Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances

Autophagy is a crucial general survival tactic of mammalian cells. It describes the capability of cells to disassemble and partially recycle cellular components (e.g., mitochondria) in case they are damaged and pose a risk to cell survival or simply if their resources are urgently needed elsewhere a...

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Autores principales:	Ingo Ganzleben, Markus F. Neurath, Christoph Becker
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autophagy mitophagy glutamine cancer reverse Warburg effect hydroxychloroquine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7fafd0c438094b7bb78e626e620dd514
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id	oai:doaj.org-article:7fafd0c438094b7bb78e626e620dd514
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spelling	oai:doaj.org-article:7fafd0c438094b7bb78e626e620dd5142021-11-11T15:35:45ZAutophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances10.3390/cancers132155752072-6694https://doaj.org/article/7fafd0c438094b7bb78e626e620dd5142021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5575https://doaj.org/toc/2072-6694Autophagy is a crucial general survival tactic of mammalian cells. It describes the capability of cells to disassemble and partially recycle cellular components (e.g., mitochondria) in case they are damaged and pose a risk to cell survival or simply if their resources are urgently needed elsewhere at the time. Autophagy-associated pathomechanisms have been increasingly recognized as important disease mechanisms in non-malignant (neurodegeneration, diffuse parenchymal lung disease) and malignant conditions alike. However, the overall consequences of autophagy for the organism depend particularly on the greater context in which autophagy occurs, such as the cell type or whether the cell is proliferating. In cancer, autophagy sustains cancer cell survival under challenging, i.e., resource-depleted, conditions. However, this leads to situations in which cancer cells are completely dependent on autophagy. Accordingly, autophagy represents a promising yet complex target in cancer treatment with therapeutically induced increase and decrease of autophagic flux as important therapeutic principles.Ingo GanzlebenMarkus F. NeurathChristoph BeckerMDPI AGarticleautophagymitophagyglutaminecancerreverse Warburg effecthydroxychloroquineNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5575, p 5575 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autophagy mitophagy glutamine cancer reverse Warburg effect hydroxychloroquine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	autophagy mitophagy glutamine cancer reverse Warburg effect hydroxychloroquine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ingo Ganzleben Markus F. Neurath Christoph Becker Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances
description	Autophagy is a crucial general survival tactic of mammalian cells. It describes the capability of cells to disassemble and partially recycle cellular components (e.g., mitochondria) in case they are damaged and pose a risk to cell survival or simply if their resources are urgently needed elsewhere at the time. Autophagy-associated pathomechanisms have been increasingly recognized as important disease mechanisms in non-malignant (neurodegeneration, diffuse parenchymal lung disease) and malignant conditions alike. However, the overall consequences of autophagy for the organism depend particularly on the greater context in which autophagy occurs, such as the cell type or whether the cell is proliferating. In cancer, autophagy sustains cancer cell survival under challenging, i.e., resource-depleted, conditions. However, this leads to situations in which cancer cells are completely dependent on autophagy. Accordingly, autophagy represents a promising yet complex target in cancer treatment with therapeutically induced increase and decrease of autophagic flux as important therapeutic principles.
format	article
author	Ingo Ganzleben Markus F. Neurath Christoph Becker
author_facet	Ingo Ganzleben Markus F. Neurath Christoph Becker
author_sort	Ingo Ganzleben
title	Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances
title_short	Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances
title_full	Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances
title_fullStr	Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances
title_full_unstemmed	Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances
title_sort	autophagy in cancer therapy—molecular mechanisms and current clinical advances
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7fafd0c438094b7bb78e626e620dd514
work_keys_str_mv	AT ingoganzleben autophagyincancertherapymolecularmechanismsandcurrentclinicaladvances AT markusfneurath autophagyincancertherapymolecularmechanismsandcurrentclinicaladvances AT christophbecker autophagyincancertherapymolecularmechanismsandcurrentclinicaladvances
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Autophagy in Cancer Therapy—Molecular Mechanisms and Current Clinical Advances

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