Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
The stereochemistry of the plant heteroyohimbine alkaloids is a key factor determining their diverse biological activities. Here, the authors carry out structural, localization and genetic experiments to understand the mechanism of stereoselectivity for three heteroyohimbine synthases and to identif...
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Autores principales: | Anna Stavrinides, Evangelos C. Tatsis, Lorenzo Caputi, Emilien Foureau, Clare E. M. Stevenson, David M. Lawson, Vincent Courdavault, Sarah E. O'Connor |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
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Materias: | |
Acceso en línea: | https://doaj.org/article/7fa19d5198334538bd3e87a811316141 |
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