TGFβ signaling curbs cell fusion and muscle regeneration
The fusion of muscle progenitor cells to form syncytial myofibers is required for skeletal muscle development and regeneration. Here, the authors describe a novel and specific molecular regulation of muscle cell fusion driven by transforming growth factor beta (TGFβ) signaling.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/7fadbaa35ce8442d9d056195a3a35cf8 |
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oai:doaj.org-article:7fadbaa35ce8442d9d056195a3a35cf82021-12-02T10:44:12ZTGFβ signaling curbs cell fusion and muscle regeneration10.1038/s41467-020-20289-82041-1723https://doaj.org/article/7fadbaa35ce8442d9d056195a3a35cf82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20289-8https://doaj.org/toc/2041-1723The fusion of muscle progenitor cells to form syncytial myofibers is required for skeletal muscle development and regeneration. Here, the authors describe a novel and specific molecular regulation of muscle cell fusion driven by transforming growth factor beta (TGFβ) signaling.Francesco GirardiAnissa TalebMajid EbrahimiAsiman DatyeDilani G. GamageCécile PeccateLorenzo GiordaniDouglas P. MillayPenney M. GilbertBruno CadotFabien Le GrandNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Francesco Girardi Anissa Taleb Majid Ebrahimi Asiman Datye Dilani G. Gamage Cécile Peccate Lorenzo Giordani Douglas P. Millay Penney M. Gilbert Bruno Cadot Fabien Le Grand TGFβ signaling curbs cell fusion and muscle regeneration |
| description |
The fusion of muscle progenitor cells to form syncytial myofibers is required for skeletal muscle development and regeneration. Here, the authors describe a novel and specific molecular regulation of muscle cell fusion driven by transforming growth factor beta (TGFβ) signaling. |
| format |
article |
| author |
Francesco Girardi Anissa Taleb Majid Ebrahimi Asiman Datye Dilani G. Gamage Cécile Peccate Lorenzo Giordani Douglas P. Millay Penney M. Gilbert Bruno Cadot Fabien Le Grand |
| author_facet |
Francesco Girardi Anissa Taleb Majid Ebrahimi Asiman Datye Dilani G. Gamage Cécile Peccate Lorenzo Giordani Douglas P. Millay Penney M. Gilbert Bruno Cadot Fabien Le Grand |
| author_sort |
Francesco Girardi |
| title |
TGFβ signaling curbs cell fusion and muscle regeneration |
| title_short |
TGFβ signaling curbs cell fusion and muscle regeneration |
| title_full |
TGFβ signaling curbs cell fusion and muscle regeneration |
| title_fullStr |
TGFβ signaling curbs cell fusion and muscle regeneration |
| title_full_unstemmed |
TGFβ signaling curbs cell fusion and muscle regeneration |
| title_sort |
tgfβ signaling curbs cell fusion and muscle regeneration |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7fadbaa35ce8442d9d056195a3a35cf8 |
| work_keys_str_mv |
AT francescogirardi tgfbsignalingcurbscellfusionandmuscleregeneration AT anissataleb tgfbsignalingcurbscellfusionandmuscleregeneration AT majidebrahimi tgfbsignalingcurbscellfusionandmuscleregeneration AT asimandatye tgfbsignalingcurbscellfusionandmuscleregeneration AT dilaniggamage tgfbsignalingcurbscellfusionandmuscleregeneration AT cecilepeccate tgfbsignalingcurbscellfusionandmuscleregeneration AT lorenzogiordani tgfbsignalingcurbscellfusionandmuscleregeneration AT douglaspmillay tgfbsignalingcurbscellfusionandmuscleregeneration AT penneymgilbert tgfbsignalingcurbscellfusionandmuscleregeneration AT brunocadot tgfbsignalingcurbscellfusionandmuscleregeneration AT fabienlegrand tgfbsignalingcurbscellfusionandmuscleregeneration |
| _version_ |
1718396771794681856 |