The SUN1-SPDYA interaction plays an essential role in meiosis prophase I

Telomeres attach to the nuclear envelope to facilitate homolog pairing during meiosis prophase I. Here, the authors show that SUN1 and SPDYA interact, and demonstrate that this interaction is important for telomere structure and function, and essential to mice gametogenesis.

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Autores principales: Yanyan Chen, Yan Wang, Juan Chen, Wu Zuo, Yong Fan, Sijia Huang, Yongmei Liu, Guangming Chen, Qing Li, Jinsong Li, Jian Wu, Qian Bian, Chenhui Huang, Ming Lei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7fbbc5f66def47a687968563e913e76a
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Sumario:Telomeres attach to the nuclear envelope to facilitate homolog pairing during meiosis prophase I. Here, the authors show that SUN1 and SPDYA interact, and demonstrate that this interaction is important for telomere structure and function, and essential to mice gametogenesis.