Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review

Rossella De Angelis, Jacopo Di Battista, Gianluca Smerilli, Edoardo Cipolletta, Marco Di Carlo, Fausto Salaffi Rheumatology Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Jesi, Ancona, ItalyCorrespondence: Rossella De AngelisRheumatology Clinic, “Carl...

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Autores principales:	De Angelis R, Di Battista J, Smerilli G, Cipolletta E, Di Carlo M, Salaffi F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	systemic sclerosis silicone breast implant anti-rna polymerase iii antibodies cancer Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/7fc476bab05b4e38a024344f1c33111a
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spelling	oai:doaj.org-article:7fc476bab05b4e38a024344f1c33111a2021-12-02T12:34:25ZAssociation of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review1179-156Xhttps://doaj.org/article/7fc476bab05b4e38a024344f1c33111a2020-09-01T00:00:00Zhttps://www.dovepress.com/association-of-silicone-breast-implants-breast-cancer-and-anti-rna-pol-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XRossella De Angelis, Jacopo Di Battista, Gianluca Smerilli, Edoardo Cipolletta, Marco Di Carlo, Fausto Salaffi Rheumatology Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Jesi, Ancona, ItalyCorrespondence: Rossella De AngelisRheumatology Clinic, “Carlo Urbani” Hospital, Jesi, Ancona 60035, ItalyEmail r.deangelis@staff.univpm.itAbstract: Some case reports and small case series of patients with silicone breast implant (SBI) have reported the development of systemic sclerosis (SSc) many years later, despite conflicting evidence of this association in the literature. Recently, patients with SSc and anti-RNA polymerase III antibodies positivity have been associated with previous silicone implants and/or breast cancer, showing clinical features that differ from the classic SSc, such as rapid and diffuse cutaneous involvement and scleroderma renal crisis (SRC). The specific autoimmune reaction is not yet fully understood, although knowledge in this regard is increasing. We describe a case that can support these previous observations, strengthening this association which must be taken into account. Clinicians should be aware of this new clinical entity, given the widespread use of silicone implants.Keywords: systemic sclerosis, silicone breast implant, anti-RNA polymerase III antibodies, cancerDe Angelis RDi Battista JSmerilli GCipolletta EDi Carlo MSalaffi FDove Medical Pressarticlesystemic sclerosissilicone breast implantanti-rna polymerase iii antibodiescancerDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 207-213 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic sclerosis silicone breast implant anti-rna polymerase iii antibodies cancer Diseases of the musculoskeletal system RC925-935
spellingShingle	systemic sclerosis silicone breast implant anti-rna polymerase iii antibodies cancer Diseases of the musculoskeletal system RC925-935 De Angelis R Di Battista J Smerilli G Cipolletta E Di Carlo M Salaffi F Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review
description	Rossella De Angelis, Jacopo Di Battista, Gianluca Smerilli, Edoardo Cipolletta, Marco Di Carlo, Fausto Salaffi Rheumatology Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Jesi, Ancona, ItalyCorrespondence: Rossella De AngelisRheumatology Clinic, “Carlo Urbani” Hospital, Jesi, Ancona 60035, ItalyEmail r.deangelis@staff.univpm.itAbstract: Some case reports and small case series of patients with silicone breast implant (SBI) have reported the development of systemic sclerosis (SSc) many years later, despite conflicting evidence of this association in the literature. Recently, patients with SSc and anti-RNA polymerase III antibodies positivity have been associated with previous silicone implants and/or breast cancer, showing clinical features that differ from the classic SSc, such as rapid and diffuse cutaneous involvement and scleroderma renal crisis (SRC). The specific autoimmune reaction is not yet fully understood, although knowledge in this regard is increasing. We describe a case that can support these previous observations, strengthening this association which must be taken into account. Clinicians should be aware of this new clinical entity, given the widespread use of silicone implants.Keywords: systemic sclerosis, silicone breast implant, anti-RNA polymerase III antibodies, cancer
format	article
author	De Angelis R Di Battista J Smerilli G Cipolletta E Di Carlo M Salaffi F
author_facet	De Angelis R Di Battista J Smerilli G Cipolletta E Di Carlo M Salaffi F
author_sort	De Angelis R
title	Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review
title_short	Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review
title_full	Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review
title_fullStr	Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review
title_full_unstemmed	Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review
title_sort	association of silicone breast implants, breast cancer and anti-rna polymerase iii autoantibodies in systemic sclerosis: case-based review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7fc476bab05b4e38a024344f1c33111a
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Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review

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