Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.

<h4>Background</h4>To study in a large-scale cohort with prospective data the associations between psychosocial stress during pregnancy and placenta weight at birth. Animal data suggest that the placenta is involved in stress-related fetal programming.<h4>Methodology/principal find...

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Autores principales:	Marion Tegethoff, Naomi Greene, Jørn Olsen, Andrea H Meyer, Gunther Meinlschmidt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7fb90d82074e4a3e9ab781fd12adc3dc
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spelling	oai:doaj.org-article:7fb90d82074e4a3e9ab781fd12adc3dc2021-11-18T07:00:49ZMaternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.1932-620310.1371/journal.pone.0014478https://doaj.org/article/7fb90d82074e4a3e9ab781fd12adc3dc2010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21217829/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To study in a large-scale cohort with prospective data the associations between psychosocial stress during pregnancy and placenta weight at birth. Animal data suggest that the placenta is involved in stress-related fetal programming.<h4>Methodology/principal findings</h4>We defined a priori two types of psychosocial stress during pregnancy, life stress (perceived burdens in major areas of life) and emotional symptoms (e.g. anxiety). We estimated the associations of maternal stress during pregnancy with placenta weight at birth, controlled for length of gestation, by predicting gestational age- and sex-specific z-scores of placenta weight through multiple regression analysis, adjusted for potential confounders (N = 78,017 singleton pregnancies). Life stress (per increase in stress score by 1, range: 0-18) during pregnancy was associated with increased placenta weight at birth (z-score, reported in 10(-3); B, 14.33; CI, 10.12-18.54). In contrast, emotional symptoms during pregnancy were not associated with placenta weight at birth.<h4>Conclusions/significance</h4>Maternal life stress but not emotional symptoms during pregnancy was associated with increased placenta weight at birth; yet, the association-estimate was rather small. Our results may contribute to a better understanding of the role of the placenta in the regulation of intrauterine processes in response to maternal stress.Marion TegethoffNaomi GreeneJørn OlsenAndrea H MeyerGunther MeinlschmidtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e14478 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marion Tegethoff Naomi Greene Jørn Olsen Andrea H Meyer Gunther Meinlschmidt Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.
description	<h4>Background</h4>To study in a large-scale cohort with prospective data the associations between psychosocial stress during pregnancy and placenta weight at birth. Animal data suggest that the placenta is involved in stress-related fetal programming.<h4>Methodology/principal findings</h4>We defined a priori two types of psychosocial stress during pregnancy, life stress (perceived burdens in major areas of life) and emotional symptoms (e.g. anxiety). We estimated the associations of maternal stress during pregnancy with placenta weight at birth, controlled for length of gestation, by predicting gestational age- and sex-specific z-scores of placenta weight through multiple regression analysis, adjusted for potential confounders (N = 78,017 singleton pregnancies). Life stress (per increase in stress score by 1, range: 0-18) during pregnancy was associated with increased placenta weight at birth (z-score, reported in 10(-3); B, 14.33; CI, 10.12-18.54). In contrast, emotional symptoms during pregnancy were not associated with placenta weight at birth.<h4>Conclusions/significance</h4>Maternal life stress but not emotional symptoms during pregnancy was associated with increased placenta weight at birth; yet, the association-estimate was rather small. Our results may contribute to a better understanding of the role of the placenta in the regulation of intrauterine processes in response to maternal stress.
format	article
author	Marion Tegethoff Naomi Greene Jørn Olsen Andrea H Meyer Gunther Meinlschmidt
author_facet	Marion Tegethoff Naomi Greene Jørn Olsen Andrea H Meyer Gunther Meinlschmidt
author_sort	Marion Tegethoff
title	Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.
title_short	Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.
title_full	Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.
title_fullStr	Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.
title_full_unstemmed	Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.
title_sort	maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/7fb90d82074e4a3e9ab781fd12adc3dc
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Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study.

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