GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2

Abstract. The article includes results of studying frequency distributions of polymorphic genotypes forsome genes regulating angiogenesis, i.e., MMP and VEGF, and their combinations with genotypes of some cytokines showing pro-angiogenic activity in patients with diabetes mellitus type 2 (DM2) and h...

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Autores principales:	V. I. Konenkov, A. V. Shevchenko, V. F. Prokof’ev, V. V. Klimontov, M. A. Korolev, O. N. Fazulina, S. A. Lapsina, E. A. Koroleva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	matrix metalloproteinases vegf cytokines gene polymorphism diabetes mellitus type 2 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7fb3d47bb28d46a092270c2b6665ebed
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spelling	oai:doaj.org-article:7fb3d47bb28d46a092270c2b6665ebed2021-11-18T08:03:42ZGENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 21563-06252313-741X10.15789/1563-0625-2012-6-489-500https://doaj.org/article/7fb3d47bb28d46a092270c2b6665ebed2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/547https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The article includes results of studying frequency distributions of polymorphic genotypes forsome genes regulating angiogenesis, i.e., MMP and VEGF, and their combinations with genotypes of some cytokines showing pro-angiogenic activity in patients with diabetes mellitus type 2 (DM2) and healthy controls. Angiogenesis-inducing MMP2-MMP9-VEGF genotype constellations have been shown to be more common in DM patients, thus presumably causing an imbalance between activation and suppression signals, being connected with C alleles of VEGF and MMP2, as well as with harboring of MMP9 C allele. Certain genotypes of IL-1B, IL-4, IL-10, IL-6, and TNFA, along with MMP and VEGF variants are more common within combined genetic patterns in DM patients. It is suggested that allelic combination studies of angiogenesis- and inflammation-regulating genes are necessary for understanding the DM2 pathogenesis, taking into account genetic control mechanisms influencing basic production levels of these regulatory factors.V. I. KonenkovA. V. ShevchenkoV. F. Prokof’evV. V. KlimontovM. A. KorolevO. N. FazulinaS. A. LapsinaE. A. KorolevaSPb RAACIarticlematrix metalloproteinasesvegfcytokinesgene polymorphismdiabetes mellitus type 2Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 489-500 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	matrix metalloproteinases vegf cytokines gene polymorphism diabetes mellitus type 2 Immunologic diseases. Allergy RC581-607
spellingShingle	matrix metalloproteinases vegf cytokines gene polymorphism diabetes mellitus type 2 Immunologic diseases. Allergy RC581-607 V. I. Konenkov A. V. Shevchenko V. F. Prokof’ev V. V. Klimontov M. A. Korolev O. N. Fazulina S. A. Lapsina E. A. Koroleva GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2
description	Abstract. The article includes results of studying frequency distributions of polymorphic genotypes forsome genes regulating angiogenesis, i.e., MMP and VEGF, and their combinations with genotypes of some cytokines showing pro-angiogenic activity in patients with diabetes mellitus type 2 (DM2) and healthy controls. Angiogenesis-inducing MMP2-MMP9-VEGF genotype constellations have been shown to be more common in DM patients, thus presumably causing an imbalance between activation and suppression signals, being connected with C alleles of VEGF and MMP2, as well as with harboring of MMP9 C allele. Certain genotypes of IL-1B, IL-4, IL-10, IL-6, and TNFA, along with MMP and VEGF variants are more common within combined genetic patterns in DM patients. It is suggested that allelic combination studies of angiogenesis- and inflammation-regulating genes are necessary for understanding the DM2 pathogenesis, taking into account genetic control mechanisms influencing basic production levels of these regulatory factors.
format	article
author	V. I. Konenkov A. V. Shevchenko V. F. Prokof’ev V. V. Klimontov M. A. Korolev O. N. Fazulina S. A. Lapsina E. A. Koroleva
author_facet	V. I. Konenkov A. V. Shevchenko V. F. Prokof’ev V. V. Klimontov M. A. Korolev O. N. Fazulina S. A. Lapsina E. A. Koroleva
author_sort	V. I. Konenkov
title	GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2
title_short	GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2
title_full	GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2
title_fullStr	GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2
title_full_unstemmed	GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2
title_sort	genetic factors inducing disturbed regulation of angiogenesis in diabetes mellitus type 2
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7fb3d47bb28d46a092270c2b6665ebed
work_keys_str_mv	AT vikonenkov geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2 AT avshevchenko geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2 AT vfprokofev geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2 AT vvklimontov geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2 AT makorolev geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2 AT onfazulina geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2 AT salapsina geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2 AT eakoroleva geneticfactorsinducingdisturbedregulationofangiogenesisindiabetesmellitustype2
_version_	1718422488002592768

GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2

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