Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

Abstract All medically important unicellular protozoans cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Therefore, purine derivatives have been considered as a promising source of anti-parasitic compounds since they can ac...

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Autores principales: Eva Doleželová, Tomáš Klejch, Petr Špaček, Martina Slapničková, Luke Guddat, Dana Hocková, Alena Zíková
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7fb8cd7b12b54150b152a5cdc8ad9e6f
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