Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.

The purpose of our study was to evaluate the left ventricular (LV) and left atrial (LA) function in patients with gout. A total of 173 patients underwent a comprehensive Doppler-echocardiography examination. Participants were divided into four groups-Stage 0: control (n = 35), Stage I: asymptomatic...

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Autores principales:	Kuo-Li Pan, Jing-Chi Lin, Chun-Liang Lin, Mien-Cheng Chen, Shih-Tai Chang, Chang-Min Chung, Jen-Te Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7fb27fada2d24773812b887a39a2f8b9
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spelling	oai:doaj.org-article:7fb27fada2d24773812b887a39a2f8b92021-11-25T05:59:34ZImpact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.1932-620310.1371/journal.pone.0108357https://doaj.org/article/7fb27fada2d24773812b887a39a2f8b92014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0108357https://doaj.org/toc/1932-6203The purpose of our study was to evaluate the left ventricular (LV) and left atrial (LA) function in patients with gout. A total of 173 patients underwent a comprehensive Doppler-echocardiography examination. Participants were divided into four groups-Stage 0: control (n = 35), Stage I: asymptomatic hyperuricemia (n = 30), Stage II: gouty arthritis without tophi (n = 58), and Stage III: tophaceous gout (n = 50). Serum uric acid levels were not significantly different between stage I, II and III. Stage III patients demonstrated a higher ratio of the transmitral and myocardial peak early diastolic velocities (E/Em) (10.50 ± 3.18 vs. 8.58 ± 2.07; P = 0.008), and larger maximal LA volume index (LAVi) (29.60 ± 9.89 vs. 20.07 ± 4.76 ml/m(2); P<0.001) compared with controls. Stage III patients had decreased LV global longitudinal systolic strain (LVε) compared with controls (-20.2 ± 3.06 vs. -21.79 ± 2.27; P = 0.002). Stage III patients also had decreased peak atrial longitudinal strain rate during ventricular systole (ALSR(syst)), peak atrial longitudinal strain rate during ventricular early diastole (ALSR(early)), and peak atrial longitudinal strain rate during ventricular late diastole (ALSR(late)) compared with controls (1.73 ± 0.48 vs. 2.05 ± 0.55 1/s, -1.44 ± 0.53 vs. -2.07 ± 0.84 1/s, -2.07 ± 0.7 vs. -2.66 ± 0.91 1/s, respectively; all P<0.005). Multiple regression analysis revealed severity of gout had an independent negative impact on LA pump function (ALSR(late)). In conclusion, gout caused LV diastolic dysfunction, LV subclinical systolic dysfunction and LA reservoir, conduit, and booster pump dysfunction.Kuo-Li PanJing-Chi LinChun-Liang LinMien-Cheng ChenShih-Tai ChangChang-Min ChungJen-Te HsuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e108357 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuo-Li Pan Jing-Chi Lin Chun-Liang Lin Mien-Cheng Chen Shih-Tai Chang Chang-Min Chung Jen-Te Hsu Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.
description	The purpose of our study was to evaluate the left ventricular (LV) and left atrial (LA) function in patients with gout. A total of 173 patients underwent a comprehensive Doppler-echocardiography examination. Participants were divided into four groups-Stage 0: control (n = 35), Stage I: asymptomatic hyperuricemia (n = 30), Stage II: gouty arthritis without tophi (n = 58), and Stage III: tophaceous gout (n = 50). Serum uric acid levels were not significantly different between stage I, II and III. Stage III patients demonstrated a higher ratio of the transmitral and myocardial peak early diastolic velocities (E/Em) (10.50 ± 3.18 vs. 8.58 ± 2.07; P = 0.008), and larger maximal LA volume index (LAVi) (29.60 ± 9.89 vs. 20.07 ± 4.76 ml/m(2); P<0.001) compared with controls. Stage III patients had decreased LV global longitudinal systolic strain (LVε) compared with controls (-20.2 ± 3.06 vs. -21.79 ± 2.27; P = 0.002). Stage III patients also had decreased peak atrial longitudinal strain rate during ventricular systole (ALSR(syst)), peak atrial longitudinal strain rate during ventricular early diastole (ALSR(early)), and peak atrial longitudinal strain rate during ventricular late diastole (ALSR(late)) compared with controls (1.73 ± 0.48 vs. 2.05 ± 0.55 1/s, -1.44 ± 0.53 vs. -2.07 ± 0.84 1/s, -2.07 ± 0.7 vs. -2.66 ± 0.91 1/s, respectively; all P<0.005). Multiple regression analysis revealed severity of gout had an independent negative impact on LA pump function (ALSR(late)). In conclusion, gout caused LV diastolic dysfunction, LV subclinical systolic dysfunction and LA reservoir, conduit, and booster pump dysfunction.
format	article
author	Kuo-Li Pan Jing-Chi Lin Chun-Liang Lin Mien-Cheng Chen Shih-Tai Chang Chang-Min Chung Jen-Te Hsu
author_facet	Kuo-Li Pan Jing-Chi Lin Chun-Liang Lin Mien-Cheng Chen Shih-Tai Chang Chang-Min Chung Jen-Te Hsu
author_sort	Kuo-Li Pan
title	Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.
title_short	Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.
title_full	Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.
title_fullStr	Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.
title_full_unstemmed	Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.
title_sort	impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7fb27fada2d24773812b887a39a2f8b9
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Impact of gout on left atrial function: a prospective speckle-tracking echocardiographic study.

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