Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

The stereochemistry of the plant heteroyohimbine alkaloids is a key factor determining their diverse biological activities. Here, the authors carry out structural, localization and genetic experiments to understand the mechanism of stereoselectivity for three heteroyohimbine synthases and to identif...

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Autores principales:	Anna Stavrinides, Evangelos C. Tatsis, Lorenzo Caputi, Emilien Foureau, Clare E. M. Stevenson, David M. Lawson, Vincent Courdavault, Sarah E. O'Connor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7fa19d5198334538bd3e87a811316141
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spelling	oai:doaj.org-article:7fa19d5198334538bd3e87a8113161412021-12-02T14:40:12ZStructural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity10.1038/ncomms121162041-1723https://doaj.org/article/7fa19d5198334538bd3e87a8113161412016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12116https://doaj.org/toc/2041-1723The stereochemistry of the plant heteroyohimbine alkaloids is a key factor determining their diverse biological activities. Here, the authors carry out structural, localization and genetic experiments to understand the mechanism of stereoselectivity for three heteroyohimbine synthases and to identify their function in vivo.Anna StavrinidesEvangelos C. TatsisLorenzo CaputiEmilien FoureauClare E. M. StevensonDavid M. LawsonVincent CourdavaultSarah E. O'ConnorNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna Stavrinides Evangelos C. Tatsis Lorenzo Caputi Emilien Foureau Clare E. M. Stevenson David M. Lawson Vincent Courdavault Sarah E. O'Connor Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
description	The stereochemistry of the plant heteroyohimbine alkaloids is a key factor determining their diverse biological activities. Here, the authors carry out structural, localization and genetic experiments to understand the mechanism of stereoselectivity for three heteroyohimbine synthases and to identify their function in vivo.
format	article
author	Anna Stavrinides Evangelos C. Tatsis Lorenzo Caputi Emilien Foureau Clare E. M. Stevenson David M. Lawson Vincent Courdavault Sarah E. O'Connor
author_facet	Anna Stavrinides Evangelos C. Tatsis Lorenzo Caputi Emilien Foureau Clare E. M. Stevenson David M. Lawson Vincent Courdavault Sarah E. O'Connor
author_sort	Anna Stavrinides
title	Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
title_short	Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
title_full	Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
title_fullStr	Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
title_full_unstemmed	Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
title_sort	structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7fa19d5198334538bd3e87a811316141
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_version_	1718390366135123968

Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

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