Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease

(1) Background: The role of adipokines such as adiponectin and visfatin in metabolic-dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease remains unclear. Therefore, we aim to assess serum adiponectin and visfatin levels in MAFLD patients and associated cardiovascular parame...

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Autores principales:	Abdulrahman Ismaiel, Mihail Spinu, Livia Budisan, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Bogdan Augustin Chis, Ioana Berindan-Neagoe, Dan Mircea Olinic, Dan L. Dumitrascu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metabolic-dysfunction-associated fatty liver disease (MAFLD) hepatic steatosis SteatoTest adipokines adiponectin visfatin Medicine R
Acceso en línea:	https://doaj.org/article/7fa753d3ac1349f4a3524c9ddb0b16fe
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spelling	oai:doaj.org-article:7fa753d3ac1349f4a3524c9ddb0b16fe2021-11-11T17:47:57ZRelationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease10.3390/jcm102151942077-0383https://doaj.org/article/7fa753d3ac1349f4a3524c9ddb0b16fe2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5194https://doaj.org/toc/2077-0383(1) Background: The role of adipokines such as adiponectin and visfatin in metabolic-dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease remains unclear. Therefore, we aim to assess serum adiponectin and visfatin levels in MAFLD patients and associated cardiovascular parameters. (2) Methods: A cross-sectional study involving 80 participants (40 MAFLD patients, 40 controls), recruited between January and September 2020, was conducted, using both hepatic ultrasonography and SteatoTestTM to evaluate hepatic steatosis. Echocardiographic and Doppler parameters were assessed. Serum adipokines were measured using ELISA kits. (3) Results: Adiponectin and visfatin levels were not significantly different in MAFLD vs. controls. Visfatin was associated with mean carotid intima-media thickness (<i>p</i>-value = 0.047), while adiponectin was associated with left ventricular ejection fraction (LVEF) (<i>p</i>-value = 0.039) and E/A ratio (<i>p</i>-value = 0.002) in controls. The association between adiponectin and E/A ratio was significant in the univariate analysis at 95% CI (0.0049–0.1331, <i>p</i>-value = 0.035), but lost significance after the multivariate analysis. Although LVEF was not associated with adiponectin in the univariate analysis, significant values were observed after the multivariate analysis (95% CI (−1.83–−0.22, <i>p</i>-value = 0.015)). (4) Conclusions: No significant difference in serum adiponectin and visfatin levels in MAFLD patients vs. controls was found. Interestingly, although adiponectin levels were not associated with LVEF in the univariate analysis, a significant inversely proportional association was observed after the multivariate analysis.Abdulrahman IsmaielMihail SpinuLivia BudisanDaniel-Corneliu LeucutaStefan-Lucian PopaBogdan Augustin ChisIoana Berindan-NeagoeDan Mircea OlinicDan L. DumitrascuMDPI AGarticlemetabolic-dysfunction-associated fatty liver disease (MAFLD)hepatic steatosisSteatoTestadipokinesadiponectinvisfatinMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5194, p 5194 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic-dysfunction-associated fatty liver disease (MAFLD) hepatic steatosis SteatoTest adipokines adiponectin visfatin Medicine R
spellingShingle	metabolic-dysfunction-associated fatty liver disease (MAFLD) hepatic steatosis SteatoTest adipokines adiponectin visfatin Medicine R Abdulrahman Ismaiel Mihail Spinu Livia Budisan Daniel-Corneliu Leucuta Stefan-Lucian Popa Bogdan Augustin Chis Ioana Berindan-Neagoe Dan Mircea Olinic Dan L. Dumitrascu Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease
description	(1) Background: The role of adipokines such as adiponectin and visfatin in metabolic-dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease remains unclear. Therefore, we aim to assess serum adiponectin and visfatin levels in MAFLD patients and associated cardiovascular parameters. (2) Methods: A cross-sectional study involving 80 participants (40 MAFLD patients, 40 controls), recruited between January and September 2020, was conducted, using both hepatic ultrasonography and SteatoTestTM to evaluate hepatic steatosis. Echocardiographic and Doppler parameters were assessed. Serum adipokines were measured using ELISA kits. (3) Results: Adiponectin and visfatin levels were not significantly different in MAFLD vs. controls. Visfatin was associated with mean carotid intima-media thickness (<i>p</i>-value = 0.047), while adiponectin was associated with left ventricular ejection fraction (LVEF) (<i>p</i>-value = 0.039) and E/A ratio (<i>p</i>-value = 0.002) in controls. The association between adiponectin and E/A ratio was significant in the univariate analysis at 95% CI (0.0049–0.1331, <i>p</i>-value = 0.035), but lost significance after the multivariate analysis. Although LVEF was not associated with adiponectin in the univariate analysis, significant values were observed after the multivariate analysis (95% CI (−1.83–−0.22, <i>p</i>-value = 0.015)). (4) Conclusions: No significant difference in serum adiponectin and visfatin levels in MAFLD patients vs. controls was found. Interestingly, although adiponectin levels were not associated with LVEF in the univariate analysis, a significant inversely proportional association was observed after the multivariate analysis.
format	article
author	Abdulrahman Ismaiel Mihail Spinu Livia Budisan Daniel-Corneliu Leucuta Stefan-Lucian Popa Bogdan Augustin Chis Ioana Berindan-Neagoe Dan Mircea Olinic Dan L. Dumitrascu
author_facet	Abdulrahman Ismaiel Mihail Spinu Livia Budisan Daniel-Corneliu Leucuta Stefan-Lucian Popa Bogdan Augustin Chis Ioana Berindan-Neagoe Dan Mircea Olinic Dan L. Dumitrascu
author_sort	Abdulrahman Ismaiel
title	Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease
title_short	Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease
title_full	Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease
title_fullStr	Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease
title_full_unstemmed	Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease
title_sort	relationship between adipokines and cardiovascular ultrasound parameters in metabolic-dysfunction-associated fatty liver disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7fa753d3ac1349f4a3524c9ddb0b16fe
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Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease

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