Epigenetic modulation reveals differentiation state specificity of oncogene addiction

Epigenetic mechanisms associated with the differentiation state of cancer cells and their heterogeneity influence tumor responses to oncogene-targeted therapies. In this study, the authors perform an epigenetic compound screen and single-cell analysis in BRAF-mutant melanoma cells to identify compou...

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Autores principales:	Mehwish Khaliq, Mohan Manikkam, Elisabeth D. Martinez, Mohammad Fallahi-Sichani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7fa8d14fcf1945ae8d04495e5d1b8978
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spelling	oai:doaj.org-article:7fa8d14fcf1945ae8d04495e5d1b89782021-12-02T13:32:50ZEpigenetic modulation reveals differentiation state specificity of oncogene addiction10.1038/s41467-021-21784-22041-1723https://doaj.org/article/7fa8d14fcf1945ae8d04495e5d1b89782021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21784-2https://doaj.org/toc/2041-1723Epigenetic mechanisms associated with the differentiation state of cancer cells and their heterogeneity influence tumor responses to oncogene-targeted therapies. In this study, the authors perform an epigenetic compound screen and single-cell analysis in BRAF-mutant melanoma cells to identify compounds that block three distinct drug-tolerant epigenetic states associated with either one of the lysine-specific histone demethylases Kdm1a or Kdm4b, or BET proteins.Mehwish KhaliqMohan ManikkamElisabeth D. MartinezMohammad Fallahi-SichaniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mehwish Khaliq Mohan Manikkam Elisabeth D. Martinez Mohammad Fallahi-Sichani Epigenetic modulation reveals differentiation state specificity of oncogene addiction
description	Epigenetic mechanisms associated with the differentiation state of cancer cells and their heterogeneity influence tumor responses to oncogene-targeted therapies. In this study, the authors perform an epigenetic compound screen and single-cell analysis in BRAF-mutant melanoma cells to identify compounds that block three distinct drug-tolerant epigenetic states associated with either one of the lysine-specific histone demethylases Kdm1a or Kdm4b, or BET proteins.
format	article
author	Mehwish Khaliq Mohan Manikkam Elisabeth D. Martinez Mohammad Fallahi-Sichani
author_facet	Mehwish Khaliq Mohan Manikkam Elisabeth D. Martinez Mohammad Fallahi-Sichani
author_sort	Mehwish Khaliq
title	Epigenetic modulation reveals differentiation state specificity of oncogene addiction
title_short	Epigenetic modulation reveals differentiation state specificity of oncogene addiction
title_full	Epigenetic modulation reveals differentiation state specificity of oncogene addiction
title_fullStr	Epigenetic modulation reveals differentiation state specificity of oncogene addiction
title_full_unstemmed	Epigenetic modulation reveals differentiation state specificity of oncogene addiction
title_sort	epigenetic modulation reveals differentiation state specificity of oncogene addiction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7fa8d14fcf1945ae8d04495e5d1b8978
work_keys_str_mv	AT mehwishkhaliq epigeneticmodulationrevealsdifferentiationstatespecificityofoncogeneaddiction AT mohanmanikkam epigeneticmodulationrevealsdifferentiationstatespecificityofoncogeneaddiction AT elisabethdmartinez epigeneticmodulationrevealsdifferentiationstatespecificityofoncogeneaddiction AT mohammadfallahisichani epigeneticmodulationrevealsdifferentiationstatespecificityofoncogeneaddiction
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Epigenetic modulation reveals differentiation state specificity of oncogene addiction

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