STING enhances cell death through regulation of reactive oxygen species and DNA damage

The endoplasmic reticulum-localized adaptor STING regulates the innate immune response through its ability to sense DNA damage. Here the authors reveal that STING functions as a regulator of cellular ROS homeostasis and tumor cell susceptibility to reactive oxygen dependent, DNA damaging agents.

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Detalles Bibliográficos
Autores principales:	Thomas J. Hayman, Marta Baro, Tyler MacNeil, Chatchai Phoomak, Thazin Nwe Aung, Wei Cui, Kevin Leach, Radhakrishnan Iyer, Sreerupa Challa, Teresa Sandoval-Schaefer, Barbara A. Burtness, David L. Rimm, Joseph N. Contessa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f9f99967a354a5b93d3fe5db608fc2d
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spelling	oai:doaj.org-article:7f9f99967a354a5b93d3fe5db608fc2d2021-12-02T18:28:38ZSTING enhances cell death through regulation of reactive oxygen species and DNA damage10.1038/s41467-021-22572-82041-1723https://doaj.org/article/7f9f99967a354a5b93d3fe5db608fc2d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22572-8https://doaj.org/toc/2041-1723The endoplasmic reticulum-localized adaptor STING regulates the innate immune response through its ability to sense DNA damage. Here the authors reveal that STING functions as a regulator of cellular ROS homeostasis and tumor cell susceptibility to reactive oxygen dependent, DNA damaging agents.Thomas J. HaymanMarta BaroTyler MacNeilChatchai PhoomakThazin Nwe AungWei CuiKevin LeachRadhakrishnan IyerSreerupa ChallaTeresa Sandoval-SchaeferBarbara A. BurtnessDavid L. RimmJoseph N. ContessaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas J. Hayman Marta Baro Tyler MacNeil Chatchai Phoomak Thazin Nwe Aung Wei Cui Kevin Leach Radhakrishnan Iyer Sreerupa Challa Teresa Sandoval-Schaefer Barbara A. Burtness David L. Rimm Joseph N. Contessa STING enhances cell death through regulation of reactive oxygen species and DNA damage
description	The endoplasmic reticulum-localized adaptor STING regulates the innate immune response through its ability to sense DNA damage. Here the authors reveal that STING functions as a regulator of cellular ROS homeostasis and tumor cell susceptibility to reactive oxygen dependent, DNA damaging agents.
format	article
author	Thomas J. Hayman Marta Baro Tyler MacNeil Chatchai Phoomak Thazin Nwe Aung Wei Cui Kevin Leach Radhakrishnan Iyer Sreerupa Challa Teresa Sandoval-Schaefer Barbara A. Burtness David L. Rimm Joseph N. Contessa
author_facet	Thomas J. Hayman Marta Baro Tyler MacNeil Chatchai Phoomak Thazin Nwe Aung Wei Cui Kevin Leach Radhakrishnan Iyer Sreerupa Challa Teresa Sandoval-Schaefer Barbara A. Burtness David L. Rimm Joseph N. Contessa
author_sort	Thomas J. Hayman
title	STING enhances cell death through regulation of reactive oxygen species and DNA damage
title_short	STING enhances cell death through regulation of reactive oxygen species and DNA damage
title_full	STING enhances cell death through regulation of reactive oxygen species and DNA damage
title_fullStr	STING enhances cell death through regulation of reactive oxygen species and DNA damage
title_full_unstemmed	STING enhances cell death through regulation of reactive oxygen species and DNA damage
title_sort	sting enhances cell death through regulation of reactive oxygen species and dna damage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f9f99967a354a5b93d3fe5db608fc2d
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STING enhances cell death through regulation of reactive oxygen species and DNA damage

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