Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia

Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.

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Autores principales: Myriam L. R. Haltalli, Cristina Lo Celso
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d85
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spelling oai:doaj.org-article:7fb30f4555cf4ea288f251cabb681d852021-12-02T16:43:41ZTargeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia10.1038/s41467-020-17594-72041-1723https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d852020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17594-7https://doaj.org/toc/2041-1723Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.Myriam L. R. HaltalliCristina Lo CelsoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Myriam L. R. Haltalli
Cristina Lo Celso
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
description Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.
format article
author Myriam L. R. Haltalli
Cristina Lo Celso
author_facet Myriam L. R. Haltalli
Cristina Lo Celso
author_sort Myriam L. R. Haltalli
title Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_short Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_full Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_fullStr Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_full_unstemmed Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_sort targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d85
work_keys_str_mv AT myriamlrhaltalli targetingadhesiontothevascularnichetoimprovetherapyforacutemyeloidleukemia
AT cristinalocelso targetingadhesiontothevascularnichetoimprovetherapyforacutemyeloidleukemia
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