Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.

<h4>Aim</h4>The aim of this study was to determine the seroprevalence of Hepatitis E virus (HEV) among blood donors in southwest Switzerland.<h4>Background</h4>HEV is recognized as a food-borne disease in industrialized countries, transmitted mainly through pork meat. Cases o...

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Autores principales:	Annatina Kaufmann, Alain Kenfak-Foguena, Cyril André, Giorgia Canellini, Philippe Bürgisser, Darius Moradpour, Katharine E A Darling, Matthias Cavassini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7fb323c0de2845649969b544f771cfd8
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spelling	oai:doaj.org-article:7fb323c0de2845649969b544f771cfd82021-11-18T06:51:45ZHepatitis E virus seroprevalence among blood donors in southwest Switzerland.1932-620310.1371/journal.pone.0021150https://doaj.org/article/7fb323c0de2845649969b544f771cfd82011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21701586/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aim</h4>The aim of this study was to determine the seroprevalence of Hepatitis E virus (HEV) among blood donors in southwest Switzerland.<h4>Background</h4>HEV is recognized as a food-borne disease in industrialized countries, transmitted mainly through pork meat. Cases of transmission through blood transfusion have also been reported. Recent studies have revealed seroprevalence rates of 13.5%, 16.6% and 20.6% among blood donors in England, France and Denmark, respectively.<h4>Methods</h4>We analyzed 550 consecutive blood donor samples collected in the region of Lausanne, canton of Vaud, Switzerland, for the presence of anti-HEV IgG, using the MP Diagnostics HEV ELISA kit. For each donor, we documented age, sex and alanine aminotransferase (ALT) value.<h4>Results</h4>The study panel was composed of 332 men (60.4%) and 218 women (39.6%). Overall, anti-HEV IgG was found in 27 of 550 samples (4.9%). The seroprevalence was 5.4% (18/332) in men and 4.1% (9/218) in women. The presence of anti-HEV IgG was not correlated with age, gender or ALT values. However, we observed a peak in seroprevalence of 5.3% in individuals aged 51 to 70 years old.<h4>Conclusions</h4>Compared with other European countries, HEV seroprevalence among blood donors in southwest Switzerland is low. The low seroprevalence may be explained by the sensitivity of commercial tests used and/or the strict regulation of animal and meat imports. Data regarding HEV prevalence in Swiss livestock are lacking and merit exploration.Annatina KaufmannAlain Kenfak-FoguenaCyril AndréGiorgia CanelliniPhilippe BürgisserDarius MoradpourKatharine E A DarlingMatthias CavassiniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21150 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annatina Kaufmann Alain Kenfak-Foguena Cyril André Giorgia Canellini Philippe Bürgisser Darius Moradpour Katharine E A Darling Matthias Cavassini Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.
description	<h4>Aim</h4>The aim of this study was to determine the seroprevalence of Hepatitis E virus (HEV) among blood donors in southwest Switzerland.<h4>Background</h4>HEV is recognized as a food-borne disease in industrialized countries, transmitted mainly through pork meat. Cases of transmission through blood transfusion have also been reported. Recent studies have revealed seroprevalence rates of 13.5%, 16.6% and 20.6% among blood donors in England, France and Denmark, respectively.<h4>Methods</h4>We analyzed 550 consecutive blood donor samples collected in the region of Lausanne, canton of Vaud, Switzerland, for the presence of anti-HEV IgG, using the MP Diagnostics HEV ELISA kit. For each donor, we documented age, sex and alanine aminotransferase (ALT) value.<h4>Results</h4>The study panel was composed of 332 men (60.4%) and 218 women (39.6%). Overall, anti-HEV IgG was found in 27 of 550 samples (4.9%). The seroprevalence was 5.4% (18/332) in men and 4.1% (9/218) in women. The presence of anti-HEV IgG was not correlated with age, gender or ALT values. However, we observed a peak in seroprevalence of 5.3% in individuals aged 51 to 70 years old.<h4>Conclusions</h4>Compared with other European countries, HEV seroprevalence among blood donors in southwest Switzerland is low. The low seroprevalence may be explained by the sensitivity of commercial tests used and/or the strict regulation of animal and meat imports. Data regarding HEV prevalence in Swiss livestock are lacking and merit exploration.
format	article
author	Annatina Kaufmann Alain Kenfak-Foguena Cyril André Giorgia Canellini Philippe Bürgisser Darius Moradpour Katharine E A Darling Matthias Cavassini
author_facet	Annatina Kaufmann Alain Kenfak-Foguena Cyril André Giorgia Canellini Philippe Bürgisser Darius Moradpour Katharine E A Darling Matthias Cavassini
author_sort	Annatina Kaufmann
title	Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.
title_short	Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.
title_full	Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.
title_fullStr	Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.
title_full_unstemmed	Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.
title_sort	hepatitis e virus seroprevalence among blood donors in southwest switzerland.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/7fb323c0de2845649969b544f771cfd8
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Hepatitis E virus seroprevalence among blood donors in southwest Switzerland.

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