.org-article:7f9e3e4ad4f24fdba7bc585c570c4c6f2021-12-02T17:02:02ZA diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens10.1038/s41467-018-08241-32041-1723https://doaj.org/article/7f9e3e4ad4f24fdba7bc585c570c4c6f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08241-3https://doaj.org/toc/2041-1723Preparation of xanthene-containing compounds has been limited due to structural bias existing methods pose. Here, the authors developed a mild, diversity-oriented method for rhodamines synthesis, leading to the finding of compounds with antibacterial potency against a variety of bacterial species.Xiao LuoLiujia QianYansheng XiaoYao TangYang ZhaoXia WangLuyan GuZuhai LeiJianming BaoJiahui WuTingting HeFupin HuJing ZhengHonglin LiWeiping ZhuLei ShaoXiaojing DongDaijie ChenXuhong QianYoujun YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiao Luo
Liujia Qian
Yansheng Xiao
Yao Tang
Yang Zhao
Xia Wang
Luyan Gu
Zuhai Lei
Jianming Bao
Jiahui Wu
Tingting He
Fupin Hu
Jing Zheng
Honglin Li
Weiping Zhu
Lei Shao
Xiaojing Dong
Daijie Chen
Xuhong Qian
Youjun Yang
A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
description Preparation of xanthene-containing compounds has been limited due to structural bias existing methods pose. Here, the authors developed a mild, diversity-oriented method for rhodamines synthesis, leading to the finding of compounds with antibacterial potency against a variety of bacterial species.
format article
author Xiao Luo
Liujia Qian
Yansheng Xiao
Yao Tang
Yang Zhao
Xia Wang
Luyan Gu
Zuhai Lei
Jianming Bao
Jiahui Wu
Tingting He
Fupin Hu
Jing Zheng
Honglin Li
Weiping Zhu
Lei Shao
Xiaojing Dong
Daijie Chen
Xuhong Qian
Youjun Yang
author_facet Xiao Luo
Liujia Qian
Yansheng Xiao
Yao Tang
Yang Zhao
Xia Wang
Luyan Gu
Zuhai Lei
Jianming Bao
Jiahui Wu
Tingting He
Fupin Hu
Jing Zheng
Honglin Li
Weiping Zhu
Lei Shao
Xiaojing Dong
Daijie Chen
Xuhong Qian
Youjun Yang
author_sort Xiao Luo
title A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
title_short A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
title_full A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
title_fullStr A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
title_full_unstemmed A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
title_sort diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/7f9e3e4ad4f24fdba7bc585c570c4c6f
work_keys_str_mv AT xiaoluo adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT liujiaqian adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT yanshengxiao adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT yaotang adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT yangzhao adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT xiawang adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT luyangu adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT zuhailei adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT jianmingbao adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT jiahuiwu adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT tingtinghe adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT fupinhu adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT jingzheng adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT honglinli adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT weipingzhu adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT leishao adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT xiaojingdong adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT daijiechen adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT xuhongqian adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT youjunyang adiversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT xiaoluo diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT liujiaqian diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT yanshengxiao diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT yaotang diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT yangzhao diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT xiawang diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT luyangu diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT zuhailei diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT jianmingbao diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT jiahuiwu diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT tingtinghe diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT fupinhu diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT jingzheng diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT honglinli diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT weipingzhu diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT leishao diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT xiaojingdong diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT daijiechen diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT xuhongqian diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
AT youjunyang diversityorientedrhodaminelibraryforwidespectrumbactericidalagentswithlowinducibleresistanceagainstresistantpathogens
_version_ 1718381978739277824