Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.
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Nature Portfolio
2018
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oai:doaj.org-article:7fb05d6f62c94a08a8f144e58ba79a092021-12-02T17:31:27ZNeuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms10.1038/s41467-018-03045-x2041-1723https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a092018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03045-xhttps://doaj.org/toc/2041-1723Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.Christopher H. DouseStuart BloorYangci LiuMaria ShaminIva A. TchasovnikarovaRichard T. TimmsPaul J. LehnerYorgo ModisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q |
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Science Q Christopher H. Douse Stuart Bloor Yangci Liu Maria Shamin Iva A. Tchasovnikarova Richard T. Timms Paul J. Lehner Yorgo Modis Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms |
description |
Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing. |
format |
article |
author |
Christopher H. Douse Stuart Bloor Yangci Liu Maria Shamin Iva A. Tchasovnikarova Richard T. Timms Paul J. Lehner Yorgo Modis |
author_facet |
Christopher H. Douse Stuart Bloor Yangci Liu Maria Shamin Iva A. Tchasovnikarova Richard T. Timms Paul J. Lehner Yorgo Modis |
author_sort |
Christopher H. Douse |
title |
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms |
title_short |
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms |
title_full |
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms |
title_fullStr |
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms |
title_full_unstemmed |
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms |
title_sort |
neuropathic morc2 mutations perturb ghkl atpase dimerization dynamics and epigenetic silencing by multiple structural mechanisms |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a09 |
work_keys_str_mv |
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