Quantitative Analysis of Cell Aggregation Dynamics Identifies HDAC Inhibitors as Potential Regulators of Cancer Cell Clustering

Quantitative Analysis of Cell Aggregation Dynamics Identifies HDAC Inhibitors as Potential Regulators of Cancer Cell Clustering

Characterization of the molecular mechanisms involved in tumor cell clustering could open the way to new therapeutic strategies. Towards this aim, we used an in vitro quantitative procedure to monitor the anchorage-independent cell aggregation kinetics in a panel of 25 cancer cell lines. The analysi...

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Bibliographic Details
Main Authors: Fabien Gava, Julie Pignolet, Sébastien Déjean, Odile Mondésert, Renaud Morin, Joseph Agossa, Bernard Ducommun, Valérie Lobjois
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
cancer cell clustering
anchorage-independent aggregation
transcriptional expression
Connectivity Map
HDAC inhibitors
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/7fbc2370ea7e4d499deca56e9773a8ed
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https://doaj.org/article/7fbc2370ea7e4d499deca56e9773a8ed

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