Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome

Abstract Concussions are associated with a range of cognitive, neuropsychological and behavioral sequelae that, at times, persist beyond typical recovery times and are referred to as postconcussion syndrome (PCS). There is growing support that concussion can disrupt network-based connectivity post-i...

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Autores principales:	Reema Shafi, Adrian P. Crawley, Maria Carmela Tartaglia, Charles H. Tator, Robin E. Green, David J. Mikulis, Angela Colantonio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7fa6b3f28b5e4e0c873f7a592116a371
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spelling	oai:doaj.org-article:7fa6b3f28b5e4e0c873f7a592116a3712021-12-02T11:57:56ZSex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome10.1038/s41598-020-77137-42045-2322https://doaj.org/article/7fa6b3f28b5e4e0c873f7a592116a3712020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77137-4https://doaj.org/toc/2045-2322Abstract Concussions are associated with a range of cognitive, neuropsychological and behavioral sequelae that, at times, persist beyond typical recovery times and are referred to as postconcussion syndrome (PCS). There is growing support that concussion can disrupt network-based connectivity post-injury. To date, a significant knowledge gap remains regarding the sex-specific impact of concussion on resting state functional connectivity (rs-FC). The aims of this study were to (1) investigate the injury-based rs-FC differences across three large-scale neural networks and (2) explore the sex-specific impact of injury on network-based connectivity. MRI data was collected from a sample of 80 concussed participants who fulfilled the criteria for postconcussion syndrome and 31 control participants who did not have any history of concussion. Connectivity maps between network nodes and brain regions were used to assess connectivity using the Functional Connectivity (CONN) toolbox. Network based statistics showed that concussed participants were significantly different from healthy controls across both salience and fronto-parietal network nodes. More specifically, distinct subnetwork components were identified in the concussed sample, with hyperconnected frontal nodes and hypoconnected posterior nodes across both the salience and fronto-parietal networks, when compared to the healthy controls. Node-to-region analyses showed sex-specific differences across association cortices, however, driven by distinct networks. Sex-specific network-based alterations in rs-FC post concussion need to be examined to better understand the underlying mechanisms and associations to clinical outcomes.Reema ShafiAdrian P. CrawleyMaria Carmela TartagliaCharles H. TatorRobin E. GreenDavid J. MikulisAngela ColantonioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reema Shafi Adrian P. Crawley Maria Carmela Tartaglia Charles H. Tator Robin E. Green David J. Mikulis Angela Colantonio Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome
description	Abstract Concussions are associated with a range of cognitive, neuropsychological and behavioral sequelae that, at times, persist beyond typical recovery times and are referred to as postconcussion syndrome (PCS). There is growing support that concussion can disrupt network-based connectivity post-injury. To date, a significant knowledge gap remains regarding the sex-specific impact of concussion on resting state functional connectivity (rs-FC). The aims of this study were to (1) investigate the injury-based rs-FC differences across three large-scale neural networks and (2) explore the sex-specific impact of injury on network-based connectivity. MRI data was collected from a sample of 80 concussed participants who fulfilled the criteria for postconcussion syndrome and 31 control participants who did not have any history of concussion. Connectivity maps between network nodes and brain regions were used to assess connectivity using the Functional Connectivity (CONN) toolbox. Network based statistics showed that concussed participants were significantly different from healthy controls across both salience and fronto-parietal network nodes. More specifically, distinct subnetwork components were identified in the concussed sample, with hyperconnected frontal nodes and hypoconnected posterior nodes across both the salience and fronto-parietal networks, when compared to the healthy controls. Node-to-region analyses showed sex-specific differences across association cortices, however, driven by distinct networks. Sex-specific network-based alterations in rs-FC post concussion need to be examined to better understand the underlying mechanisms and associations to clinical outcomes.
format	article
author	Reema Shafi Adrian P. Crawley Maria Carmela Tartaglia Charles H. Tator Robin E. Green David J. Mikulis Angela Colantonio
author_facet	Reema Shafi Adrian P. Crawley Maria Carmela Tartaglia Charles H. Tator Robin E. Green David J. Mikulis Angela Colantonio
author_sort	Reema Shafi
title	Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome
title_short	Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome
title_full	Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome
title_fullStr	Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome
title_full_unstemmed	Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome
title_sort	sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7fa6b3f28b5e4e0c873f7a592116a371
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Sex-specific differences in resting-state functional connectivity of large-scale networks in postconcussion syndrome

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