CpG Frequency in the 5′ Third of the <italic toggle="yes">env</italic> Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

ABSTRACT CpG dinucleotide suppression has been reported to allow HIV-1 to evade inhibition by the zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked differences in CpG frequencies across their genome, ranging from 0.44% in simian immunodeficiency virus SIVwrc...

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Bibliographic Details
Main Authors:	Dorota Kmiec, Rayhane Nchioua, Scott Sherrill-Mix, Christina M. Stürzel, Elena Heusinger, Elisabeth Braun, Marcos V. P. Gondim, Dominik Hotter, Konstantin M. J. Sparrer, Beatrice H. Hahn, Daniel Sauter, Frank Kirchhoff
Format:	article
Language:	EN
Published:	American Society for Microbiology 2020
Subjects:	CpG dinucleotides envelope gene human immunodeficiency virus restriction factors zinc-finger antiviral protein Microbiology QR1-502
Online Access:	https://doaj.org/article/7fb955a32f4b4d7485d84d077ece1b08
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CpG Frequency in the 5′ Third of the <italic toggle="yes">env</italic> Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

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