Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats

This study was carried out on 30 mature male albino rats (2 months old, weighed about 130 g) in 3 groups of ten rats for each one in ARC. Group I, kept as control. Group II, daily intubated with CPF, at a dose level of 10.6 mg/kg BW in corn oil. Group III, daily intubated with CPF at a dose level of...

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Autores principales:	Assi, M.M.A., Azab, A.M.S., Rawash, Z.M.
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	antioxidants chlorpyrifos histopathology semen spermatogenic cycle Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2020.85588 https://doaj.org/article/7f9fd99a998243baa4ef720e9a9214f8
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spelling	oai:doaj.org-article:7f9fd99a998243baa4ef720e9a9214f82021-12-02T17:04:15ZToxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Ratshttps://dx.doi.org/10.21608/javs.2020.855881687-40722090-3308https://doaj.org/article/7f9fd99a998243baa4ef720e9a9214f82020-04-01T00:00:00Zhttps://javs.journals.ekb.eg/article_85588.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308This study was carried out on 30 mature male albino rats (2 months old, weighed about 130 g) in 3 groups of ten rats for each one in ARC. Group I, kept as control. Group II, daily intubated with CPF, at a dose level of 10.6 mg/kg BW in corn oil. Group III, daily intubated with CPF at a dose level of 10.6 mg/kg BW, zinc at a dose level of 227 mg/kg BW and vitamin E at a dose level of 75 mg/kg BW for 50 days equivalent to one spermatogenic cycle in rats. At the end of the experiment, the rats were sacrificed to take blood, semen and tissue specimens. Histopathologically, the testes and epididymis showed moderate degeneration and thickening of the tubular membrane with interstitial oedema in the CPF intoxicated group. These changes were ameliorated in the rats of group III. The semen analysis is aggressively badly affected in the CPF intoxicated group in comparison with the control group and improved in rats of group III. Testosterone hormone levels were assayed with ELISA technique as 3.871±0.31 ng/ml, 1.112±0.82 ng/ml, and 2.503±0.25 ng/ml in control, CPF, CPF plus vitamin E and Zn groups, respectively. Moreover, the DNA integrity of spermatozoa in the CPF group was severely affected in comparison with either the control group and group III.Assi, M.M.A.Azab, A.M.S.Rawash, Z.M.Egyptian Society for Animal Managementarticleantioxidantschlorpyrifoshistopathologysemenspermatogenic cycleZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 2, Pp 67-76 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidants chlorpyrifos histopathology semen spermatogenic cycle Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	antioxidants chlorpyrifos histopathology semen spermatogenic cycle Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Assi, M.M.A. Azab, A.M.S. Rawash, Z.M. Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats
description	This study was carried out on 30 mature male albino rats (2 months old, weighed about 130 g) in 3 groups of ten rats for each one in ARC. Group I, kept as control. Group II, daily intubated with CPF, at a dose level of 10.6 mg/kg BW in corn oil. Group III, daily intubated with CPF at a dose level of 10.6 mg/kg BW, zinc at a dose level of 227 mg/kg BW and vitamin E at a dose level of 75 mg/kg BW for 50 days equivalent to one spermatogenic cycle in rats. At the end of the experiment, the rats were sacrificed to take blood, semen and tissue specimens. Histopathologically, the testes and epididymis showed moderate degeneration and thickening of the tubular membrane with interstitial oedema in the CPF intoxicated group. These changes were ameliorated in the rats of group III. The semen analysis is aggressively badly affected in the CPF intoxicated group in comparison with the control group and improved in rats of group III. Testosterone hormone levels were assayed with ELISA technique as 3.871±0.31 ng/ml, 1.112±0.82 ng/ml, and 2.503±0.25 ng/ml in control, CPF, CPF plus vitamin E and Zn groups, respectively. Moreover, the DNA integrity of spermatozoa in the CPF group was severely affected in comparison with either the control group and group III.
format	article
author	Assi, M.M.A. Azab, A.M.S. Rawash, Z.M.
author_facet	Assi, M.M.A. Azab, A.M.S. Rawash, Z.M.
author_sort	Assi, M.M.A.
title	Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats
title_short	Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats
title_full	Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats
title_fullStr	Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats
title_full_unstemmed	Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats
title_sort	toxicopathological impacts of chlorpyrifos on sperm qualities and testicular tissue alterations and their modulation with vitamin e and zinc in male albino rats
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2020.85588 https://doaj.org/article/7f9fd99a998243baa4ef720e9a9214f8
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Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats

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