Tamoxifen therapy in a murine model of myotubular myopathy

Myotubular myopathy is a severe muscle disease for which no effective treatment exists. Here, the authors show that tamoxifen ameliorates pathology and extends survival in a mouse model of the disease, and that the effect is mediated via estrogen receptor signaling and involves modulation of DNM2 ex...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nika Maani, Nesrin Sabha, Kamran Rezai, Arun Ramani, Linda Groom, Nadine Eltayeb, Faranak Mavandadnejad, Andrea Pang, Giulia Russo, Michael Brudno, Volker Haucke, Robert T. Dirksen, James J. Dowling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7fbfa0258973415ea77898bbaf016988
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7fbfa0258973415ea77898bbaf016988
record_format	dspace
spelling	oai:doaj.org-article:7fbfa0258973415ea77898bbaf0169882021-12-02T17:31:27ZTamoxifen therapy in a murine model of myotubular myopathy10.1038/s41467-018-07057-52041-1723https://doaj.org/article/7fbfa0258973415ea77898bbaf0169882018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07057-5https://doaj.org/toc/2041-1723Myotubular myopathy is a severe muscle disease for which no effective treatment exists. Here, the authors show that tamoxifen ameliorates pathology and extends survival in a mouse model of the disease, and that the effect is mediated via estrogen receptor signaling and involves modulation of DNM2 expression.Nika MaaniNesrin SabhaKamran RezaiArun RamaniLinda GroomNadine EltayebFaranak MavandadnejadAndrea PangGiulia RussoMichael BrudnoVolker HauckeRobert T. DirksenJames J. DowlingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nika Maani Nesrin Sabha Kamran Rezai Arun Ramani Linda Groom Nadine Eltayeb Faranak Mavandadnejad Andrea Pang Giulia Russo Michael Brudno Volker Haucke Robert T. Dirksen James J. Dowling Tamoxifen therapy in a murine model of myotubular myopathy
description	Myotubular myopathy is a severe muscle disease for which no effective treatment exists. Here, the authors show that tamoxifen ameliorates pathology and extends survival in a mouse model of the disease, and that the effect is mediated via estrogen receptor signaling and involves modulation of DNM2 expression.
format	article
author	Nika Maani Nesrin Sabha Kamran Rezai Arun Ramani Linda Groom Nadine Eltayeb Faranak Mavandadnejad Andrea Pang Giulia Russo Michael Brudno Volker Haucke Robert T. Dirksen James J. Dowling
author_facet	Nika Maani Nesrin Sabha Kamran Rezai Arun Ramani Linda Groom Nadine Eltayeb Faranak Mavandadnejad Andrea Pang Giulia Russo Michael Brudno Volker Haucke Robert T. Dirksen James J. Dowling
author_sort	Nika Maani
title	Tamoxifen therapy in a murine model of myotubular myopathy
title_short	Tamoxifen therapy in a murine model of myotubular myopathy
title_full	Tamoxifen therapy in a murine model of myotubular myopathy
title_fullStr	Tamoxifen therapy in a murine model of myotubular myopathy
title_full_unstemmed	Tamoxifen therapy in a murine model of myotubular myopathy
title_sort	tamoxifen therapy in a murine model of myotubular myopathy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7fbfa0258973415ea77898bbaf016988
work_keys_str_mv	AT nikamaani tamoxifentherapyinamurinemodelofmyotubularmyopathy AT nesrinsabha tamoxifentherapyinamurinemodelofmyotubularmyopathy AT kamranrezai tamoxifentherapyinamurinemodelofmyotubularmyopathy AT arunramani tamoxifentherapyinamurinemodelofmyotubularmyopathy AT lindagroom tamoxifentherapyinamurinemodelofmyotubularmyopathy AT nadineeltayeb tamoxifentherapyinamurinemodelofmyotubularmyopathy AT faranakmavandadnejad tamoxifentherapyinamurinemodelofmyotubularmyopathy AT andreapang tamoxifentherapyinamurinemodelofmyotubularmyopathy AT giuliarusso tamoxifentherapyinamurinemodelofmyotubularmyopathy AT michaelbrudno tamoxifentherapyinamurinemodelofmyotubularmyopathy AT volkerhaucke tamoxifentherapyinamurinemodelofmyotubularmyopathy AT roberttdirksen tamoxifentherapyinamurinemodelofmyotubularmyopathy AT jamesjdowling tamoxifentherapyinamurinemodelofmyotubularmyopathy
_version_	1718380623483109376

Tamoxifen therapy in a murine model of myotubular myopathy

Ejemplares similares