A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID

Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms (PSP), before...

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Autores principales:	Alberto Utrero-Rico, María Ruiz-Ruigómez, Rocío Laguna-Goya, Estíbaliz Arrieta-Ortubay, Marta Chivite-Lacaba, Cecilia González-Cuadrado, Antonio Lalueza, Patricia Almendro-Vazquez, Antonio Serrano, José María Aguado, Carlos Lumbreras, Estela Paz-Artal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	long-COVID immunological alterations corticosteroids Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7fb1999631774cafb154ddaba91cf7fa
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spelling	oai:doaj.org-article:7fb1999631774cafb154ddaba91cf7fa2021-11-25T16:48:46ZA Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID10.3390/biomedicines91115402227-9059https://doaj.org/article/7fb1999631774cafb154ddaba91cf7fa2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1540https://doaj.org/toc/2227-9059Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms (PSP), before and after a 4-day prednisone course, and five post-COVID-19 patients without persistent symptoms (NSP). PSP showed a perturbed distribution of circulating mononuclear cell populations. Symptoms in PSP were accompanied by a pro-inflammatory phenotype characterized by increased conventional dendritic cells and augmented expression of antigen presentation, co-stimulation, migration, and activation markers in monocytes. The adaptive immunity compartment in PSP showed a Th1-predominance, decreased naïve and regulatory T cells, and augmentation of the PD-1 exhaustion marker. These immune alterations reverted after the corticosteroid treatment and were maintained during the 4-month follow-up, and their normalization correlated with clinical amelioration. The current work highlights an immunopathogenic basis together with a possible role for steroids in the treatment for long-COVID.Alberto Utrero-RicoMaría Ruiz-RuigómezRocío Laguna-GoyaEstíbaliz Arrieta-OrtubayMarta Chivite-LacabaCecilia González-CuadradoAntonio LaluezaPatricia Almendro-VazquezAntonio SerranoJosé María AguadoCarlos LumbrerasEstela Paz-ArtalMDPI AGarticlelong-COVIDimmunological alterationscorticosteroidsBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1540, p 1540 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	long-COVID immunological alterations corticosteroids Biology (General) QH301-705.5
spellingShingle	long-COVID immunological alterations corticosteroids Biology (General) QH301-705.5 Alberto Utrero-Rico María Ruiz-Ruigómez Rocío Laguna-Goya Estíbaliz Arrieta-Ortubay Marta Chivite-Lacaba Cecilia González-Cuadrado Antonio Lalueza Patricia Almendro-Vazquez Antonio Serrano José María Aguado Carlos Lumbreras Estela Paz-Artal A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
description	Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms (PSP), before and after a 4-day prednisone course, and five post-COVID-19 patients without persistent symptoms (NSP). PSP showed a perturbed distribution of circulating mononuclear cell populations. Symptoms in PSP were accompanied by a pro-inflammatory phenotype characterized by increased conventional dendritic cells and augmented expression of antigen presentation, co-stimulation, migration, and activation markers in monocytes. The adaptive immunity compartment in PSP showed a Th1-predominance, decreased naïve and regulatory T cells, and augmentation of the PD-1 exhaustion marker. These immune alterations reverted after the corticosteroid treatment and were maintained during the 4-month follow-up, and their normalization correlated with clinical amelioration. The current work highlights an immunopathogenic basis together with a possible role for steroids in the treatment for long-COVID.
format	article
author	Alberto Utrero-Rico María Ruiz-Ruigómez Rocío Laguna-Goya Estíbaliz Arrieta-Ortubay Marta Chivite-Lacaba Cecilia González-Cuadrado Antonio Lalueza Patricia Almendro-Vazquez Antonio Serrano José María Aguado Carlos Lumbreras Estela Paz-Artal
author_facet	Alberto Utrero-Rico María Ruiz-Ruigómez Rocío Laguna-Goya Estíbaliz Arrieta-Ortubay Marta Chivite-Lacaba Cecilia González-Cuadrado Antonio Lalueza Patricia Almendro-Vazquez Antonio Serrano José María Aguado Carlos Lumbreras Estela Paz-Artal
author_sort	Alberto Utrero-Rico
title	A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_short	A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_full	A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_fullStr	A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_full_unstemmed	A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
title_sort	short corticosteroid course reduces symptoms and immunological alterations underlying long-covid
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7fb1999631774cafb154ddaba91cf7fa
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A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID

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