Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia

Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.

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Main Authors:	Myriam L. R. Haltalli, Cristina Lo Celso
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d85
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spelling	oai:doaj.org-article:7fb30f4555cf4ea288f251cabb681d852021-12-02T16:43:41ZTargeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia10.1038/s41467-020-17594-72041-1723https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d852020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17594-7https://doaj.org/toc/2041-1723Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.Myriam L. R. HaltalliCristina Lo CelsoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myriam L. R. Haltalli Cristina Lo Celso Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
description	Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.
format	article
author	Myriam L. R. Haltalli Cristina Lo Celso
author_facet	Myriam L. R. Haltalli Cristina Lo Celso
author_sort	Myriam L. R. Haltalli
title	Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_short	Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_full	Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_fullStr	Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_full_unstemmed	Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_sort	targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7fb30f4555cf4ea288f251cabb681d85
work_keys_str_mv	AT myriamlrhaltalli targetingadhesiontothevascularnichetoimprovetherapyforacutemyeloidleukemia AT cristinalocelso targetingadhesiontothevascularnichetoimprovetherapyforacutemyeloidleukemia
_version_	1718383524844666880

Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia

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