Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.

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Autores principales: Christopher H. Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A. Tchasovnikarova, Richard T. Timms, Paul J. Lehner, Yorgo Modis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a09
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spelling oai:doaj.org-article:7fb05d6f62c94a08a8f144e58ba79a092021-12-02T17:31:27ZNeuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms10.1038/s41467-018-03045-x2041-1723https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a092018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03045-xhttps://doaj.org/toc/2041-1723Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.Christopher H. DouseStuart BloorYangci LiuMaria ShaminIva A. TchasovnikarovaRichard T. TimmsPaul J. LehnerYorgo ModisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christopher H. Douse
Stuart Bloor
Yangci Liu
Maria Shamin
Iva A. Tchasovnikarova
Richard T. Timms
Paul J. Lehner
Yorgo Modis
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
description Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.
format article
author Christopher H. Douse
Stuart Bloor
Yangci Liu
Maria Shamin
Iva A. Tchasovnikarova
Richard T. Timms
Paul J. Lehner
Yorgo Modis
author_facet Christopher H. Douse
Stuart Bloor
Yangci Liu
Maria Shamin
Iva A. Tchasovnikarova
Richard T. Timms
Paul J. Lehner
Yorgo Modis
author_sort Christopher H. Douse
title Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_short Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_full Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_fullStr Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_full_unstemmed Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_sort neuropathic morc2 mutations perturb ghkl atpase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a09
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