Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Age-related tissue alterations have been associated with a decline in stem cell number and function. Here the authors report a single cell multi-omics study of mouse muscle stem cells, combining single cell transcriptome and DNA methylome profiling and find that aged cells have a global increase of...

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Autores principales: Irene Hernando-Herraez, Brendan Evano, Thomas Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen Clark, Simon Andrews, Shahragim Tajbakhsh, Wolf Reik
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7fb038d80fdb4c259027e99923ca8c58
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spelling oai:doaj.org-article:7fb038d80fdb4c259027e99923ca8c582021-12-02T16:58:01ZAgeing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells10.1038/s41467-019-12293-42041-1723https://doaj.org/article/7fb038d80fdb4c259027e99923ca8c582019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12293-4https://doaj.org/toc/2041-1723Age-related tissue alterations have been associated with a decline in stem cell number and function. Here the authors report a single cell multi-omics study of mouse muscle stem cells, combining single cell transcriptome and DNA methylome profiling and find that aged cells have a global increase of uncoordinated transcriptional heterogeneity biased towards genes regulating cell-niche interactions.Irene Hernando-HerraezBrendan EvanoThomas StubbsPierre-Henri CommereMarc Jan BonderStephen ClarkSimon AndrewsShahragim TajbakhshWolf ReikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Irene Hernando-Herraez
Brendan Evano
Thomas Stubbs
Pierre-Henri Commere
Marc Jan Bonder
Stephen Clark
Simon Andrews
Shahragim Tajbakhsh
Wolf Reik
Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
description Age-related tissue alterations have been associated with a decline in stem cell number and function. Here the authors report a single cell multi-omics study of mouse muscle stem cells, combining single cell transcriptome and DNA methylome profiling and find that aged cells have a global increase of uncoordinated transcriptional heterogeneity biased towards genes regulating cell-niche interactions.
format article
author Irene Hernando-Herraez
Brendan Evano
Thomas Stubbs
Pierre-Henri Commere
Marc Jan Bonder
Stephen Clark
Simon Andrews
Shahragim Tajbakhsh
Wolf Reik
author_facet Irene Hernando-Herraez
Brendan Evano
Thomas Stubbs
Pierre-Henri Commere
Marc Jan Bonder
Stephen Clark
Simon Andrews
Shahragim Tajbakhsh
Wolf Reik
author_sort Irene Hernando-Herraez
title Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_short Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_full Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_fullStr Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_full_unstemmed Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_sort ageing affects dna methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/7fb038d80fdb4c259027e99923ca8c58
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AT brendanevano ageingaffectsdnamethylationdriftandtranscriptionalcelltocellvariabilityinmousemusclestemcells
AT thomasstubbs ageingaffectsdnamethylationdriftandtranscriptionalcelltocellvariabilityinmousemusclestemcells
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