Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Age-related tissue alterations have been associated with a decline in stem cell number and function. Here the authors report a single cell multi-omics study of mouse muscle stem cells, combining single cell transcriptome and DNA methylome profiling and find that aged cells have a global increase of...

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Auteurs principaux:	Irene Hernando-Herraez, Brendan Evano, Thomas Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen Clark, Simon Andrews, Shahragim Tajbakhsh, Wolf Reik
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/7fb038d80fdb4c259027e99923ca8c58
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id	oai:doaj.org-article:7fb038d80fdb4c259027e99923ca8c58
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spelling	oai:doaj.org-article:7fb038d80fdb4c259027e99923ca8c582021-12-02T16:58:01ZAgeing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells10.1038/s41467-019-12293-42041-1723https://doaj.org/article/7fb038d80fdb4c259027e99923ca8c582019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12293-4https://doaj.org/toc/2041-1723Age-related tissue alterations have been associated with a decline in stem cell number and function. Here the authors report a single cell multi-omics study of mouse muscle stem cells, combining single cell transcriptome and DNA methylome profiling and find that aged cells have a global increase of uncoordinated transcriptional heterogeneity biased towards genes regulating cell-niche interactions.Irene Hernando-HerraezBrendan EvanoThomas StubbsPierre-Henri CommereMarc Jan BonderStephen ClarkSimon AndrewsShahragim TajbakhshWolf ReikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irene Hernando-Herraez Brendan Evano Thomas Stubbs Pierre-Henri Commere Marc Jan Bonder Stephen Clark Simon Andrews Shahragim Tajbakhsh Wolf Reik Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
description	Age-related tissue alterations have been associated with a decline in stem cell number and function. Here the authors report a single cell multi-omics study of mouse muscle stem cells, combining single cell transcriptome and DNA methylome profiling and find that aged cells have a global increase of uncoordinated transcriptional heterogeneity biased towards genes regulating cell-niche interactions.
format	article
author	Irene Hernando-Herraez Brendan Evano Thomas Stubbs Pierre-Henri Commere Marc Jan Bonder Stephen Clark Simon Andrews Shahragim Tajbakhsh Wolf Reik
author_facet	Irene Hernando-Herraez Brendan Evano Thomas Stubbs Pierre-Henri Commere Marc Jan Bonder Stephen Clark Simon Andrews Shahragim Tajbakhsh Wolf Reik
author_sort	Irene Hernando-Herraez
title	Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_short	Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_full	Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_fullStr	Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_full_unstemmed	Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
title_sort	ageing affects dna methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7fb038d80fdb4c259027e99923ca8c58
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Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

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