Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

α-synuclein is a protein linked to the occurrence of Parkinson's disease. Here, the authors use time-resolved in-cell NMR spectroscopy to study the repair of methionine-oxidized α-synuclein by endogenous cellular enzymes.

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Autores principales: Andres Binolfi, Antonio Limatola, Silvia Verzini, Jonas Kosten, Francois-Xavier Theillet, Honor May Rose, Beata Bekei, Marchel Stuiver, Marleen van Rossum, Philipp Selenko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/7fb253fdcc4e4807873bdf93d8263baf
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spelling oai:doaj.org-article:7fb253fdcc4e4807873bdf93d8263baf2021-12-02T16:57:39ZIntracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites10.1038/ncomms102512041-1723https://doaj.org/article/7fb253fdcc4e4807873bdf93d8263baf2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10251https://doaj.org/toc/2041-1723α-synuclein is a protein linked to the occurrence of Parkinson's disease. Here, the authors use time-resolved in-cell NMR spectroscopy to study the repair of methionine-oxidized α-synuclein by endogenous cellular enzymes.Andres BinolfiAntonio LimatolaSilvia VerziniJonas KostenFrancois-Xavier TheilletHonor May RoseBeata BekeiMarchel StuiverMarleen van RossumPhilipp SelenkoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andres Binolfi
Antonio Limatola
Silvia Verzini
Jonas Kosten
Francois-Xavier Theillet
Honor May Rose
Beata Bekei
Marchel Stuiver
Marleen van Rossum
Philipp Selenko
Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
description α-synuclein is a protein linked to the occurrence of Parkinson's disease. Here, the authors use time-resolved in-cell NMR spectroscopy to study the repair of methionine-oxidized α-synuclein by endogenous cellular enzymes.
format article
author Andres Binolfi
Antonio Limatola
Silvia Verzini
Jonas Kosten
Francois-Xavier Theillet
Honor May Rose
Beata Bekei
Marchel Stuiver
Marleen van Rossum
Philipp Selenko
author_facet Andres Binolfi
Antonio Limatola
Silvia Verzini
Jonas Kosten
Francois-Xavier Theillet
Honor May Rose
Beata Bekei
Marchel Stuiver
Marleen van Rossum
Philipp Selenko
author_sort Andres Binolfi
title Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
title_short Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
title_full Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
title_fullStr Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
title_full_unstemmed Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
title_sort intracellular repair of oxidation-damaged α-synuclein fails to target c-terminal modification sites
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/7fb253fdcc4e4807873bdf93d8263baf
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