Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

The stereochemistry of the plant heteroyohimbine alkaloids is a key factor determining their diverse biological activities. Here, the authors carry out structural, localization and genetic experiments to understand the mechanism of stereoselectivity for three heteroyohimbine synthases and to identif...

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Autores principales: Anna Stavrinides, Evangelos C. Tatsis, Lorenzo Caputi, Emilien Foureau, Clare E. M. Stevenson, David M. Lawson, Vincent Courdavault, Sarah E. O'Connor
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/7fa19d5198334538bd3e87a811316141
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