Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.
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Nature Portfolio
2020
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oai:doaj.org-article:7fb30f4555cf4ea288f251cabb681d852021-12-02T16:43:41ZTargeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia10.1038/s41467-020-17594-72041-1723https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d852020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17594-7https://doaj.org/toc/2041-1723Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.Myriam L. R. HaltalliCristina Lo CelsoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-3 (2020) |
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Science Q Myriam L. R. Haltalli Cristina Lo Celso Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia |
description |
Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes. |
format |
article |
author |
Myriam L. R. Haltalli Cristina Lo Celso |
author_facet |
Myriam L. R. Haltalli Cristina Lo Celso |
author_sort |
Myriam L. R. Haltalli |
title |
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia |
title_short |
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia |
title_full |
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia |
title_fullStr |
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia |
title_full_unstemmed |
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia |
title_sort |
targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d85 |
work_keys_str_mv |
AT myriamlrhaltalli targetingadhesiontothevascularnichetoimprovetherapyforacutemyeloidleukemia AT cristinalocelso targetingadhesiontothevascularnichetoimprovetherapyforacutemyeloidleukemia |
_version_ |
1718383524844666880 |