Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.

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Auteurs principaux:	Christopher H. Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A. Tchasovnikarova, Richard T. Timms, Paul J. Lehner, Yorgo Modis
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a09
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spelling	oai:doaj.org-article:7fb05d6f62c94a08a8f144e58ba79a092021-12-02T17:31:27ZNeuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms10.1038/s41467-018-03045-x2041-1723https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a092018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03045-xhttps://doaj.org/toc/2041-1723Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.Christopher H. DouseStuart BloorYangci LiuMaria ShaminIva A. TchasovnikarovaRichard T. TimmsPaul J. LehnerYorgo ModisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher H. Douse Stuart Bloor Yangci Liu Maria Shamin Iva A. Tchasovnikarova Richard T. Timms Paul J. Lehner Yorgo Modis Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
description	Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.
format	article
author	Christopher H. Douse Stuart Bloor Yangci Liu Maria Shamin Iva A. Tchasovnikarova Richard T. Timms Paul J. Lehner Yorgo Modis
author_facet	Christopher H. Douse Stuart Bloor Yangci Liu Maria Shamin Iva A. Tchasovnikarova Richard T. Timms Paul J. Lehner Yorgo Modis
author_sort	Christopher H. Douse
title	Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_short	Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_full	Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_fullStr	Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_full_unstemmed	Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
title_sort	neuropathic morc2 mutations perturb ghkl atpase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7fb05d6f62c94a08a8f144e58ba79a09
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Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

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