Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer

Raminder Singh,1,2 Gokhan Dumlupinar,3,4 Stefan Andersson-Engels,3,4 Silvia Melgar1 1APC Microbiome Ireland, University College Cork, Cork, Ireland; 2School of Medicine, University College Cork, Cork, Ireland; 3Irish Photonics Integration Centre, Tyndall National Institute, Cork, Ireland; 4Departme...

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Autores principales:	Singh R, Dumlupinar G, Andersson-Engels S, Melgar S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	near-infrared imaging bacteria photodynamic therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7fb320729dcd4460ab5a3b0b44eebc0f
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spelling	oai:doaj.org-article:7fb320729dcd4460ab5a3b0b44eebc0f2021-12-02T07:39:30ZEmerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer1178-2013https://doaj.org/article/7fb320729dcd4460ab5a3b0b44eebc0f2019-02-01T00:00:00Zhttps://www.dovepress.com/emerging-applications-of-upconverting-nanoparticles-in-intestinal-infe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Raminder Singh,1,2 Gokhan Dumlupinar,3,4 Stefan Andersson-Engels,3,4 Silvia Melgar1 1APC Microbiome Ireland, University College Cork, Cork, Ireland; 2School of Medicine, University College Cork, Cork, Ireland; 3Irish Photonics Integration Centre, Tyndall National Institute, Cork, Ireland; 4Department of Physics, University College Cork, Cork, Ireland Abstract: Colorectal cancer is the abnormal growth of cells in colon or rectum. Recent findings have acknowledged the role of bacterial infection and chronic inflammation in colorectal cancer initiation and progression. In order to detect and treat precancerous lesions, new tools are required, which may help to prevent or identify colorectal cancer at an early stage. To date, several different screening tests are available, including endoscopy, stool-based blood tests, and radiology-based tests. However, these analyses either lack sensitivity or are of an invasive nature. The use of fluorescently labeled probes can increase the detection sensitivity. However, autofluorescence, photobleaching, and photodamage are commonly encountered problems with fluorescence imaging. Upconverting nanoparticles (UCNPs) are recently developed lanthanide-doped nanocrystals that can be used as light-triggered luminescent probes and in drug delivery systems. In this review, we comprehensively summarize the recent developments and address future prospects of UCNP-based applications for diagnostics and therapeutic approaches associated with intestinal infection and colorectal cancer. Keywords: near infrared, imaging, bacteria, photodynamic therapy, anti-Stokes emission, inflammationSingh RDumlupinar GAndersson-Engels SMelgar SDove Medical Pressarticlenear-infraredimagingbacteriaphotodynamic therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1027-1038 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	near-infrared imaging bacteria photodynamic therapy Medicine (General) R5-920
spellingShingle	near-infrared imaging bacteria photodynamic therapy Medicine (General) R5-920 Singh R Dumlupinar G Andersson-Engels S Melgar S Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
description	Raminder Singh,1,2 Gokhan Dumlupinar,3,4 Stefan Andersson-Engels,3,4 Silvia Melgar1 1APC Microbiome Ireland, University College Cork, Cork, Ireland; 2School of Medicine, University College Cork, Cork, Ireland; 3Irish Photonics Integration Centre, Tyndall National Institute, Cork, Ireland; 4Department of Physics, University College Cork, Cork, Ireland Abstract: Colorectal cancer is the abnormal growth of cells in colon or rectum. Recent findings have acknowledged the role of bacterial infection and chronic inflammation in colorectal cancer initiation and progression. In order to detect and treat precancerous lesions, new tools are required, which may help to prevent or identify colorectal cancer at an early stage. To date, several different screening tests are available, including endoscopy, stool-based blood tests, and radiology-based tests. However, these analyses either lack sensitivity or are of an invasive nature. The use of fluorescently labeled probes can increase the detection sensitivity. However, autofluorescence, photobleaching, and photodamage are commonly encountered problems with fluorescence imaging. Upconverting nanoparticles (UCNPs) are recently developed lanthanide-doped nanocrystals that can be used as light-triggered luminescent probes and in drug delivery systems. In this review, we comprehensively summarize the recent developments and address future prospects of UCNP-based applications for diagnostics and therapeutic approaches associated with intestinal infection and colorectal cancer. Keywords: near infrared, imaging, bacteria, photodynamic therapy, anti-Stokes emission, inflammation
format	article
author	Singh R Dumlupinar G Andersson-Engels S Melgar S
author_facet	Singh R Dumlupinar G Andersson-Engels S Melgar S
author_sort	Singh R
title	Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
title_short	Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
title_full	Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
title_fullStr	Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
title_full_unstemmed	Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
title_sort	emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7fb320729dcd4460ab5a3b0b44eebc0f
work_keys_str_mv	AT singhr emergingapplicationsofupconvertingnanoparticlesinintestinalinfectionandcolorectalcancer AT dumlupinarg emergingapplicationsofupconvertingnanoparticlesinintestinalinfectionandcolorectalcancer AT anderssonengelss emergingapplicationsofupconvertingnanoparticlesinintestinalinfectionandcolorectalcancer AT melgars emergingapplicationsofupconvertingnanoparticlesinintestinalinfectionandcolorectalcancer
_version_	1718399292237938688

Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer

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