Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights

Metal carbene is usually employed as a 1-carbon synthon or 3-carbon synthon in a variety of cycloaddition reactions. Here, the authors report a gold-catalyzed cascade protocol for the assembly of polycarbocyclic frameworks via a β-aryl gold-carbene intermediate which reacts as a 4-carbon synthon wit...

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Autores principales:	Cheng Zhang, Kemiao Hong, Chao Pei, Su Zhou, Wenhao Hu, A. Stephen K. Hashmi, Xinfang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7fafd4ff43774eb5a251196358d29376
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spelling	oai:doaj.org-article:7fafd4ff43774eb5a251196358d293762021-12-02T10:54:03ZGold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights10.1038/s41467-021-21335-92041-1723https://doaj.org/article/7fafd4ff43774eb5a251196358d293762021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21335-9https://doaj.org/toc/2041-1723Metal carbene is usually employed as a 1-carbon synthon or 3-carbon synthon in a variety of cycloaddition reactions. Here, the authors report a gold-catalyzed cascade protocol for the assembly of polycarbocyclic frameworks via a β-aryl gold-carbene intermediate which reacts as a 4-carbon synthon with alkenes in [4 + 2]-cycloadditions.Cheng ZhangKemiao HongChao PeiSu ZhouWenhao HuA. Stephen K. HashmiXinfang XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng Zhang Kemiao Hong Chao Pei Su Zhou Wenhao Hu A. Stephen K. Hashmi Xinfang Xu Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights
description	Metal carbene is usually employed as a 1-carbon synthon or 3-carbon synthon in a variety of cycloaddition reactions. Here, the authors report a gold-catalyzed cascade protocol for the assembly of polycarbocyclic frameworks via a β-aryl gold-carbene intermediate which reacts as a 4-carbon synthon with alkenes in [4 + 2]-cycloadditions.
format	article
author	Cheng Zhang Kemiao Hong Chao Pei Su Zhou Wenhao Hu A. Stephen K. Hashmi Xinfang Xu
author_facet	Cheng Zhang Kemiao Hong Chao Pei Su Zhou Wenhao Hu A. Stephen K. Hashmi Xinfang Xu
author_sort	Cheng Zhang
title	Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights
title_short	Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights
title_full	Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights
title_fullStr	Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights
title_full_unstemmed	Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights
title_sort	gold(i)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7fafd4ff43774eb5a251196358d29376
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Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights

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